CTRP Supplement

描述（由申请人提供）：病例综合癌症中心（病例CCC）的使命，现在是NCI指定的第25个年头，是促进应用于人类癌症的科学发现的协调，转化研究为导向的文化，传播给患者和人群，以改善癌症预防，检测，治疗，治愈和生存。该中心领导和监督基础癌症研究的合作，以确定新的治疗靶点;预防，控制和人口研究;整个疾病谱的治疗和非治疗临床研究;和社区外展。该中心协调克利夫兰和北方俄亥俄州癌症研究的各个方面，包括凯斯西储大学医学院附属机构的活动：克利夫兰诊所和大学医院。该中心为该地区每年新诊断的近10，000名癌症患者提供参与临床试验的机会。新的独立癌症医院UH Seidman癌症中心于2011年开业，Gl SPORE的资助代表了过去赠款周期的重大成就。案例CCC围绕8个科学项目，15个共享资源以及临床和行为癌症研究基础设施进行组织，该基础设施优先考虑跨科学项目的创新转化研究和临床发起的临床试验。案例CCC包括来自5所学校和30个学术部门的232名正式成员（共335名成员），他们积极参与癌症中心的活动，包括计划和核心会议和务虚会，领导委员会和科学焦点小组，每个人都促进跨学科的方法，促进发现和临床应用。该中心的癌症重点是特殊的，总资金超过1.16亿美元，总NCI资金超过4500万美元。机构的承诺也是例外，下一个周期将有超过1.15亿美元用于癌症研究，预计将有超过3.5亿美元用于建设。Case CCC及其附属机构建立了出色的基础设施，使其成员能够通过发现，实施和传播来改善癌症的预防，诊断和治疗，同时为癌症患者及其家属提供最先进的护理和治疗。Case CCC是NCI的重要合作伙伴，致力于通过最高质量的发现和临床研究改变癌症护理实践。

DESCRIPTION (provided by applicant): The mission of Case Comprehensive Cancer Center (Case CCC), now in its 25th year of NCI designation, is to promote a coordinated, translational research-oriented culture of scientific discovery applied to human cancers, with dissemination to patients and populations to improve cancer prevention, detection, treatment, cure, and survivorship. The Center provides leadership and oversight of collaboration for basic cancer research oriented toward identification of novel therapeutic targets; prevention, control and population research; therapeutic and non-therapeutic clinical research across the disease spectrum; and community outreach. The Center coordinates all aspects of cancer research in Cleveland and Northern Ohio, including activities of the affiliate institutions of Case Western Reserve University School of Medicine: Cleveland Clinic and University Hospitals. The Center provides opportunities to participate in clinical trials to almost 10,000 cancer patients who are newly diagnosed annually in the region. The opening in 2011 of the new freestanding cancer hospital, UH Seidman Cancer Center, and the funding of the Gl SPORE represent major achievements in this past grant cycle. The Case CCC is organized around 8 Scientific Programs, 15 shared resources, and a clinical and behavioral cancer research infrastructure that prioritizes innovative translational research and investigator-initiated clinical trials that ut across the Scientific Programs. The Case CCC includes 232 full members (335 total members) from 5 schools and 30 academic departments who actively participate in Cancer Center activities including Program and Core meetings and retreats, leadership committees, and scientific focus groups, each promoting a transdisciplinary approach that facilitates discovery and clinical application. The Cancer focus of the Center is exceptional, with over $116M in total funding and over $45M in total NCI funding. Institutional commitment is also exceptional with over $115M dedicated to cancer research in the next cycle and over $350M in construction anticipated. The Case CCC and its affiliate institutions have established an outstanding infrastructure that enables its members to improve the prevention, diagnosis, and treatment of cancer through discovery, implementation and dissemination, while providing state-of-the-art care and treatment to cancer patients and their families. The Case CCC is a significant partner with the NCI in its effort to change the practice of cancer care through discovery and clinical research of the highest quality.