CAROTID OCCLUSION SURGERY STUDY (COSS)

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目及 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 (from ClinicalTrials.gov网站） 这项研究的总体目的是确定一种名为“颅外-颅内搭桥术”的外科手术是否可以减少颈部一条主要动脉（颈动脉）完全阻塞的人随后中风的机会，该动脉为大脑供血，并且已经遭受了小中风。这种手术包括从颅骨外的头皮上取下一根动脉，在颅骨上开一个小孔，然后将头皮动脉与颅骨内的脑动脉连接起来。通过这种方式，颈部颈动脉的阻塞被绕过，更多的血液可以流向大脑。在一些人中，天然的旁路动脉发育，大脑已经获得了充足的血液。这些人如果服药，中风的风险很低。在其他人中，没有天然的旁路动脉发育，因此流向大脑的血液较少。第二组在服药期间中风的风险要高得多，在未来两年内高达25-50%。这是第二组人谁可能受益于有旁路手术，谁是本研究的候选人。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. (from ClinicalTrials.gov website) The overall purpose of this research is to determine if a surgical operation called "Extracranial-Intracranial Bypass" can reduce the chance of a subsequent stroke in someone who has complete blockage in one main artery in the neck (the carotid artery) that supplies blood to the brain and has already suffered a small stroke. This surgery involves taking an artery from the scalp outside the skull, making a small hole in the skull and then connecting the scalp artery to a brain artery inside the skull. In this way the blockage of the carotid artery in the neck is bypassed and more blood can flow to the brain. In some people natural bypass arteries develop and the brain is already getting plenty of blood. These people have a low risk of stroke if they take medicine. In other people, no natural bypass arteries develop so less blood flows to their brains. This second group has a much higher risk of stroke while taking medicine, as high as 25-50% within the next two years. It is this second group of people who may benefit from having the bypass operation and who are the candidates for this study.