Mentoring and Research in Mouse Pathobiology

小鼠病理学的指导和研究

• 批准号: 6821179
• 负责人: CRAIG L FRANKLIN
• 金额: $ 9.76万
• 依托单位: UNIVERSITY OF MISSOURI-COLUMBIA
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-07-20 至 2009-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6821179
• 关键词: Helicobacter; antigen presenting cell; biological signal transduction; disease /disorder model; enteric bacteria; estrogen receptors; estrogens; gastrointestinal infection; gender difference; helper T lymphocyte; immunosuppression; inflammation; laboratory mouse; pathologic process; testosterone

DESCRIPTION (provided by applicant): With the explosion of genetically engineered mouse models, there are enormous opportunities for mouse pathobiologists in biomedical research. The Principal Investigator's career objectives are to become a more independent and successful mouse pathobiology researcher and to use existing skills as well as those developed through this proposal to mentor the next generation of mouse pathobiologists. His growth as a scientist has been hindered by time constraints associated with service, administrative and teaching responsibilities. This award will provide release from some of these responsibilities and redistribution of time in others so that he will have more focused and intensive research time. The candidate is very well qualified for this award by virtue of his extensive background in training and pathology, his experience in both independent and collaborative research and his environment which facilitates and promotes mouse pathobiology research and training. This environment includes a Comparative Medicine Training Program, a world-renowned Research Animal Diagnostic Laboratory, a Comparative Medicine Research Center and one of four Mutant Mouse Regional Resource Centers. Long-term research goals include unraveling the mechanisms of chronic intestinal inflammatory disease so that ultimately novel prevention and treatment strategies can be developed. The objectives of this proposal focus on differences seen between males and females in inflammatory diseases of the intestinal mucosa. The following specific aims will be employed in pursuit of these objectives: 1) determine what cell types characterize mucosal inflammation caused by H. hepaticus in the A/J mouse 2) assess the role of the gonadal steroid hormones, estrogen and testosterone, in pathogenesis of bacterial initiated mucosal inflammation and 3) assess the role of estrogen signaling of immune cells via estrogen receptor alpha (ERe0 and beta (ERL3) in mucosal inflammation. These projects will provide an ideal forum for the training of individuals in mouse pathobiology and enable them to initiate careers in research and become leaders in this field.

描述（由申请人提供）：随着基因工程小鼠模型的爆炸式增长，小鼠病理生物学家在生物医学研究中有巨大的机会。首席研究员的职业目标是成为一名更加独立和成功的小鼠病理生物学研究人员，并利用现有技能以及通过本提案开发的技能来指导下一代小鼠病理生物学家。他作为一名科学家的成长受到了与服务、行政和教学职责相关的时间限制的阻碍。这个奖项将使他从这些责任中解脱出来，并将时间重新分配到其他责任中，使他能够有更多的专注和深入的研究时间。由于他在训练和病理方面的广泛背景，他在独立和合作研究方面的经验以及他促进和促进小鼠病理生物学研究和训练的环境，该候选人非常有资格获得这一奖项。这个环境包括一个比较医学培训计划，一个世界知名的研究动物诊断实验室，一个比较医学研究中心和四个突变小鼠区域资源中心之一。长期研究目标包括揭示慢性肠道炎症疾病的机制，从而最终开发出新的预防和治疗策略。本提案的目标集中在肠粘膜炎症性疾病的男性和女性之间的差异。为了实现这些目标，将采用以下具体目标：1)确定A/J小鼠肝芽胞杆菌引起的粘膜炎症的细胞类型特征；2)评估性腺类固醇激素，雌激素和睾酮在细菌引发的粘膜炎症发病机制中的作用；3)评估免疫细胞通过雌激素受体α (ERe0和β (ERL3)的雌激素信号传导在粘膜炎症中的作用。这些项目将为培养小鼠病理生物学方面的个人提供一个理想的论坛，使他们能够开始研究事业，并成为该领域的领导者。