Gestational PFAS Mixture Exposures, Longitudinal Metabolomic Profiles, and Adolescent Cardiometabolic Health
妊娠期 PFAS 混合物暴露、纵向代谢组学特征和青少年心脏代谢健康
基本信息
- 批准号:10673054
- 负责人:
- 金额:$ 56.63万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-09-25 至 2025-07-31
- 项目状态:未结题
- 来源:
- 关键词:12 year oldAccelerationAddressAdolescentAdolescent obesityAdultAffectAgeAmino AcidsAnalytical ChemistryAnimalsAreaBiologicalBiological MarkersBiometryBiostatistical MethodsBloodCanadaCardiometabolic DiseaseCardiovascular DiseasesCarnitineChemical ExposureChemicalsChildChildhoodCohort StudiesCollaborationsCollectionCommerceCoupledDataDatabasesDietDimensionsDissociationDyslipidemiasElderlyEnvironmentEpidemiologistEpidemiologyEvaluationExposure toFatty AcidsFire - disastersFoodFood ContaminationFood PackagingGrowthHealthHomeHumanHypertensionIndividualIndustryInsulin ResistanceIonsKnowledgeLifeLinkMeasuresMediatingMetabolicMetabolismModelingObesityOhioOilsOutcomePathway interactionsPediatricsPersonsPlasmaPoly-fluoroalkyl substancesPopulations at RiskPredispositionPregnancyPregnant WomenProductivityProspective cohortPublishingRecording of previous eventsRegulationResearch PersonnelResolutionRiskRisk FactorsSamplingSerumSyndromeTechniquesTestingTextilesTimeToxic effectTrainingUnited StatesWateradolescent healthblood pressure elevationcardiometabolic riskcardiometabolismcardiovascular disorder riskcontaminated drinking watercritical perioddisorder riskdrinking waterearly adolescenceearly life exposureenvironmental chemicalenvironmental chemistryhealth assessmentimprovedinnovationlandfillliquid chromatography mass spectrometrymanufacturemanufacturing facilitymaternal serummetabolomemetabolomicsmicrobiomeneonatenovelobesity riskprenatalprenatal exposureresponsesmall molecule
项目摘要
Project Abstract
Exposure to environmental chemical mixtures may increase the risk of cardiometabolic disease. Of particular
concern are prenatal exposure to perfluoroalkyl substances (PFAS), a class of chemicals used as processing
aids for oil/water repellant textiles, fluoropolymer manufacturing, food packaging, cleaning products, and
firefighting foams. PFAS exposure is ubiquitous, deriving from contaminated food and drinking water. Over 6
million people in the US have PFAS contaminated drinking water, and many more have low-level exposure.
Animal and human studies show that prenatal PFAS exposure may increase the risk of obesity, insulin
resistance, dyslipidemia, and hypertension – components of the cardiometabolic syndrome that markedly
increase the risk of adulthood cardiovascular diseases. However, few studies have investigated the health
effects of PFAS mixtures, and the biological pathways underlying these effects are poorly understood. Guided
by our preliminary studies and the hypothesis that biological pathways represented in the serum metabolome
are sensitive to early life PFAS mixture exposure and predictive of later life cardiometabolic health, we will use
non-targeted high-resolution metabolomics to quantify the associations between prenatal PFAS mixtures, the
metabolome, and cardiometabolic disease. Building upon two established and ongoing prospective cohorts of
pregnant women and their children from Canada (MIREC Study, n=500) and Cincinnati, Ohio (HOME Study,
n=250), we will measure >25,000 features of the serum metabolome at delivery and ages 3-5, and 7-12 years.
We will link these data to previously collected or to be measured prenatal PFAS biomarkers and
cardiometabolic outcomes at age 7-12 years. We will use sophisticated biostatistical techniques to reduce the
dimensionality of these data and discover metabolomic signatures associated with both prenatal PFAS
mixtures and cardiometabolic outcomes in MIREC, replicating our findings using HOME. Specifically, we will:
1) characterize trajectories of the serum metabolome in the first 12 years of life; 2) identify features of serum
metabolome trajectories in the first 12 years of life that predict adolescent cardiometabolic disease; 3)
determine if metabolome features mediate the association of prenatal exposure to PFAS mixtures with
adolescent cardiometabolic disease; and 4) determine the chemical identity of metabolome features
discovered in Aim 3. This interdisciplinary proposal that includes epidemiologists, clinicians, biostatisticians,
and chemists will efficiently leverage two ongoing cohort studies to address these timely aims. Ultimately, the
proposed studies will have substantial impact by improving our knowledge of the health effects of PFAS,
identifying novel metabolic alterations associated with PFAS mixtures and adolescent health, and improving
our understanding of biological pathways affecting cardiometabolic disease. These results are critical to
ongoing evaluations of PFAS toxicity and may help identify exposed populations at risk of cardiometabolic
disease and potentially ameliorate the effects of PFAS exposure.
项目摘要
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Joseph M Braun其他文献
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{{ truncateString('Joseph M Braun', 18)}}的其他基金
Annual Retreat of the International Society for Environmental Epidemiology
国际环境流行病学学会年度务虚会
- 批准号:
10682974 - 财政年份:2023
- 资助金额:
$ 56.63万 - 项目类别:
A Residential Dust Control Intervention to Reduce Early Childhood Exposure toChemical Mixtures
住宅灰尘控制干预措施,以减少幼儿接触化学混合物
- 批准号:
10662226 - 财政年份:2022
- 资助金额:
$ 56.63万 - 项目类别:
A Residential Dust Control Intervention to Reduce Early Childhood Exposure toChemical Mixtures
住宅灰尘控制干预措施,以减少幼儿接触化学混合物
- 批准号:
10426573 - 财政年份:2022
- 资助金额:
$ 56.63万 - 项目类别:
Gestational PFAS Mixture Exposures, Longitudinal Metabolomic Profiles, and Adolescent Cardiometabolic Health
妊娠期 PFAS 混合物暴露、纵向代谢组学特征和青少年心脏代谢健康
- 批准号:
10181188 - 财政年份:2021
- 资助金额:
$ 56.63万 - 项目类别:
Gestational PFAS Mixture Exposures, Longitudinal Metabolomic Profiles, and Adolescent Cardiometabolic Health
妊娠期 PFAS 混合物暴露、纵向代谢组学特征和青少年心脏代谢健康
- 批准号:
10494076 - 财政年份:2021
- 资助金额:
$ 56.63万 - 项目类别:
Maternal and Paternal Preconception Environmental Exposures and Children's Health
母亲和父亲的孕前观念 环境暴露与儿童健康
- 批准号:
10321564 - 财政年份:2018
- 资助金额:
$ 56.63万 - 项目类别:
Endocrine Disrupting Chemicals, Thyroid Hormones, and Child Neurobehavior
内分泌干扰化学物质、甲状腺激素和儿童神经行为
- 批准号:
8887432 - 财政年份:2015
- 资助金额:
$ 56.63万 - 项目类别:
Endocrine Disrupting Chemicals, Thyroid Hormones, and Child Neurobehavior
内分泌干扰化学物质、甲状腺激素和儿童神经行为
- 批准号:
9248209 - 财政年份:2015
- 资助金额:
$ 56.63万 - 项目类别:
Prenatal Sex Steroids, Bisphenol A, Phthalates, and Sexually Dimorphic Behaviors
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8587520 - 财政年份:2013
- 资助金额:
$ 56.63万 - 项目类别:
Prenatal Sex Steroids, Bisphenol A, Phthalates, and Sexually Dimorphic Behaviors
产前性类固醇、双酚 A、邻苯二甲酸盐和性别二态行为
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8300259 - 财政年份:2012
- 资助金额:
$ 56.63万 - 项目类别:
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