SECONDARY PREVENTION OF SMALL, SUBCORTICAL STROKE (SPS3)

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。本研究的目的是确定有效的治疗方法，以预防症状性小皮质下卒中患者的卒中复发和认知能力下降。假设联合抗血小板治疗相对于阿司匹林治疗可减少25%的卒中复发。与常规治疗相比，积极降低血压可使卒中复发率降低25%。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The aim of this study is to define efficacious therapies for prevention of stroke recurrence and cognitive decline in patients with symptomatic small subcortical stroke. The hypothesis is that combined antiplatelet therapy will reduce recurrent stroke by 25% relative to aspirin therapy along. Aggressive blood pressure lowering will reduce recurrent stroke by 25% relative to usual management.