NINDS Stroke Trials Network - Regional Coordinating Stroke Centers (U10)

描述（由申请人提供）：卒中是一种毁灭性疾病，是美国和全球的主要公共卫生负担。越来越需要加速发现用于临床实践的有效治疗方法，以最大限度地减少这种负担。循证医学实践依赖于在多中心临床试验中进行的严格的科学方法。NINDS卒中试验网络-区域协调卒中中心（RFA-NS-13-011）提供了一种新的机制，用于开发、推广和开展高质量的多中心临床试验，重点关注卒中预防、治疗和康复的关键干预措施。该项目的具体目标是：1）建立中风试验和研究-东南合作（STAR-SEC）网络，以加速招募急性卒中患者，复发性卒中风险人群和卒中恢复个体的NINDS申办的临床试验; 2）开发并提出在NINDS卒中试验网络内进行的新的和创新的卒中临床试验; 3）增加对有兴趣从事临床中风研究的年轻研究人员的培训机会。成功实施STAR-SEC网络的策略涵盖了从院前到康复的中风护理的连续性，具有护理各个方面的专业知识，并证明了在疾病谱的所有沿着点招募受试者的能力。该提案建立在6年来作为NINDS赞助的神经治疗试验网络（NETT）的领先中心站点以及经验丰富的临床研究者团队在多项NIH和行业赞助的急性卒中，二级预防和卒中恢复随机临床试验（RCT）中密切合作的基础上。

DESCRIPTION (provided by applicant): Stroke is a devastating disease and a major public health burden in the US and worldwide. There is an increasing need to accelerate discovery of effective treatment for use in clinical practice to minimize this burden. Evidence based practice depends on rigorous scientific methods conducted in multi-center clinical trials. The NINDS Stroke Trials Network - Regional Coordinating Stroke Centers (RFA-NS-13-011) provides a new mechanism for developing, promoting and conducting high-quality, multi-site clinical trials focused on key interventions in stroke prevention, treatment and recovery. The Specific Aims of this project are to: 1) establish the Stroke Trials And Research - South Eastern Collaborative (STAR-SEC) network to accelerate recruitment into NINDS-sponsored clinical trials for patients with acute stroke, people at risk for recurrent stroke and individuals recovering from stroke; 2) develop and propose new and innovative clinical trials in stroke to be conducted within the NINDS Stroke Trials Network; and 3) enhance the training opportunities for promising young investigators interested in clinical stroke research as a career. The strategy for successful implementation of the STAR-SEC network covers the continuum of stroke care from pre-hospital through rehabilitation with expertise in all facets of care and proven ability to enroll subjects at all points along the disease spectrum. This proposal builds on 6 years of highly successful participation as a leading hub site in the NINDS-sponsored Neurological Treatment Trials Network (NETT) and as a team of experienced clinical investigators working closely together on multiple NIH and industry sponsored randomized clinical trials (RCT) in acute stroke, secondary prevention, and stroke recovery.