STROKENET REGIONAL COORDINATING CENTER Georgia StrokeNet

这项提议的具体目标是：1)通过以下方式加强佐治亚州StrokeNet的成功使命 加速招募NIH StrokeNet急性中风患者和高危人群进行临床试验 针对复发性中风和中风康复者；2)开发和提出新的和创新的 将在NIH StrokeNet内进行中风临床试验；以及3)加强培训 为对临床中风研究感兴趣的有前途的年轻研究人员提供机会。 作为目前资助的NIH StrokeNet区域协调中心(RCC)，佐治亚州StrokeNet带来了 建立了高度成功和协作的调查人员和协调员的基础设施，已有多年 在设计、实施和招募患者参加随机临床试验方面的成熟专业知识 从入院前到康复的中风护理的连续不断。我们的RCC已经证明了有能力 使用主试验协议和中央IRB快速实施研究方案，并已将 现有的网络强大的领导能力，证明了我们的团队成员的积极和持续的参与 在NIH StrokeNet工作组中，包括NIH StrokeNet康复工作组联合主席和 自实施以来，急性中风工作组中唯一的项目协调员代表。埃默里的 佐治亚州StrokeNet计划建立在我们RCC 5年来非常成功地参与的记录基础上，作为 NIH StrokeNet网站，10年来作为NINDS赞助的神经治疗试验的顶级参与者 网络(NETT)，最近被选为NIH资助的仅有的11个SIREN(创新战略)中心之一 急诊)临床试验网络，以及在多个NIH和行业中高注册的25年历史 赞助实践改变中风的随机临床试验。

The Specific Aims of this proposal are to: : 1) enhance the successful mission of the Georgia StrokeNet by accelerating recruitment into NIH StrokeNet clinical trials for patients with acute stroke, people at risk for recurrent stroke and individuals recovering from stroke; 2) develop and propose new and innovative clinical trials in stroke to be conducted within the NIH StrokeNet; and 3) enhance the training opportunities for promising young investigators interested in clinical stroke research as a career. As a currently-funded NIH StrokeNet Regional Coordinating Center (RCC), the Georgia StrokeNet brings an established infrastructure of highly successful and collaborative investigators and coordinators, with many years of proven expertise in designing, conducting, and enrolling patients into randomized clinical trials across the continuum of stroke care, from pre-hospital through rehabilitation. Our RCC has demonstrated the ability to quickly implement research protocols using master trial agreements and a central IRB, and has brought to the existing network strong leadership skills, as evidenced by our team members’ active and ongoing participation in NIH StrokeNet working groups including Co-Chair of the NIH StrokeNet’s Rehabilitation working group and the only Project Coordinator representation in the Acute Stroke Working Group since implementation. Emory’s Georgia StrokeNet proposal builds upon our RCC’s track record of 5 years of highly successful participation as an NIH StrokeNet site, 10 years as a top enroller for the NINDS-sponsored Neurological Treatment Trials Network (NETT), recent selection as one of only 11 hubs for the NIH-funded SIREN (Strategies to Innovate EmeRgENcy Care) Clinical Trials Network, and a 25 year history of high enrollment in multiple NIH and industry sponsored practice changing randomized clinical trials in stroke.