UCLA SPORE in Prostate Cancer

UCLA SPORE 在前列腺癌中的应用

• 批准号: 8548477
• 负责人: ROBERT E REITER
• 金额: $ 215.05万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-15 至 2018-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8548477
• 关键词: Anatomy; Androgen Receptor; Area; Attention; Bioinformatics; Biological Markers; Biometry; Cancer Patient; Castration; Cell Nucleus; Chemistry; Clinic; Clinical; Development; Diagnosis; Diet Modification; Discipline; Disease; Engineering; Environment; FDA approved; Faculty; Fat-Restricted Diet; Fostering; Funding; Goals; Human; Image; Institutes; Institution; Interdisciplinary Study; Laboratory Research; Malignant neoplasm of pancreas; Malignant neoplasm of prostate; Measurable; Molecular; Morbidity - disease rate; Nanotechnology; National Cancer Institute; Neoplasm Circulating Cells; Neoplasm Metastasis; Omega-3 Fatty Acids; Outcome; PTEN gene; Pathology; Pathway interactions; Primary Prevention; Prostate; Radiology Specialty; Research; Research Infrastructure; Research Personnel; Research Support; Resistance; Scientist; Secondary Prevention; Seminal; Services; Signal Pathway; Signal Transduction; Sister; Solutions; Specimen; Staging; Talents; Technology; Translational Research; Translations; antibody engineering; anticancer research; base; cancer cell; cancer stem cell; career development; clinical application; clinical practice; data management; design; dietary supplements; human capital; improved; innovation; men; mortality; nanosystems; new technology; novel; outcome forecast; pre-clinical; prevent; programs; prostate stem cell antigen; stem cell biology; tumor microenvironment

The UCLA Prostate Cancer SPORE is a multidisciplinary and translational research program focused on the development of new and innovative approaches for improving the diagnosis, prognosis, and treatment of prostate cancer patients. Initially built around a small nucleus of basic and clinical scientists, the program has expanded around campus to bring diverse talents from disciplines as varied as Chemistry, Nanotechnology, Stem Cell Biology, Pathology and Radiology to focus on the prostate cancer problem. This campus-wide (including UCLA affiliated-institutions) enterprise has led to significant discoveries with potential major impact on men with prostate cancer. The overall goal of this competitive renewal application is to continue to apply the diversity of talent on the UCLA campus and its sister institutions to the critical and evolving translational challenges in the fied of prostate cancer. To achieve the long-term objectives and goals of our program, the Specific Aims of the UCLA SPORE in Prostate Cancer are: 1. Perform high-impact translational research focused on some of the major challenges in the field of prostate cancer by: 2. Provide organizational infrastructure and novel technologies designed specifically to support the translational research objectives of the SPORE: 3. Develop new prostate cancer researchers and research areas to advance translational research in prostate cancer

加州大学洛杉矶分校前列腺癌孢子是一个多学科和转化性研究计划，专注于开发新的和创新的方法来改善前列腺癌患者的诊断、预后和治疗。该项目最初是围绕基础和临床科学家的小圈子建立的，后来在校园内扩大，吸引了来自化学、纳米技术、干细胞生物学、病理学和放射学等不同学科的不同人才，专注于前列腺癌问题。这一校园范围(包括加州大学洛杉矶分校附属机构)的企业带来了重大发现，对患有前列腺癌的男性具有潜在的重大影响。此次竞争性续签申请的总体目标是继续将多样化的人才应用于加州大学洛杉矶分校 校园及其姊妹机构应对前列腺癌领域的关键和不断变化的翻译挑战。为了实现我们项目的长期目标和目标，加州大学洛杉矶分校前列腺癌分生孢子的具体目标是： 1.通过以下方式对前列腺癌领域的一些主要挑战进行高影响力的转化性研究： 2.提供专门为支持孢子翻译研究目标而设计的组织基础设施和新技术： 3.开发新的前列腺癌研究人员和研究领域，以推进前列腺癌的翻译研究