Training Grant in Teratology

畸胎学培训补助金

• 批准号: 8500263
• 负责人: Charles V Vorhees
• 金额: $ 24.81万
• 依托单位: CINCINNATI CHILDRENS HOSP MED CTR
• 依托单位国家: 美国
• 财政年份: 1977
• 资助国家: 美国
• 起止时间: 1977-07-01 至 2017-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8500263
• 关键词: Grant; Teratology; Training

DESCRIPTION (provided by applicant) The goal of this doctoral and postdoctoral training program is to educate scientists who will provide insights into the causes and prevention of birth defects and functional abnormalities of prenatal origin. Graduate students are selected from among the Molecular and Developmental Biology (MDB) Graduate Program matriculants with interest in birth defects and/or neurobehavioral effects of prenatal origin. MDB students take core classes in developmental biology, molecular genetics, cell biology, biochemistry, and ethics in research; teratology students additionally take courses in teratology, biostatistics, and toxicology (recommended). Neuroteratology students additionally take courses in neuroscience. Postdoctoral trainees take the teratology and ethics in research courses. Postdoctoral trainees enter the Training Program by applying directly to training faculty members. All training faculty operate active, extramurall funded laboratories and all have experience training graduate students and postdoctoral fellows. Current and past trainees show excellent research productivity, all attend national meetings annually, and all have secured good positions upon completion. All trainees in the last 10 years have remained in science; many have entered the private sector thereby helping to fill the national shortage of teratologists in industry. Four pre-doctoral and three postdoctoral positions are requested. During the current funding period, the program has had additional success attracting URM trainees; in addition, curriculum changes have strengthened training in molecular genetics, developmental biology, and developmental diseases; a new research building and core facilities became available and the MDB faculty has expanded to 85, with the training grant faculty expanding to 15, 5 of whom are new to the grant. More training investigators now investigate environmental agents than 5 years ago. This program fills a unique niche as the only NIEHS training grant in teratology, the only one with a molecular genetics emphasis, and the only one with major focus on brain development. Teratology is not a specialty with its own academic home; accordingly, training in molecular developmental biology and/or neurobiology in addition to teratology provides trainees with flexibility to enter scientifi careers in teratology, developmental toxicology, neurobehavioral teratology, developmental biology, or developmental neuroscience with equal facility. This renewal continues the strengths of the program from the past and adds new faculty and resources to move teratology training to the next level of understanding the prenatal origins of disorders and diseases.

描述（由申请人提供） 该博士和博士后培训计划的目标是教育科学家，让他们深入了解出生缺陷和产前功能异常的原因和预防。研究生是从对出生缺陷和/或产前神经行为影响感兴趣的分子与发育生物学（MDB）研究生项目的入学者中选出的。 MDB 学生学习发育生物学、分子遗传学、细胞生物学、生物化学和研究伦理学等核心课程；畸形学学生还学习畸形学、生物统计学和毒理学课程（推荐）。神经畸胎学学生还学习神经科学课程。 博士后学员在研究课程中学习畸胎学和伦理学。 博士后学员通过直接向培训教员申请进入培训计划。 所有培训教师都拥有活跃的校外资助实验室，并且都有培训研究生和博士后的经验。当前和过去的学员都表现出了出色的研究生产力，每年都参加全国会议，并且在完成后都获得了良好的职位。 过去10年里所有的学员都留在了科学领域；许多人进入了私营部门，从而帮助填补了全国工业畸胎学家的短缺。 4个博士前职位和3个博士后职位 被要求。 在当前资助期间，该计划在吸引 URM 学员方面取得了额外的成功；此外，课程改革加强了分子遗传学、发育生物学和发育疾病方面的培训；新的研究大楼和核心设施投入使用，MDB 教职人员已扩大到 85 名，培训资助教职人员扩大到 15 名，其中 5 名是新获得资助的教职人员。 现在，与五年前相比，更多的培训调查员开始调查环境因素。该项目填补了一个独特的空白，作为唯一的 NIEHS 畸胎学培训资助项目，唯一一个以分子遗传学为重点的项目，也是唯一一个主要关注大脑发育的项目。畸胎学并不是一门拥有自己学术地位的专业。因此，除了畸胎学之外，分子发育生物学和/或神经生物学的培训为受训者提供了进入畸胎学、发育毒理学、神经行为畸胎学、发育生物学或发育神经科学领域的科学职业的灵活性。此次更新延续了该计划过去的优势，并增加了新的师资和资源，将畸胎学培训提升到了解疾病的产前起源的新水平。