HERCULES: Health and Exposome Research Center at Emory

描述（由申请人提供） HERCULES P30（健康与暴露体研究中心：了解终身暴露）的愿景是让疾病在临床和公共卫生环境中获得与基因组平等的地位。研究人员认为，追求这种简单而统一愿景将刺激发现，促进合作，并加强埃默里大学环境健康科学的交流。 研究人员计划使用P30机制来创造一个促进创新、协作和进步的知识氛围。具体来说，他们计划加强埃默里大学的合作研究，包括增加校外资金，为当地和区域社区提供环境问题的信息来源，并通过尖端研究在国家和全球层面产生影响。为了做到这一点，研究人员提出了以下具体目标，这些目标与他们的主题相一致，即使用与生物体相关的概念和方法来改善人类健康：具体目标1：通过核心，试点资金和研究论坛，提供更多与生物体相关的方法（系统生物学，代谢组学，高通量毒理学，空间和时间统计模型）。 具体目标二：对困难组的业务定义作出重大贡献（促进团队科学文化，试点资金，进行困难组相关研究）。 具体目标3：围绕与麻烦有关的创新和新兴概念和方法开展职业发展活动。 具体目标4：加强和扩大与社区合作伙伴的现有关系，以促进使用麻烦的原则在疾病中的环境因素的重要性的沟通。具体目标五：提供基础设施和资源，以促进新的科学发现迅速转化为人类新的可持续性，预防或治疗策略的发展。该中心的组织结构在战略愿景部分的HERCULES逻辑模型中描述。执行委员会将以这些目标为指导，并使用逻辑模型来监测中心的进展情况。

DESCRIPTION (provided by applicant) The vision of the HERCULES P30 (Health and Exposome Research Center: Understanding Lifetime Exposures) is for the exposome to gain equal footing to the genome in clinical and public health settings. The investigators believe that the pursuit of this simple and unifying visin will stimulate discovery, promote collaboration, and enhance communication in Environmental Health Sciences at Emory University. The investigators plan to use the P30 mechanism to create an intellectual climate that fosters innovation, collaboration, and progress. Specifically, they plan to enhance collaborative research at Emory, including increasing extramural funding, serving the local and regional community as a source for information on environmental issues, and to make an impact on the national and global level through cutting-edge research. To do this the investigators propose the following specific aims that align with their theme of using exposome-related concepts and approaches to improve human health: Specific Aim 1: Provide greater access to exposome-related approaches (systems biology, metabolomics, high throughput toxicology, spatial and temporal statistical models) through cores, pilot funding, and research forums. Specific Aim 2: Make major contributions towards the operational definition of the exposome (promoting a culture of team science, pilot funding, pursuing exposome-related research). Specific Aim 3: Provide career development activities around innovative and emerging concepts and approaches related to exposome. Specific Aim 4: Enhance and expand existing relationships with community partners to facilitate communication of the importance of environmental factors in disease using exposome principles. Specific Aim 5: Provide infrastructure and resources to facilitate rapid translation of novel scientific findings ito the development of novel sustainability, prevention or treatment strategies in humans. The organization of the Center is depicted in the HERCULES Logic Model in the strategic vision section. The Executive Committee will be guided by these aims and use the Logic Model to monitor progress of the Center.