Case Comprehensive Cancer Center Support Grant

描述(申请人提供)：凯斯综合癌症中心(CASE CCC)，现已成立17年，为基础癌症研究、治疗性和非治疗性癌症临床试验、预防、控制和人口研究提供领导和监督，并为凯斯西储大学的主要附属机构：凯斯西储大学医学院、克利夫兰大学医院和克利夫兰诊所提供社区外联服务。癌症中心的成员位于克利夫兰，为北俄亥俄州的380万人提供服务，每年管理超过7000个新病例，具有较高的临床试验获得率和应收率，在单一的方案制定和审查系统、数据安全管理计划和协调的临床试验操作下运作。自上次竞争性续签申请以来，该中心已将NCI资金增加了53%以上，并将其同行审查资金总额增加了一倍以上。2005年，该中心还招募了877名患者参加治疗临床试验。机构对中心发展资源、教师招聘、共享资源和空间的重大承诺确保了中心的持续成功及其在多学科癌症研究和治疗方面的动态方法。 Case CCC有9个科学计划，17个共享资源，其中包括6个新资源，以及一个临床和行为癌症研究基础设施，该基础设施优先考虑创新的转化性研究和研究人员发起的临床试验，这些研究跨越了科学计划。这些项目包括癌症遗传学、细胞增殖和细胞死亡、辐射和细胞应激反应、肿瘤发生的分子机制、GU恶性肿瘤(NEW)、干细胞和血液恶性肿瘤、发展治疗学、癌症预防、控制和人口研究以及衰老-癌症研究(NEW)。新的共享资源包括影像研究、蛋白质组学、杂交瘤、转基因和靶向、翻译研究和基于实践的研究网络。这些新的共享资源中的每一个都是完全可操作的，支持跨计划的多个成员的癌症研究，并为多学科和跨学科研究提供关键平台。这一科学组织和基础设施进一步推动了CASE CCC的使命：通过发现、评估和传播来改进癌症的预防、诊断和治疗，共同降低俄亥俄州北部和全国的癌症发病率和死亡率。

DESCRIPTION (provided by applicant): The Case Comprehensive Cancer Center (Case CCC), now in its 17 year, provides leadership and oversight for basic cancer research, therapeutic and non-therapeutic cancer clinical trials, prevention, control and population research, as well as community outreach for the major affiliate institutions of Case Western Reserve University: Case School of Medicine, University Hospitals of Cleveland, and the Cleveland Clinic. Located in Cleveland and serving the 3.8 million people in Northern Ohio, members of the Cancer Center manage over 7,000 new cases per year with a high rate of clinical trial access and accrual, operating under a single protocol development and review system, data safety management plan, and a coordinated clinical trials operation. Since the last competitive renewal application, the Center has increased NCI funding by more than 53%, and more than doubled its total peer-reviewed funding. The Center also accrued 877 patients to therapeutic clinical trials in 2005. Significant institutional commitment to Center development resources, faculty recruitment, shared resources, and space assures the Center's continued success and its dynamic approach to multidisciplinary cancer research and therapeutics. The Case CCC has 9 Scientific Programs, 17 shared resources including 6 that are new, and a clinical and behavioral cancer research infrastructure that prioritizes innovative translational research and investigator-initiated clinical trials that cut across the Scientific Programs. These programs include Cancer Genetics, Cell Proliferation and Cell Death, Radiation and Cellular Stress Response, Molecular Mechanisms of Oncogenesis, GU Malignancies (new), Stem Cells and Hematologic Malignancies, Developmental Therapeutics, Cancer Prevention, Control and Population Research, and Aging-Cancer Research (new). The new Shared Resources include Imaging Research, Proteomics, Hybridoma, Transgenic & Targeting, Translational Research, and Practice-Based Research Network. Each of these new Shared Resources is fully operational, supporting the cancer research of multiple members across programs, and providing a critical platform for multidisciplinary and interdisciplinary research. This scientific organization and infrastructure furthers the mission of the Case CCC: to improve the prevention, diagnosis, and therapy of cancer through discovery, evaluation, and dissemination that together reduce cancer morbidity and mortality in Northern Ohio and the Nation.