Molecular determinants of lung cancer in HIV infected and uninfected individuals in Uganda and Tanzania
乌干达和坦桑尼亚艾滋病毒感染者和未感染者肺癌的分子决定因素
基本信息
- 批准号:10267199
- 负责人:
- 金额:$ 31.24万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-09-21 至 2025-08-31
- 项目状态:未结题
- 来源:
- 关键词:AccelerationAddressAdenocarcinomaAfricaAfrica South of the SaharaAfricanAgeAgingBiological MarkersBlood CellsCD4 Positive T LymphocytesCancer PatientCell CountCountryDNADNA MethylationDataDevelopmentDiagnosisDiseaseDisease OutcomeDisease ProgressionEastern Cooperative Oncology GroupEnvironmental Risk FactorEpidemiologic FactorsEpidemiologyEquipmentFutureGenomicsGenotypeHIVHIV InfectionsHIV-1HistologyHomeImageImmuneImmunosuppressionIncidenceIndividualIndoor Air PollutionInfectionInstitutesInternationalLinkLung CapacityMalignant NeoplasmsMalignant neoplasm of lungMeasuresMedical centerMethylationMolecularMolecular ProfilingMultivariate AnalysisMutationMutation AnalysisPathologicPatientsPerformance StatusPersonsPoliciesPremature aging syndromePsychological TransferRelative RisksReportingRiskRisk FactorsRoleSamplingSmokerSmokingSomatic MutationSouth AfricaSquamous cell carcinomaTanzaniaTechnologyTobacco smoking behaviorTransferenceTuberculosisTyrosine Kinase InhibitorUgandaUniversity HospitalsViral Load resultVirus DiseasesWorld Health Organizationadvanced diseaseantiretroviral therapybasecancer riskcohortcookingenvironmental tobacco smokemethylation patternmethylomeprospectivescreeningstandard of caretherapeutically effective
项目摘要
ABSTRACT – Project 2
We will assess molecular risks and co-incidence of lung cancer, HIV and accelerated aging as a factor in lung
cancer incidence and progression in HIV infected patients. We will define the somatic mutations of lung cancer,
link them to HIV subtype and explore the hypothesized role of DNA methylome aging in HIV- infected versus
uninfected individuals as an associative factor that could potentially be utilized as a future biomarker to predict
likelihood of lung cancer development or disease progression. These data will provide the first comprehensive
assessment of somatic mutation burden in East African lung cancer, which will guide access to therapeutically
effective agents to target actionable lung cancer mutations. These will be linked to risk factors associated with
HIV including immunosuppression, immune protection, and accelerated aging that may increase the risk of
cancer in HIV+ individuals. These will help to discern whether epidemiological factors from Project 1 can project
risk for lung cancer at the molecular level and whether, together, we can identify prominent factors linking
epidemiologic risk, HIV-1 infection, and lung cancer in East Africa.
摘要-项目2
我们将评估分子风险和肺癌,艾滋病毒和加速老化的共同发病率作为一个因素在肺
HIV感染患者的癌症发病率和进展。我们将定义肺癌的体细胞突变,
将它们与HIV亚型联系起来,并探索DNA甲基化组老化在HIV感染者与
未感染的个体作为一个关联因素,可能被用作未来的生物标志物,以预测
肺癌发展或疾病进展的可能性。这些数据将提供第一个全面的
评估东非肺癌的体细胞突变负担,这将指导获得治疗
靶向可操作的肺癌突变的有效药剂。这些将与与以下相关的风险因素相关联:
艾滋病毒包括免疫抑制,免疫保护和加速老化,可能会增加风险,
HIV+患者的癌症。这些将有助于辨别项目1中的流行病学因素是否可以预测
在分子水平上的肺癌风险,以及我们是否可以共同确定
流行病学风险、HIV-1感染和东非肺癌。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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STANTON L. GERSON其他文献
STANTON L. GERSON的其他文献
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{{ truncateString('STANTON L. GERSON', 18)}}的其他基金
Molecular determinants of lung cancer in HIV infected and uninfected individuals in Uganda and Tanzania
乌干达和坦桑尼亚艾滋病毒感染者和未感染者肺癌的分子决定因素
- 批准号:
10084628 - 财政年份:2020
- 资助金额:
$ 31.24万 - 项目类别:
Molecular determinants of lung cancer in HIV infected and uninfected individuals in Uganda and Tanzania
乌干达和坦桑尼亚艾滋病毒感染者和未感染者肺癌的分子决定因素
- 批准号:
10478912 - 财政年份:2020
- 资助金额:
$ 31.24万 - 项目类别:
Lung cancer in East Africa and the relationship to HIV-1 infection: epidemiology, molecular characterization and imaging
东非肺癌及其与 HIV-1 感染的关系:流行病学、分子特征和影像学
- 批准号:
10267194 - 财政年份:2020
- 资助金额:
$ 31.24万 - 项目类别:
Lung cancer in East Africa and the relationship to HIV-1 infection: epidemiology, molecular characterization and imaging
东非肺癌及其与 HIV-1 感染的关系:流行病学、分子特征和影像学
- 批准号:
10478899 - 财政年份:2020
- 资助金额:
$ 31.24万 - 项目类别:
Lung cancer in East Africa and the relationship to HIV-1 infection: epidemiology, molecular characterization and imaging
东非肺癌及其与 HIV-1 感染的关系:流行病学、分子特征和影像学
- 批准号:
10084623 - 财政年份:2020
- 资助金额:
$ 31.24万 - 项目类别:
Chemoprotection & Immune Remodeling after Hematopoietic Progenitor Cell Gene Therapy for Glioblastoma
化学保护
- 批准号:
10470774 - 财政年份:2019
- 资助金额:
$ 31.24万 - 项目类别:
Chemical Inhibitors of 15-prostaglandin dehydrogenase Potentiate Hematopoietic Stem Cell Transplantation
15-前列腺素脱氢酶化学抑制剂增强造血干细胞移植
- 批准号:
9324688 - 财政年份:2017
- 资助金额:
$ 31.24万 - 项目类别:
MSC 2013: Adult Stem Cell Therapy and Regenerative Medicine
MSC 2013:成体干细胞治疗和再生医学
- 批准号:
8597780 - 财政年份:2013
- 资助金额:
$ 31.24万 - 项目类别:
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