开发肌肉骨骼领域的最佳钠 MRI 方法。-猫眼课题宝

开发肌肉骨骼领域的最佳钠 MRI 方法。

批准号：

8874112

负责人：

Jae-Seung Lee

金额：

$9.62万

依托单位：

NEW YORK UNIVERSITY SCHOOL OF MEDICINE

依托单位国家：

美国

项目类别：

财政年份：

2011

资助国家：

美国

项目状态：

已结题

起止时间：

2011-07-18 至 2017-06-30

来源：

https://reporter.nih.gov/project-details/8874112

关键词：

Accounting Area Biological Markers Biological Models Biology Biomechanics Biometry Brain Brain Neoplasms Breast Cartilage Chemistry Clinical Clinical Protocols Clinical Research Clinical Trials Design Coupling Degenerative polyarthritis Detection Development Diagnosis Diagnostic Disease Doctor of Philosophy Environment Equipment Glycosaminoglycans Goals Group Meetings Image Immune International Intervertebral disc structure Joints Journals Kidney Learning MRI Scans Magnetic Resonance Imaging Measurement Measures Medical Medical Imaging Medical center Medicine Mentors Methodology Methods Monitor Musculoskeletal Musculoskeletal Diseases NMR Spectroscopy New York Onset of illness Organ Performance Physics Play Preparation Protocols documentation Radiology Specialty Relaxation Research Research Personnel Research Training Sampling Scanning Scheme Science Scientist Signal Transduction Sodium Synovial Fluid System Techniques Technology Testing Time Tissues Training Training Programs Translating Universities Variant Walkers Work articular cartilage base career clinical Diagnosis clinical application clinical practice design effusion image reconstruction improved in vivo interest intervertebral disk degeneration magnetic field malignant breast neoplasm novel optimal control theory reconstruction research and development responsible research conduct skills symposium tissue phantom tool volunteer

项目摘要

项目成果

Jae-Seung Lee的其他基金

相似基金

相关文献

中文摘要

翻译

点击翻译按钮获取中文摘要

英文摘要

DESCRIPTION (provided by applicant): Jae-Seung Lee, PhD has a strong background in experimental physics and NMR spectroscopy, and his overarching career goal is to become an independent academic research scientist working at the interface between Physics, Chemistry, and Medicine in the area of MRI diagnostics. To achieve this long-term goal, Dr. Lee plans to extend his research area into the medical sciences through a plan for acquiring clinical medical imaging and radiology expertise, as well as, learning essential skills of the preparation of clinical studies. Dr. Lee is currently a postdoctoral researcher at the Radiology Department at New York University Langone Medical Center. Under the guidance of the mentoring team (mentor: Dr. Sodickson, co-mentors: Dr. Regatte, Dr. Jerschow, Dr. Thorsten Kirsch, Dr. Peter Walker, Dr. Steven Abramson, collaborator: Dr. Recht) , Dr. Lee will enter a rigorous training program consisting of (1) hands-on research training in advanced MRI technologies, (2) formal didactic training via graduate courses in advanced Magnetic Resonance Imaging, Cartilage Biology, Medicine, Biomechanics, Biostatistics, and Clinical Trials Design, (3) contribution to journal clubs and group meetings in the research groups of the mentor and co-mentors, (4) participation in national and international conferences and symposia, and (5) participation in training courses in the responsible conduct of research. The proposed research is devoted to the development of sodium MRI contrast techniques by applying optimal control theory, dedicated to the diagnosis of important diseases related to musculoskeletal disorders. These diseases can be monitored by measuring the amount of sodium in tissues, since it relates to the concentration of glycosaminoglycans in cartilage and the intervertebral disc. These concentrations, in turn, are important indicators for the onset of disorders. Using optimal control theory, Dr. Lee plans to design optimal RF excitation schemes for creating new sodium contrast in tissues. In addition, optimal detection schemes will be designed for faster scan times, and finally, to translate the developed methods to clinical practice, thereby making sodium MRI a readily available diagnostic tool.

期刊论文(7)

专著(0)

科研奖励(0)

会议论文