Development of optimal sodium-MRI methodology for the musculoskeletal field.

开发肌肉骨骼领域的最佳钠 MRI 方法。

• 批准号: 8490316
• 负责人: Jae-Seung Lee
• 金额: $ 9.62万
• 依托单位: NEW YORK UNIVERSITY SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-07-18 至 2016-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8490316
• 关键词: Accounting; Area; Biological Markers; Biological Models; Biology; Biomechanics; Biometry; Brain; Brain Neoplasms; Breast; Cartilage; Chemistry; Clinical; Clinical Protocols; Clinical Research; Clinical Trials Design; Coupling; Degenerative polyarthritis; Detection; Development; Diagnosis; Diagnostic; Disease; Doctor of Philosophy; Environment; Equipment; Glycosaminoglycans; Goals; Group Meetings; Image; Immune; International; Intervertebral disc structure; Joints; Journals; Kidney; Learning; MRI Scans; Magnetic Resonance Imaging; Measurement; Measures; Medical; Medical Imaging; Medical center; Medicine; Mentors; Methodology; Methods; Monitor; Musculoskeletal; Musculoskeletal Diseases; NMR Spectroscopy; New York; Onset of illness; Organ; Osteoarthrosis Deformans; Performance; Physics; Play; Preparation; Protocols documentation; Radiology Specialty; Relaxation; Research; Research Personnel; Research Training; Sampling; Scanning; Scheme; Science; Scientist; Signal Transduction; Sodium; Synovial Fluid; System; Techniques; Technology; Testing; Time; Tissues; Training; Training Programs; Translating; Universities; Variant; Walkers; Work; articular cartilage; base; career; clinical Diagnosis; clinical application; clinical practice; design; effusion; image reconstruction; improved; in vivo; interest; intervertebral disk degeneration; magnetic field; malignant breast neoplasm; novel; optimal control theory; reconstruction; research and development; responsible research conduct; skills; symposium; tissue phantom; tool; volunteer

DESCRIPTION (provided by applicant): Jae-Seung Lee, PhD has a strong background in experimental physics and NMR spectroscopy, and his overarching career goal is to become an independent academic research scientist working at the interface between Physics, Chemistry, and Medicine in the area of MRI diagnostics. To achieve this long-term goal, Dr. Lee plans to extend his research area into the medical sciences through a plan for acquiring clinical medical imaging and radiology expertise, as well as, learning essential skills of the preparation of clinical studies. Dr. Lee is currently a postdoctoral researcher at the Radiology Department at New York University Langone Medical Center. Under the guidance of the mentoring team (mentor: Dr. Sodickson, co-mentors: Dr. Regatte, Dr. Jerschow, Dr. Thorsten Kirsch, Dr. Peter Walker, Dr. Steven Abramson, collaborator: Dr. Recht) , Dr. Lee will enter a rigorous training program consisting of (1) hands-on research training in advanced MRI technologies, (2) formal didactic training via graduate courses in advanced Magnetic Resonance Imaging, Cartilage Biology, Medicine, Biomechanics, Biostatistics, and Clinical Trials Design, (3) contribution to journal clubs and group meetings in the research groups of the mentor and co-mentors, (4) participation in national and international conferences and symposia, and (5) participation in training courses in the responsible conduct of research. The proposed research is devoted to the development of sodium MRI contrast techniques by applying optimal control theory, dedicated to the diagnosis of important diseases related to musculoskeletal disorders. These diseases can be monitored by measuring the amount of sodium in tissues, since it relates to the concentration of glycosaminoglycans in cartilage and the intervertebral disc. These concentrations, in turn, are important indicators for the onset of disorders. Using optimal control theory, Dr. Lee plans to design optimal RF excitation schemes for creating new sodium contrast in tissues. In addition, optimal detection schemes will be designed for faster scan times, and finally, to translate the developed methods to clinical practice, thereby making sodium MRI a readily available diagnostic tool.

简介(申请人提供)：Jae-seung Lee博士在实验物理和核磁共振光谱学方面拥有深厚的背景，他的首要职业目标是成为一名独立的学术研究科学家，在核磁共振诊断领域从事物理学、化学和医学之间的工作。为了实现这一长期目标，李博士计划通过一项获取临床医学成像和放射学专业知识的计划，以及学习准备临床研究的基本技能，将他的研究范围扩展到医学科学。李博士目前是纽约大学朗格尼医学中心放射科的博士后研究员。在导师团队(导师：索迪克森博士，共同导师：雷加特博士、杰斯鲁博士、托尔斯滕·基尔希博士、彼得·沃克博士、史蒂文·艾布拉姆森博士、合作者：雷赫特博士)的指导下，李博士将参加一项严格的培训计划，包括(1)先进核磁共振技术的实践研究培训，(2)通过高级磁共振成像、软骨生物学、医学、生物力学、生物统计学和临床试验设计的研究生课程进行正式教学培训，(3)在导师和共同导师的研究小组中为期刊俱乐部和小组会议做出贡献，(4)参加国家和国际会议和专题讨论会，以及(5)参加负责任地开展研究的培训课程。这项拟议的研究致力于应用最优控制理论开发钠核磁共振成像对比剂技术，致力于与肌肉骨骼疾病相关的重要疾病的诊断。这些疾病可以通过测量组织中钠的含量来监测，因为它与软骨和椎间盘中糖胺聚糖的浓度有关。这些浓度反过来又是疾病发病的重要指标。利用最优控制理论，Lee博士计划设计最佳的射频激发方案，以在组织中产生新的钠对比度。此外，将为更快的扫描时间设计最优的检测方案，并最终将开发的方法转化为临床实践，从而使钠核磁共振成为一种容易获得的诊断工具。