Training Grant in Teratology

描述（由申请人提供） 这个博士和博士后培训计划的目标是教育科学家，他们将提供有关出生缺陷和产前功能异常的原因和预防的见解。研究生是从分子和发育生物学（MDB）研究生课程的学生中挑选出来的，他们对出生缺陷和/或产前起源的神经行为影响感兴趣。 MDB学生参加发育生物学，分子遗传学，细胞生物学，生物化学和研究伦理学的核心课程;畸形学学生还参加畸形学，生物统计学和毒理学课程（推荐）。神经畸形学的学生还参加神经科学课程。 博士后研究生学习畸形学和伦理学研究课程。 博士后学员通过直接向培训教师申请进入培训计划。 所有培训教师都有积极的、由外部资助的实验室，并且都有培训研究生和博士后研究员的经验。目前和过去的受训人员表现出出色的研究生产力，所有参加国家会议每年，并在完成后都获得了良好的职位。 在过去10年中，所有受训人员都留在了科学界;许多人进入了私营部门，从而帮助填补了全国工业界畸形学家的短缺。 四个博士前和三个博士后职位 被要求。 在目前的资助期间，该计划取得了额外的成功，吸引了URM学员;此外，课程的变化加强了分子遗传学，发育生物学和发育疾病的培训;一个新的研究大楼和核心设施成为可用，MDB教师已扩大到85，培训补助金教师扩大到15，其中5人是新的补助金。 与5年前相比，现在有更多的受训调查员调查环境代理人。该计划填补了一个独特的利基作为唯一的NIEHS培训补助金在畸形学，唯一一个分子遗传学的重点，和唯一一个主要集中在大脑发育。畸形学不是一个有自己学术家的专业;因此，除了畸形学之外，分子发育生物学和/或神经生物学的培训为学员提供了进入畸形学，发育毒理学，神经行为畸形学，发育生物学或发育神经科学的科学职业的灵活性。这次更新延续了过去该计划的优势，并增加了新的教师和资源，将畸形学培训提升到了解疾病和疾病的产前起源的下一个水平。

DESCRIPTION (provided by applicant) The goal of this doctoral and postdoctoral training program is to educate scientists who will provide insights into the causes and prevention of birth defects and functional abnormalities of prenatal origin. Graduate students are selected from among the Molecular and Developmental Biology (MDB) Graduate Program matriculants with interest in birth defects and/or neurobehavioral effects of prenatal origin. MDB students take core classes in developmental biology, molecular genetics, cell biology, biochemistry, and ethics in research; teratology students additionally take courses in teratology, biostatistics, and toxicology (recommended). Neuroteratology students additionally take courses in neuroscience. Postdoctoral trainees take the teratology and ethics in research courses. Postdoctoral trainees enter the Training Program by applying directly to training faculty members. All training faculty operate active, extramurall funded laboratories and all have experience training graduate students and postdoctoral fellows. Current and past trainees show excellent research productivity, all attend national meetings annually, and all have secured good positions upon completion. All trainees in the last 10 years have remained in science; many have entered the private sector thereby helping to fill the national shortage of teratologists in industry. Four pre-doctoral and three postdoctoral positions are requested. During the current funding period, the program has had additional success attracting URM trainees; in addition, curriculum changes have strengthened training in molecular genetics, developmental biology, and developmental diseases; a new research building and core facilities became available and the MDB faculty has expanded to 85, with the training grant faculty expanding to 15, 5 of whom are new to the grant. More training investigators now investigate environmental agents than 5 years ago. This program fills a unique niche as the only NIEHS training grant in teratology, the only one with a molecular genetics emphasis, and the only one with major focus on brain development. Teratology is not a specialty with its own academic home; accordingly, training in molecular developmental biology and/or neurobiology in addition to teratology provides trainees with flexibility to enter scientifi careers in teratology, developmental toxicology, neurobehavioral teratology, developmental biology, or developmental neuroscience with equal facility. This renewal continues the strengths of the program from the past and adds new faculty and resources to move teratology training to the next level of understanding the prenatal origins of disorders and diseases.