Core Center

该应用程序的总体目标是创建一个以表皮生理学和病理生理学为主题的宾夕法尼亚大学皮肤病研究核心中心(SDRC)，以便利用我们在该领域的特殊专业知识，提供计划和服务，使我们资助的研究更有效率，为科学界提供独特的服务，将其他合作者带入皮肤研究领域，并有一个特殊的目标，鼓励年轻科学家和内科科学家从事皮肤生物学和疾病的研究。具体来说，我们的目标是： 1)建立中央核心设施和资助计划，以支持、协调和鼓励在表皮生物学及其与疾病的关系方面的合作研究。行政核心将为发改委的所有方面提供结构和监督。将建立三个科学核心：a)皮肤组织学和特性；b)组织和角质形成细胞采购；c)干细胞和异种移植。这些科学核心将促进我们重点研究领域的成员的研究，并提供在其他地方不易获得的服务。国家发改委将管理一项试点和可行性(P&F)资助计划，以鼓励科学家将他们的专业知识应用于我们的研究重点，并鼓励这一领域的年轻科学家。 2)鼓励科学交流和互动。国家发改委将主办与其科学主题相关的研讨会和外部演讲，并管理宾夕法尼亚大学发改委的年度务虚会。科学核心将提供专业研究技术的教学。国家发改委行政核心将建立和维护电子和纸质通信 3)为青年科学家提供导师，培养内科科学家。国家发改委将通过导师核心为初级科学家提供高级导师。国家发改委将为参加科学和职业发展会议的青年科学家提供旅行奖励。最后，通过在我们的P&F项目中提供创新的“培训微型移民的医生科学家”，我们将鼓励医生科学家的发展。 总体而言，这项提议的目的是提高人们对皮肤研究的兴趣和合作科学，并帮助为这一领域的未来科学家提供支持。

The overall goal of this application is to create a Penn Skin Diseases Research Core Center (SDRC) with a theme of Physiology and Pathophysiology of Epidermis in order to capitalize on our special expertise in this area to offer programs and services that will make our funded research more efficient, offer unique services to the scientific community to bring other collaborators into the skin research field, and have a special goal of encouraging young scientists, and physician scientists, to pursue research in skin biology and disease. Specifically, our aims are: 1) To establish central core facilities and a funding program to support, coordinate and encourage collaborative research in the area of epidermal biology and its relation to disease. An Administrative Core will provide structure and oversight of all aspects of the SDRC. Three scientific cores will be established: a) Skin Histology and Characterization; b) Tissue and Keratinocyte Procurement; c) Stem Cell and Xenograft. These scientific cores will facilitate research of members in our focused research area with services not easily available elsewhere. The SDRC will manage a Pilot & Feasibility (P & F) grant program in order to encourage scientists to bring their expertise to our research focus and to encourage young scientists in this area. 2) To encourage scientific communications and interactions. The SDRC will sponsor seminars and outside speakers related to its scientific theme, and administer a yearly Penn SDRC retreat. The scientific cores will provide teaching of specialized research techniques. The SDRC Administrative Core will establish and maintain electronic and paper communications 3) To provide mentorship for young scientists and to develop physician scientists. The SDRC will provide senior mentors to junior scientists through a Mentoring Core. The SDRC will provide travel awards for young scientists to attend scientific and career development meetings. Finally, by offering innovative "Physician Scientist in Training Minigrants" in our P & F program we will encourage the development of physician scientists. Overall this proposed SDRC aims to increase interest and collaborative science in skin research and to help provide for future scientists in this area.