University of Wisconsin Regional Coordinating Center (UW RCC)

描述（由申请人提供）：威斯康星大学麦迪逊分校区域协调中风中心（UW RCC）将支持国家NIH中风试验的区域组织。这将包括预防、治疗和康复。这个RCC基础设施将建立在已经建立的威斯康星健康研究网络（WiNHR）的基础上，这是一个由美国国立卫生研究院赞助的研究联盟，包括学术、城市、农村、服务不足和健康差异人群。它包括四个主要的卫生系统，每年总共有1270万门诊人次。除了WiNHR网络外，还招募了26个其他卫生实体参与该RCC，其中包括美洲土著社区。在数据关联、研究协调和CTSA基础设施方面的经验将确保创新培训和努力的成功。我们在合作研究方面的经验将促进临床前和临床试验的转化，以及招募中风患者的成熟能力。神经外科、血管神经病学、神经外科、介入神经放射学、神经重症监护、中风康复、急诊医学、儿科神经病学和创新神经影像学的整合将提高生产力。通过研究者发起的卒中研究、培训和试验设计，我们建议加强卒中研究的整体国家计划，而不是简单地管理试验。我们的计划是：1)通过与卫星医院的合作，改善急性中风的院前计划。2)利用已建立的网络，如威斯康星健康研究网络（WiNHR）、健康公平合作中心（CCHE）、社区健康联系（CHC）和扩大的中风从未享受我们临床试验中不同的患者群体。3)在院前、卫星医院和三级转诊医院设置的护理规范方面教育提供者。4)通过威斯康星大学现有基础设施（包括合作与过渡研究研究所（ICTR）、临床试验办公室（OCT）和iVIobiie研究小组（MRT））中可用的试验方案和数据管理专家，改善卫星医院的临床、IRB和数据管理基础设施。

DESCRIPTION (provided by applicant): The University of Wisconsin-Madison Regional Coordinating Stroke Center (UW RCC) wiii support the regional organization of national NIH Stroke Trials. This will include prevention, treatment, and recovery. This RCC infrastructure will be based on the already established Wisconsin Network for Health Research (WiNHR), an NIH-sponsored research consortium including academic, urban, rural, and underserved and health disparity populations. It includes four major health systems with a total of 12.7 million outpatien visits per year. In addition to the WiNHR network, 26 additional health entities have been recruited for participation in this RCC including Native American communities. Experience in data correlation, study coordination, and CTSA infrastructure, will assure innovative training and success in the effort. Our experience in collaborative research will foster translation of preclinical and clinical trials, as well as a proven ability to recruit stroke patients. This integation of neurosurgery, vascular neurology, neurosurgery, interventional neuroradiology, neuro-intensive care, stroke rehabilitation, emergency medicine, pediatric neurology, and innovative neuro- imaging will enhance productivity. Through investigator initiated stroke research, training and trial design, we propose to enhance the overall national programs in stroke research rather than simply manage trials. Our plan is: 1) to improve the pre-hospital plan for acute stroke through collaborations with satellite hospitals. 2) To utilize established networks such as the Wisconsin Network for Health Research (WiNHR), Collaborative Center for Health Equity (CCHE), Community Health Connections (CHC), and expanding Telestroke never for enjoyment of our diverse patient population in clinical trials. 3) To educate providers across the care spec aim at the pre-hospital, satellite hospital, and tertiary referral hospital setting. 4) To improve clinical, IRB,-and data management infrastructure for satellite hospitals through trial protocol and data management experts available within existing infrastructure at the University of Wisconsin including the Institute for Collaborative and Transitional Research (ICTR), Office of Clinical Trials (OCT), and the iVIobiie Research Team (MRT).