Prenatal Sex Steroids, Bisphenol A, Phthalates, and Sexually Dimorphic Behaviors

产前性类固醇、双酚 A、邻苯二甲酸盐和性别二态行为

• 批准号: 8587520
• 负责人: Joseph M Braun
• 金额: $ 20.1万
• 依托单位: BROWN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-02-14 至 2016-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8587520
• 关键词: 8 year old; 9 year old; Address; Affect; Aggressive behavior; Amniotic Fluid; Androgens; Androstenedione; Animals; Archives; Area; Attention deficit hyperactivity disorder; Attenuated; Autistic Disorder; Award; Behavior; Behavioral; Biological; Biological Markers; Birth; Boston; Brain; Chemicals; Child; Childhood; Clinical; Data; Disease; Endocrine Disruptors; Endocrine system; Endocrinology; Environment; Epidemiologist; Epidemiology; Estradiol; Estrogens; Estrone; Exposure to; Female; Fetal Development; Gonadal Steroid Hormones; Health; Human; Individual; Infant; Institution; Instruction; Intervention; Knowledge; Learning; Learning Disabilities; Measures; Meconium; Mediating; Medical; Memory; Mental Depression; Mentors; Mentorship; Methods; Nature; Outcome; Outcome Measure; Pathway interactions; Performance; Perinatal Exposure; Phase; Play; Population; Pregnancy; Pregnant Women; Process; Psychometrics; Public Health; Radial; Reproductive Health; Research; Research Personnel; Research Project Grants; Research Training; Resources; Risk; Rodent; Role; Sampling; Sex Characteristics; Short-Term Memory; Testing; Testosterone; Time; Toxicant exposure; Training; Umbilical Cord Blood; United States; Urine; Validation; Visuospatial; Work; abstracting; analog; arm; bisphenol A; career; cohort; computerized; critical period; environmental chemical; environmental chemical exposure; experience; fetal; improved; male; morris water maze; multidisciplinary; neurobehavior; neurobehavioral; neurobehavioral disorder; neurobehavioral test; neurodevelopment; neurotoxicity; novel; performance tests; phthalates; prenatal; prospective; public health relevance; sex; skills; symposium; urinary; virtual

Abstract: The fetal brain is uniquely sensitive and environmental chemical exposures and dysregulation of the endocrine system may increase the risk of adverse neurobehavioral outcomes like autism, attention-deficit/hyperactivity disorder, or depression. Under the mentorship of Drs. Bellinger and Hauser, this training and research plan will build upon Dr. Braun's expertise as an environmental epidemiologist and prepare him for a career studying endocrine disrupting compounds (EDCs) and their impact on hormonal systems and childhood neurodevelopment. Dr. Braun has never received formal training in these areas and few researchers possess this unique cross-disciplinary expertise. During the K99-phase of this award Dr. Braun will use tutorials, seminars/conferences, and didactic instruction to gain additional training in: 1) endocrinology concepts and the impact of environmental chemicals on the endocrine system; 2) psychometric test selection, administration, validation, and interpretation; and 3) childhood neurodevelopment. This training will be applied in an original research project where Dr. Braun will administer computerized tests of visuospatial ability to 25 children from Dr. Hauser's Environment and Reproductive Health (EARTH) study under the guidance of both Drs. Hauser and Bellinger. These computerized tests are analogues of the Morris Water Maze and Radial Arm Maze, which are used in animal studies of neurotoxicity. Using these new skills and the prospective Health Outcomes and Measures of the Environment (HOME) birth cohort, Dr. Braun will address two specific aims during the R00- phase of this award: 1) determine if gestational BPA/phthalate exposure is associated with visuospatial ability in 300 children and if sex modifies these associations and 2) determine if gestational BPA/phthalate exposure is associated with meconium sex steroid concentrations in 330 infants. Dr. Braun is well suited to carry out this research because of his prior training and the unique resources offered by his mentors, advisors, and institution. This proposed training and research will enable him to study the impact of EDCs on other hormonal systems and whether they increase the risk of adverse childhood behavioral outcomes. The examination of sex steroids will advance our knowledge of potential biological mechanisms of EDC action and the use of neurobehavioral tests with animal analogues will improve comparisons between epidemiological and animal studies.

摘要： 胎儿的大脑是独特的敏感和环境的化学暴露和失调的内分泌 系统可能会增加不良神经行为结果的风险，如自闭症，注意力缺陷/多动 失调或抑郁症。在Bellinger和豪瑟博士的指导下，本培训和研究计划将 以布劳恩博士作为环境流行病学家的专业知识为基础， 内分泌干扰化合物（EDCs）及其对激素系统和儿童的影响 神经发育布劳恩博士从未接受过这些领域的正式培训，也很少有研究人员拥有这些技能。 这种独特的跨学科专业知识。在K99阶段，布劳恩博士将使用教程， 研讨会/会议和教学指导，以获得以下方面的额外培训：1）内分泌学概念和 环境化学物质对内分泌系统的影响; 2）心理测试的选择，管理， 验证和解释; 3）儿童神经发育。本培训将以原始 研究项目，布劳恩博士将管理视觉空间能力的计算机测试，25名儿童从 博士豪瑟的环境和生殖健康（地球）研究的指导下，博士豪瑟 还有贝林格这些计算机化测试类似于莫里斯水迷宫和桡臂迷宫， 用于神经毒性的动物研究。利用这些新技能和预期的健康结果， 环境措施（HOME）出生队列，布劳恩博士将在R 00期间解决两个具体目标- 该奖项的阶段：1）确定妊娠期BPA/邻苯二甲酸酯暴露是否与视觉空间能力相关 在300名儿童中，如果性别改变了这些关联，2）确定妊娠期BPA/邻苯二甲酸酯暴露是否 与330名婴儿的胎粪性类固醇浓度有关。布劳恩博士很适合做这个 研究，因为他以前的培训和他的导师，顾问提供的独特资源， 机构。这项拟议的培训和研究将使他能够研究内分泌干扰物对其他激素的影响， 系统以及它们是否会增加不良儿童行为后果的风险。对性的审视 类固醇将促进我们对EDC作用的潜在生物学机制的了解， 用动物类似物进行神经行为测试将改善流行病学和动物之间的比较。 问题研究