NINDS Stroke Trials Network - Regional Coordinating Stroke Centers (U10)

描述(申请人提供)：中风是一种毁灭性的疾病，是美国和世界范围内的主要公共卫生负担。人们越来越需要加快发现有效的治疗方法，以便在临床实践中使用，以最大限度地减少这种负担。循证实践依赖于在多中心临床试验中进行的严格的科学方法。NINDS卒中试验网络-区域协调卒中中心(RFA-NS-13-011)为开发、促进和进行高质量的多地点临床试验提供了一种新的机制，这些试验侧重于卒中预防、治疗和康复方面的关键干预措施。该项目的具体目标是：1)建立卒中试验和研究-东南合作(STAR-SEC)网络，以加速招募加入NINDS赞助的针对急性卒中患者、复发卒中风险人群和卒中恢复者的临床试验；2)开发和建议在NINDS卒中试验网络内进行的新的、创新的卒中临床试验；以及3)增加对有前途的年轻研究人员的培训机会，这些研究人员将感兴趣的临床卒中研究作为职业。成功实施STAR-SEC网络的战略涵盖了从院前到康复的连续中风护理，拥有护理所有方面的专业知识，并证明有能力在疾病谱上的所有时间点招收受试者。这项建议建立在六年来作为NINDS赞助的神经治疗试验网络(NETT)的领先枢纽站点以及经验丰富的临床研究人员团队在多个NIH和行业赞助的随机临床试验(RCT)急性卒中、二级预防和卒中恢复方面密切合作的基础上。

DESCRIPTION (provided by applicant): Stroke is a devastating disease and a major public health burden in the US and worldwide. There is an increasing need to accelerate discovery of effective treatment for use in clinical practice to minimize this burden. Evidence based practice depends on rigorous scientific methods conducted in multi-center clinical trials. The NINDS Stroke Trials Network - Regional Coordinating Stroke Centers (RFA-NS-13-011) provides a new mechanism for developing, promoting and conducting high-quality, multi-site clinical trials focused on key interventions in stroke prevention, treatment and recovery. The Specific Aims of this project are to: 1) establish the Stroke Trials And Research - South Eastern Collaborative (STAR-SEC) network to accelerate recruitment into NINDS-sponsored clinical trials for patients with acute stroke, people at risk for recurrent stroke and individuals recovering from stroke; 2) develop and propose new and innovative clinical trials in stroke to be conducted within the NINDS Stroke Trials Network; and 3) enhance the training opportunities for promising young investigators interested in clinical stroke research as a career. The strategy for successful implementation of the STAR-SEC network covers the continuum of stroke care from pre-hospital through rehabilitation with expertise in all facets of care and proven ability to enroll subjects at all points along the disease spectrum. This proposal builds on 6 years of highly successful participation as a leading hub site in the NINDS-sponsored Neurological Treatment Trials Network (NETT) and as a team of experienced clinical investigators working closely together on multiple NIH and industry sponsored randomized clinical trials (RCT) in acute stroke, secondary prevention, and stroke recovery.