HERCULES: Health and Exposome Research Center at Emory

描述（由申请人提供） HERCULES P30（健康与暴露组研究中心：了解终生暴露）的愿景是让暴露组在临床和公共卫生环境中获得与基因组同等的地位。研究人员相信，对这种简单而统一的视觉的追求将刺激发现，促进合作，并加强埃默里大学环境健康科学领域的交流。 研究人员计划利用 P30 机制营造一种促进创新、协作和进步的知识氛围。具体来说，他们计划加强埃默里大学的合作研究，包括增加校外资金、为当地和区域社区提供环境问题信息来源，并通过前沿研究对国家和全球层面产生影响。为此，研究人员提出了以下具体目标，这些目标与其使用暴露组相关概念和方法改善人类健康的主题相一致： 具体目标 1：通过核心、试点资助和研究论坛，提供更多接触暴露组相关方法（系统生物学、代谢组学、高通量毒理学、空间和时间统计模型）的机会。 具体目标 2：为暴露组的操作定义做出重大贡献（促进团队科学文化、试点资助、开展暴露组相关研究）。 具体目标 3：围绕与暴露相关的创新和新兴概念和方法提供职业发展活动。 具体目标 4：加强和扩大与社区合作伙伴的现有关系，以利用暴露组原则促进环境因素在疾病中的重要性的沟通。具体目标 5：提供基础设施和资源，以促进新的科学发现快速转化为人类新的可持续性、预防或治疗策略的开发。该中心的组织结构在战略愿景部分的 HERCULES 逻辑模型中进行了描述。执行委员会将以这些目标为指导，并使用逻辑模型来监控中心的进展。

DESCRIPTION (provided by applicant) The vision of the HERCULES P30 (Health and Exposome Research Center: Understanding Lifetime Exposures) is for the exposome to gain equal footing to the genome in clinical and public health settings. The investigators believe that the pursuit of this simple and unifying visin will stimulate discovery, promote collaboration, and enhance communication in Environmental Health Sciences at Emory University. The investigators plan to use the P30 mechanism to create an intellectual climate that fosters innovation, collaboration, and progress. Specifically, they plan to enhance collaborative research at Emory, including increasing extramural funding, serving the local and regional community as a source for information on environmental issues, and to make an impact on the national and global level through cutting-edge research. To do this the investigators propose the following specific aims that align with their theme of using exposome-related concepts and approaches to improve human health: Specific Aim 1: Provide greater access to exposome-related approaches (systems biology, metabolomics, high throughput toxicology, spatial and temporal statistical models) through cores, pilot funding, and research forums. Specific Aim 2: Make major contributions towards the operational definition of the exposome (promoting a culture of team science, pilot funding, pursuing exposome-related research). Specific Aim 3: Provide career development activities around innovative and emerging concepts and approaches related to exposome. Specific Aim 4: Enhance and expand existing relationships with community partners to facilitate communication of the importance of environmental factors in disease using exposome principles. Specific Aim 5: Provide infrastructure and resources to facilitate rapid translation of novel scientific findings ito the development of novel sustainability, prevention or treatment strategies in humans. The organization of the Center is depicted in the HERCULES Logic Model in the strategic vision section. The Executive Committee will be guided by these aims and use the Logic Model to monitor progress of the Center.