Case Comprehensive Cancer Center Support Grant

描述（申请人提供）：凯斯综合癌症中心（案例CCC），现在在其17年，为基础癌症研究，治疗和非治疗性癌症临床试验，预防，控制和人口研究，以及凯斯西储大学的主要附属机构的社区外展提供领导和监督：凯斯医学院、克利夫兰大学医院和克利夫兰诊所。癌症中心位于克利夫兰，为北方俄亥俄州的380万人提供服务，癌症中心的成员每年管理7，000多例新病例，临床试验访问和累积率很高，在单一的方案开发和审查系统、数据安全管理计划和协调的临床试验操作下运行。自上次竞争性更新申请以来，该中心已将NCI资金增加了53%以上，并将其同行评审资金总额增加了一倍多。2005年，该中心还为877名患者进行了治疗性临床试验。对中心发展资源，教师招聘，共享资源和空间的重大机构承诺确保了中心的持续成功及其对多学科癌症研究和治疗的动态方法。 案例CCC有9个科学项目，17个共享资源，包括6个新的，以及一个临床和行为癌症研究基础设施，优先考虑创新的转化研究和跨科学项目的临床试验。这些计划包括癌症遗传学，细胞增殖和细胞死亡，辐射和细胞应激反应，肿瘤发生的分子机制，GU肿瘤（新），干细胞和血液肿瘤，发育治疗学，癌症预防，控制和人口研究，以及衰老癌症研究（新）。新的共享资源包括成像研究，蛋白质组学，杂交，转基因和靶向，转化研究和基于实践的研究网络。这些新的共享资源中的每一个都是全面运作的，支持跨项目的多个成员的癌症研究，并为多学科和跨学科研究提供了一个重要的平台。这一科学组织和基础设施进一步推动了案例CCC的使命：通过发现、评估和传播来改善癌症的预防、诊断和治疗，共同降低北方俄亥俄州和全国的癌症发病率和死亡率。

DESCRIPTION (provided by applicant): The Case Comprehensive Cancer Center (Case CCC), now in its 17 year, provides leadership and oversight for basic cancer research, therapeutic and non-therapeutic cancer clinical trials, prevention, control and population research, as well as community outreach for the major affiliate institutions of Case Western Reserve University: Case School of Medicine, University Hospitals of Cleveland, and the Cleveland Clinic. Located in Cleveland and serving the 3.8 million people in Northern Ohio, members of the Cancer Center manage over 7,000 new cases per year with a high rate of clinical trial access and accrual, operating under a single protocol development and review system, data safety management plan, and a coordinated clinical trials operation. Since the last competitive renewal application, the Center has increased NCI funding by more than 53%, and more than doubled its total peer-reviewed funding. The Center also accrued 877 patients to therapeutic clinical trials in 2005. Significant institutional commitment to Center development resources, faculty recruitment, shared resources, and space assures the Center's continued success and its dynamic approach to multidisciplinary cancer research and therapeutics. The Case CCC has 9 Scientific Programs, 17 shared resources including 6 that are new, and a clinical and behavioral cancer research infrastructure that prioritizes innovative translational research and investigator-initiated clinical trials that cut across the Scientific Programs. These programs include Cancer Genetics, Cell Proliferation and Cell Death, Radiation and Cellular Stress Response, Molecular Mechanisms of Oncogenesis, GU Malignancies (new), Stem Cells and Hematologic Malignancies, Developmental Therapeutics, Cancer Prevention, Control and Population Research, and Aging-Cancer Research (new). The new Shared Resources include Imaging Research, Proteomics, Hybridoma, Transgenic & Targeting, Translational Research, and Practice-Based Research Network. Each of these new Shared Resources is fully operational, supporting the cancer research of multiple members across programs, and providing a critical platform for multidisciplinary and interdisciplinary research. This scientific organization and infrastructure furthers the mission of the Case CCC: to improve the prevention, diagnosis, and therapy of cancer through discovery, evaluation, and dissemination that together reduce cancer morbidity and mortality in Northern Ohio and the Nation.