Training Grant in Teratology

畸胎学培训补助金

• 批准号: 7658142
• 负责人: Charles V Vorhees
• 金额: $ 24.71万
• 依托单位: CINCINNATI CHILDRENS HOSP MED CTR
• 依托单位国家: 美国
• 财政年份: 1977
• 资助国家: 美国
• 起止时间: 1977-07-01 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7658142
• 关键词: Grant; Teratology; Training

DESCRIPTION (provided by applicant) The goal of this doctoral and postdoctoral training program is to educate scientists who will provide fundamental insights into the causes and prevention of birth defects and functional abnormalities of prenatal origin. Predoctorates are selected from among interested Molecular and Developmental Biology (MDB) Program graduate students who all take classes in developmental biology, molecular genetics, cell biology and biochemistry as their core curriculum; teratology students take these classes and courses in teratology, biostatistics (new requirement), and toxicology (optional). Neuroteratology students take the aforementioned courses and courses in neuroscience. Postdoctorates also take the teratology course and all pre- and postdoctorates take an ethics in research course. Postdoctorates enter the training program through the Cincinnati Children's Research Foundation (CCRF) Office of Postdoctoral Affairs (new). All of the training faculty operate active, extramurally funded laboratories and all have experience training graduate students and postdoctorates. As a result, trainees show high research productivity, attend national meetings, and secure good positions upon completion. A high percentage of past trainees remain in science, most in teratology, thereby helping to fill the national need for scientists in this specialty. Accordingly, four predoctoral and three postdoctoral positions are requested (as before). During the current funding period, the program had its first URM trainee; in addition, several curriculum changes have been made that strengthen training in developmental genetics, and a new research building and new core facilities are being built that will add to the current research environment. Faculty membership continues to evolve with new faculty added during this period and faculty research shifting toward more investigations involving environmental agents and their effects on development. This program fills a unique niche as the only NIEHS training grant dedicated to training in teratology. This is important because teratology is not a field with its own academic home because it spans disciplines ranging from developmental biology to genetics, and toxicology to neurobiology. This renewal represents a continuation of the strengths of the program from the past and adds new initiatives that will move teratology training to the next level in understanding the mechanisms of abnormal development. BACKGROUND This NIEHS training program was established in 1977. Since the last competing renewal several mentors resigned from the program due to retirement, or because they are no longer accepting trainees or they are shifting focus away from areas directly relevant to the NIEHS mission. Conversely, the training program added five new faculty members (Drs. Campbell, Karp, Kuan, Wells, and Williams) who have research programs relevant to the training program. The training program has also retained seven continuing faculty members (Drs. Daston, Ma, Nebert, Potter, Scott, Vorhees, and Yutzey) from the previous funding cycle. Several curriculum changes have been made that have strengthen the training in developmental genetics, and a new research building and new Core facilities are being built that will add to the current research environment. This application represents a continuation of the strengths of the program from the past and adds new initiatives that will move teratology training to the next level in understanding the mechanisms of abnormal development

描述(由申请人提供) 这一博士和博士后培训计划的目标是教育科学家，他们将对出生缺陷和产前起源的功能异常的原因和预防提供基本的见解。博士预科生是从对分子与发育生物学(MDB)项目感兴趣的研究生中挑选出来的，他们都将发育生物学、分子遗传学、细胞生物学和生物化学作为其核心课程；畸形学学生将这些课程和课程选在畸胎学、生物统计学(新要求)和毒理学(选修课)。神经畸形学专业的学生选修上述课程和神经科学课程。博士后也选修畸形学课程，所有博士后和博士后都选修研究课程中的伦理学。博士后通过辛辛那提儿童研究基金会(CCRF)博士后事务办公室(NEW)进入培训计划。所有培训教师都运营着活跃的、由校外资助的实验室，他们都有培训研究生和博士后的经验。因此，学员表现出很高的研究效率，参加国家会议，并在完成工作后获得良好的职位。过去的受训人员中有很高比例留在了科学领域，其中大部分是畸形学，从而帮助填补了国家对该专业科学家的需求。因此，需要4个博士后和3个博士后职位(同以前一样)。在目前的资助期间，该方案有了第一名URM学员；此外，还进行了几次课程改革，以加强发展遗传学方面的培训，并正在建造一座新的研究大楼和新的核心设施，这将增加目前的研究环境。在此期间，随着新的教员的增加，教员人数继续发展，教员研究转向更多涉及环境因素及其对发展影响的调查。这一计划填补了一个独特的利基作为唯一的NIEHS培训赠款致力于培训的畸形学。这一点很重要，因为畸形学不是一个有自己的学术家园的领域，因为它跨越了从发育生物学到遗传学，从毒理学到神经生物学的多个学科。这一更新代表了该计划过去的优势的延续，并增加了新的倡议，将把畸形学培训推向理解异常发育机制的下一个水平。 背景 这项NIEHS培训计划成立于1977年。自上一次竞争性续签以来，有几名导师因退休、不再接受学员或将重点从与NIEHS使命直接相关的领域转移而退出了该项目。相反，培训计划增加了五名新的教员(Campbell、Karp、Kuan、Wells和Williams博士)，他们拥有与培训计划相关的研究计划。该培训计划还保留了前一个资助周期的七名继续教员(Daston博士、Ma博士、Nebert博士、Potter博士、Scott博士、Vorhees博士和Yutzey博士)。已经进行了几次课程改革，加强了发展遗传学的培训，正在建造一座新的研究大楼和新的核心设施，这将增加目前的研究环境。该应用程序延续了该计划过去的优势，并增加了新的举措，将畸形学培训推向新的水平，以了解异常发育的机制。