New Faculty Recruitment to Enhance Melanoma Research

描述（申请人提供）：响应国家癌症研究所美国恢复和再投资法案（ARRA）资助的行政补充：恢复法案有限竞争：支持新的教师招聘，以加强通过生物医学研究核心中心的研究资源（P30），我们建议补充资金，以支持招聘早期调查人员和资助试点项目，这将有助于扩大一项倡议，黑色素瘤疾病集中在基础和转化研究的情况下综合癌症中心。黑色素瘤疾病团队是一个较新的活跃的合作小组，有望发展成为癌症中心内的一个重大举措。本申请中描述的招聘对于加强该集团和建立更强大的跨机构计划至关重要。我们将从开发黑色素瘤模型的集中努力中受益，并正在寻求高度合作的个人，这将提高我们对黑色素瘤发展和进展所涉及的信号机制的知识，并资助基础，转化和临床试验项目。 研究黑色素瘤的病因、发病机制和治疗的科学。试点补助金申请将通过案例CCC每周通讯，通过信件和电子邮件通知通知和通知通知所有部门主席和中心主任，并通过医学院和大学通讯的凯斯西储大学的研究社区成员征求。所有申请要求将通过案例CCC网站提供。RFA将声明，这些试点项目旨在刺激研究，扩大我们对黑色素瘤的了解，并产生和促进新的和扩大的合作，以多种方式实现ARRA的目标：1）该申请将为早期研究人员，研究助理提供就业机会，并为研究人员提供额外的努力，2）将需要购买科学材料和试剂，和3）将导致新的癌症治疗，这将对患者产生重大影响。这些疗法/技术的产生也有很大的潜力在该地区创造新的就业机会，首先是通过使用实验室人员的资金，然后通过组建新的创业企业或通过赞助研究协议支持商业发展。 公共卫生相关性：该补充支持的教师职位和试点项目将利用现有的研究，刺激进一步的研究，推进癌症中心和凯斯西储大学的研究，并提供经济刺激。

DESCRIPTION (Provided by the applicant): In response to the National Cancer Institute American Recovery and Reinvestment Act (ARRA) Funded Administrative Supplements: Recovery Act Limited Competition: Supporting New Faculty Recruitment to Enhance Research Resources through Biomedical Research Core Centers (P30), we propose a supplement to support the recruitment of early stage investigators and funding of pilot projects that will aid in the expansion of an initiative in melanoma disease focused basic and translational research at the Case Comprehensive Cancer Center. The melanoma disease team is a newer active collaborative group that is poised to grow into a major initiative within the Cancer Center. The recruitments described in this application will be critically important to the strengthening of the group and establishing a stronger cross-institutional program. We will benefit from a focused effort developing models of melanoma and are seeking highly collaborative individuals that will enhance our knowledge of the signaling mechanisms involved in melanoma development and progression as well as fund pilot projects in basic, translational and clinical research investigating the etiology, pathogenesis, and treatment of melanoma. Pilot grant applications will be solicited from members of the research community at Case Western Reserve University through Case CCC weekly newsletter, notification of all department chairs and center directors through letters and e-mail notices and notices through the School of Medicine and University newsletters. All application requirements will be available through the Case CCC web site. The RFA will state that these pilot projects are solicited to stimulate research that will expand our knowledge of melanoma, and generate and foster new and expanded collaborations to address the goals of the ARRA in multiple ways: 1) This application will provide employment for early stage investigators, research assistants and provide additional effort for research personnel, 2) will require the purchase of scientific materials and reagents, and 3) will result in new cancer treatments that will have a significant impact on patients. Generation of these therapeutics/technologies have also have a high potential for creating new jobs in the region, first by the use of funds for personnel in laboratories and later through formation of new start-up ventures or through support of commercial development via sponsored research agreements. Public Health Relevance: The faculty positions and pilot projects supported by this supplement will leverage existing research, stimulate further research, advance the research of the Cancer Center and Case Western Reserve University, and provide economic stimulation.