Core Center

核心中心

• 批准号: 8499260
• 负责人: John R Stanley
• 金额: $ 60.8万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-07-01 至 2014-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8499260
• 关键词: Area; Award; Biology; Communication; Communities; Core Facility; Development; Disease; Educational process of instructing; Electronics; Epidermis; Functional disorder; Funding; Future; Goals; Grant; Health; Histology; Life; Mentors; Mentorship; Paper; Physicians; Physiology; Research; Research Technics; Science; Scientist; Services; Skin; Stem cells; Structure; Tissues; Training; Travel; Xenograft procedure; career development; improved; innovation; interest; keratinocyte; meetings; member; programs; skin disorder

The overall goal of this application is to create a Penn Skin Diseases Research Core Center (SDRC) with a theme of Physiology and Pathophysiology of Epidermis in order to capitalize on our special expertise in this area to offer programs and services that will make our funded research more efficient, offer unique services to the scientific community to bring other collaborators into the skin research field, and have a special goal of encouraging young scientists, and physician scientists, to pursue research in skin biology and disease. Specifically, our aims are: 1) To establish central core facilities and a funding program to support, coordinate and encourage collaborative research in the area of epidermal biology and its relation to disease. An Administrative Core will provide structure and oversight of all aspects of the SDRC. Three scientific cores will be established: a) Skin Histology and Characterization; b) Tissue and Keratinocyte Procurement; c) Stem Cell and Xenograft. These scientific cores will facilitate research of members in our focused research area with services not easily available elsewhere. The SDRC will manage a Pilot & Feasibility (P & F) grant program in order to encourage scientists to bring their expertise to our research focus and to encourage young scientists in this area. 2) To encourage scientific communications and interactions. The SDRC will sponsor seminars and outside speakers related to its scientific theme, and administer a yearly Penn SDRC retreat. The scientific cores will provide teaching of specialized research techniques. The SDRC Administrative Core will establish and maintain electronic and paper communications 3) To provide mentorship for young scientists and to develop physician scientists. The SDRC will provide senior mentors to junior scientists through a Mentoring Core. The SDRC will provide travel awards for young scientists to attend scientific and career development meetings. Finally, by offering innovative "Physician Scientist in Training Minigrants" in our P & F program we will encourage the development of physician scientists. Overall this proposed SDRC aims to increase interest and collaborative science in skin research and to help provide for future scientists in this area.

本申请的总体目标是创建一个以表皮生理学和病理生理学为主题的宾夕法尼亚皮肤病研究核心中心（SDRC），以利用我们在该领域的特殊专业知识提供计划和服务，使我们资助的研究更有效，为科学界提供独特的服务，将其他合作者带入皮肤研究领域，并有一个特别的目标，鼓励年轻的科学家和医生科学家，从事皮肤生物学和疾病的研究。具体而言，我们的目标是： 1)建立中央核心设施和资助计划，以支持，协调和鼓励在表皮生物学及其与疾病的关系领域的合作研究。一个行政核心将为SDRC的所有方面提供结构和监督。将建立三个科学核心：a）皮肤组织学和表征; B）组织和角质细胞获取; c）干细胞和异种移植。这些科学核心将促进成员在我们重点研究领域的研究，并提供其他地方不容易获得的服务。SDRC将管理试点和可行性（P & F）资助计划，以鼓励科学家将他们的专业知识带到我们的研究重点，并鼓励这一领域的年轻科学家。 2)鼓励科学交流和互动。SDRC将赞助与其科学主题相关的研讨会和外部演讲者，并管理每年一次的宾州SDRC务虚会。科学核心将提供专门研究技术的教学。SDRC行政核心将建立和维护电子和纸质通信 3)为青年科学家提供指导，培养医生科学家。SDRC将通过指导核心为初级科学家提供高级导师。SDRC将为年轻科学家提供旅行奖励，以参加科学和职业发展会议。最后，通过在我们的P & F计划中提供创新的“医生科学家培训小移民”，我们将鼓励医生科学家的发展。 总的来说，SDRC的目的是增加对皮肤研究的兴趣和合作科学，并帮助为这一领域的未来科学家提供帮助。

项目成果

Exophiala spinifera as a cause of cutaneous phaeohyphomycosis: case study and review of the literature.

Exophiala spinifera 作为皮肤暗色丝孢菌病的原因：案例研究和文献综述。

• DOI: 10.1080/13693780802412611
• 发表时间: 2009
• 期刊: Medical mycology
• 影响因子: 2.9
• 作者: Harris,JohnE;Sutton,DeannaA;Rubin,Adam;Wickes,Brian;DeHoog,GS;Kovarik,Carrie
• 通讯作者: Kovarik,Carrie

Grabbing amphiregulin by the tail to better understand keratinocyte growth.

抓住双调蛋白的尾巴以更好地了解角质形成细胞的生长。

• DOI: 10.1038/jid.2010.199
• 发表时间: 2010
• 期刊: The Journal of investigative dermatology
• 作者: Seykora,JohnT

Synergy of understanding dermatologic disease and epidermal biology.

了解皮肤病和表皮生物学的协同作用。

• DOI: 10.1172/jci62237
• 发表时间: 2012
• 期刊: The Journal of clinical investigation
• 作者: Stanley,JohnR

Lysosomes Support the Degradation, Signaling, and Mitochondrial Metabolism Necessary for Human Epidermal Differentiation.

• DOI: 10.1016/j.jid.2018.02.035
• 发表时间: 2018-09
• 期刊: The Journal of investigative dermatology
• 作者: Monteleon CL;Agnihotri T;Dahal A;Liu M;Rebecca VW;Beatty GL;Amaravadi RK;Ridky TW
• 通讯作者: Ridky TW

Equestrian perniosis: a report of 2 cases and a review of the literature.

马术冻疮2例报告并文献复习.

• DOI: 10.1097/dad.0b013e31824c221f
• 发表时间: 2013
• 期刊: The American Journal of dermatopathology
• 作者: Stewart,CampbellL;Adler,DonaldJ;Jacobson,Abby;Brod,BruceA;Shinohara,MichiM;Seykora,JohnT;Elenitsas,Rosalie;Rosenbach,Misha
• 通讯作者: Rosenbach,Misha