CTRP Supplement

描述（由申请人提供）：Case综合癌症中心（Case CCC）的使命是促进一种协调的，以转化为导向的研究文化，将科学发现应用于人类癌症，并传播给患者和人群，以改善癌症的预防，检测，治疗，治愈和生存。该中心领导和监督以确定新的治疗靶点为导向的基础癌症研究的合作；预防、控制和人口研究；跨疾病谱系的治疗性和非治疗性临床研究；还有社区拓展。该中心协调克利夫兰和俄亥俄州北部癌症研究的各个方面，包括凯斯西储大学医学院附属机构的活动：克利夫兰诊所和大学医院。该中心每年为该地区近1万名新诊断的癌症患者提供参与临床试验的机会。2011年开业的新的独立癌症医院，UH Seidman癌症中心，以及Gl SPORE的资金代表了过去拨款周期的主要成就。Case CCC组织了8个科学项目，15个共享资源，以及一个临床和行为癌症研究基础设施，该基础设施优先考虑跨科学项目的创新转化研究和研究者发起的临床试验。Case CCC包括来自5个学院和30个学术部门的232名正式成员（335名总成员），他们积极参与癌症中心的活动，包括项目和核心会议和务静会，领导委员会和科学焦点小组，每个小组都促进跨学科方法，促进发现和临床应用。该中心对癌症的关注非常突出，总资金超过1.16亿美元，NCI总资金超过4500万美元。机构承诺也非常出色，下一个周期将有超过1.15亿美元用于癌症研究，预计将有超过3.5亿美元用于建设。凯斯癌症中心及其附属机构已经建立了一个卓越的基础设施，使其成员能够通过发现、实施和传播来改善癌症的预防、诊断和治疗，同时为癌症患者及其家属提供最先进的护理和治疗。Case CCC是NCI的重要合作伙伴，致力于通过最高质量的发现和临床研究来改变癌症治疗的实践。

DESCRIPTION (provided by applicant): The mission of Case Comprehensive Cancer Center (Case CCC), now in its 25th year of NCI designation, is to promote a coordinated, translational research-oriented culture of scientific discovery applied to human cancers, with dissemination to patients and populations to improve cancer prevention, detection, treatment, cure, and survivorship. The Center provides leadership and oversight of collaboration for basic cancer research oriented toward identification of novel therapeutic targets; prevention, control and population research; therapeutic and non-therapeutic clinical research across the disease spectrum; and community outreach. The Center coordinates all aspects of cancer research in Cleveland and Northern Ohio, including activities of the affiliate institutions of Case Western Reserve University School of Medicine: Cleveland Clinic and University Hospitals. The Center provides opportunities to participate in clinical trials to almost 10,000 cancer patients who are newly diagnosed annually in the region. The opening in 2011 of the new freestanding cancer hospital, UH Seidman Cancer Center, and the funding of the Gl SPORE represent major achievements in this past grant cycle. The Case CCC is organized around 8 Scientific Programs, 15 shared resources, and a clinical and behavioral cancer research infrastructure that prioritizes innovative translational research and investigator-initiated clinical trials that ut across the Scientific Programs. The Case CCC includes 232 full members (335 total members) from 5 schools and 30 academic departments who actively participate in Cancer Center activities including Program and Core meetings and retreats, leadership committees, and scientific focus groups, each promoting a transdisciplinary approach that facilitates discovery and clinical application. The Cancer focus of the Center is exceptional, with over $116M in total funding and over $45M in total NCI funding. Institutional commitment is also exceptional with over $115M dedicated to cancer research in the next cycle and over $350M in construction anticipated. The Case CCC and its affiliate institutions have established an outstanding infrastructure that enables its members to improve the prevention, diagnosis, and treatment of cancer through discovery, implementation and dissemination, while providing state-of-the-art care and treatment to cancer patients and their families. The Case CCC is a significant partner with the NCI in its effort to change the practice of cancer care through discovery and clinical research of the highest quality.