Case Comprehensive Cancer Center Support Grant

简介（由申请人提供）：Case综合癌症中心（Case CCC）现已成立17年，为基础癌症研究、治疗性和非治疗性癌症临床试验、预防、控制和人口研究提供领导和监督，并为凯斯西储大学的主要附属机构：Case医学院、克利夫兰大学医院和克利夫兰诊所提供社区服务。癌症中心位于克利夫兰，为俄亥俄州北部的380万人提供服务，其成员每年管理超过7,000例新病例，临床试验获得率和应计率高，在单一的方案开发和审查系统，数据安全管理计划和协调的临床试验操作下运作。自上次竞争性续期申请以来，该中心已将NCI的资金增加了53%以上，其同行评审资金总额增加了一倍多。2005年，该中心还累计进行了877例治疗性临床试验。对中心发展资源、教师招聘、共享资源和空间的重大机构承诺，确保了中心的持续成功及其在多学科癌症研究和治疗方面的动态方法。

DESCRIPTION (provided by applicant): The Case Comprehensive Cancer Center (Case CCC), now in its 17 year, provides leadership and oversight for basic cancer research, therapeutic and non-therapeutic cancer clinical trials, prevention, control and population research, as well as community outreach for the major affiliate institutions of Case Western Reserve University: Case School of Medicine, University Hospitals of Cleveland, and the Cleveland Clinic. Located in Cleveland and serving the 3.8 million people in Northern Ohio, members of the Cancer Center manage over 7,000 new cases per year with a high rate of clinical trial access and accrual, operating under a single protocol development and review system, data safety management plan, and a coordinated clinical trials operation. Since the last competitive renewal application, the Center has increased NCI funding by more than 53%, and more than doubled its total peer-reviewed funding. The Center also accrued 877 patients to therapeutic clinical trials in 2005. Significant institutional commitment to Center development resources, faculty recruitment, shared resources, and space assures the Center's continued success and its dynamic approach to multidisciplinary cancer research and therapeutics. The Case CCC has 9 Scientific Programs, 17 shared resources including 6 that are new, and a clinical and behavioral cancer research infrastructure that prioritizes innovative translational research and investigator-initiated clinical trials that cut across the Scientific Programs. These programs include Cancer Genetics, Cell Proliferation and Cell Death, Radiation and Cellular Stress Response, Molecular Mechanisms of Oncogenesis, GU Malignancies (new), Stem Cells and Hematologic Malignancies, Developmental Therapeutics, Cancer Prevention, Control and Population Research, and Aging-Cancer Research (new). The new Shared Resources include Imaging Research, Proteomics, Hybridoma, Transgenic & Targeting, Translational Research, and Practice-Based Research Network. Each of these new Shared Resources is fully operational, supporting the cancer research of multiple members across programs, and providing a critical platform for multidisciplinary and interdisciplinary research. This scientific organization and infrastructure furthers the mission of the Case CCC: to improve the prevention, diagnosis, and therapy of cancer through discovery, evaluation, and dissemination that together reduce cancer morbidity and mortality in Northern Ohio and the Nation.