Maternal and Paternal Preconception Environmental Exposures and Children's Health

母亲和父亲的孕前观念 环境暴露与儿童健康

• 批准号: 10321564
• 负责人: Joseph M Braun
• 金额: $ 59.48万
• 依托单位: HARVARD SCHOOL OF PUBLIC HEALTH
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-01-01 至 2024-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10321564
• 关键词: 10 year old; Accounting; Affect; Age; Animals; Anthropometry; Biological; Biometry; Body Composition; Boston; Chemicals; Child; Child Health; Child Welfare; Childhood; Clinic; Cognition; Cohort Studies; Conceptions; Couples; Data; Diet; Disease; Embryo; Endocrine Disruptors; Environment; Environmental Epidemiology; Environmental Exposure; Epidemiology; Epigenetic Process; Exposure to; Family; Fathers; Fertility; Financial cost; Food; Future Generations; General Hospitals; General Population; Germ Cells; Glucose; Health; Heritability; Homeostasis; Human; Impairment; Individual; Insulin; Joints; Life; Lipids; Literature; Massachusetts; Measures; Medical History; Modification; Mothers; Neurodevelopmental Disorder; Obesity; Outcome; Personal Satisfaction; Persons; Pharmaceutical Preparations; Phenotype; Plastics; Play; Pregnancy; Problem behavior; Prospective cohort; Public Health; Reproductive Health; Research; Research Personnel; Risk; Risk Factors; Roentgen Rays; Role; Sampling; Satiation; Serum; Smoking; Stress; Triad Acrylic Resin; Twin Multiple Birth; Urine; Visit; Woman; blood pressure elevation; cardiometabolic risk; cardiometabolism; caregiving; cognitive ability; cohort; consumer product; cost effective; disorder risk; early childhood; environmental chemical exposure; epidemiologic data; epidemiology study; executive function; experimental study; follow-up; hormonal signals; improved; innovation; male; modifiable risk; mother nutrition; multidisciplinary; neurobehavior; neurobehavioral; neurodevelopment; novel; obesity in children; obesity risk; offspring; personal care products; phthalates; prenatal; prospective; sedentary activity; sperm cell

Abstract Childhood obesity, cardiometabolic abnormalities, and neurodevelopmental disorders are prevalent, impact the health and well-being of children and their families, and have substantial financial costs. Research demonstrates that early life environmental exposures increase the risk of these disorders. While there has been justifiable emphasis on studying environmental exposures during gestation and early childhood, there is limited epidemiologic data on the impact of maternal preconception exposures on children’s health and even less research on the effect of paternal preconception exposures. Experimental studies in animals provide compelling data showing that maternal and paternal preconception exposures to stress and altered diet affect offspring phenotypes through heritable epigenetic modifications encoded in gametes. Despite support for the scientific premise that preconception environmental exposures have the potential to affect children’s health, there is an almost complete lack of human studies. Endocrine disrupting chemicals are of particular concern because they disrupt hormonal signaling and alter epigenetic programming of gametes and embryos, which in turn may adversely affect child health. One class of chemicals of high concern is phthalates, multifunctional chemicals used in many consumer products and for which there is ubiquitous general population exposure. Our multidisciplinary team of investigators proposes a new study of children who were born to couples who participated in our ongoing prospective preconception cohort study. We previously analyzed multiple urine samples for phthalate metabolites from mothers and fathers before conception and from women during pregnancy. In this proposal, we will conduct in-person visits on 381 eligible children (7-10 years of age) and collect detailed measures of child neurobehavior, anthropometry, and cardiometabolic function. We have collected or will collect extensive maternal, paternal, and child-level covariate data, including diet, SES, medical history, caregiving environment, and physical/sedentary activity. Our specific aims are to determine the extent to which maternal and paternal preconception phthalate exposures are individually and/or jointly associated with: 1) increased behavior problems, poorer executive function, and reduced cognitive abilities, 2) increased adiposity and reduced satiety, 3) impaired glucose and insulin homeostasis, increased blood pressure, and altered serum lipids. Our innovative proposed study represents a unique opportunity to determine if maternal and paternal pre-conception phthalate exposure affects children’s health, while also controlling for prenatal and childhood phthalate exposure. Other innovations include the availability of multiple maternal and paternal preconception urine samples to assess phthalate exposure, state of the art assessment of child health outcomes, and use of novel statistical approaches to study phthalate mixtures and windows of vulnerability. Our proposed study will provide critical data on the effect of maternal and paternal preconception phthalate exposure on child health, and thus identify modifiable risk factors for prevalent childhood diseases.

摘要

项目成果

Paternal and maternal preconception and maternal pregnancy urinary phthalate metabolite and BPA concentrations in relation to child behavior.

父亲和母亲的孕前和母亲怀孕尿邻苯二甲酸酯代谢物和 BPA 浓度与儿童行为的关系。

• DOI: 10.1016/j.envint.2023.108337
• 发表时间: 2024
• 期刊: Environment international
• 影响因子: 11.8
• 作者: Leader,Jordana;Mínguez-Alarcón,Lidia;Williams,PaigeL;Ford,JenniferB;Dadd,Ramace;Chagnon,Olivia;Bellinger,DavidC;Oken,Emily;Calafat,AntoniaM;Hauser,Russ;Braun,JosephM
• 通讯作者: Braun,JosephM

The Effect of Deuteration and Homologation of the Lactam Ring of Nirmatrelvir on Its Biochemical Properties and Oxidative Metabolism.

• DOI: 10.1021/acsbiomedchemau.3c00039
• 发表时间: 2023-12-20
• 期刊: ACS BIO & MED CHEM AU
• 作者: Arutyunova, Elena;Belovodskiy, Alexandr;Chen, Pu;Khan, Muhammad Bashir;Joyce, Michael;Saffran, Holly;Lu, Jimmy;Turner, Zoe;Bai, Bing;Lamer, Tess;Young, Howard S;Vederas, John C;Tyrrell, D Lorne;Lemieux, M Joanne;Nieman, James A
• 通讯作者: Nieman, James A