Spatiotemporal mapping of auditory attention using multimodal imaging

使用多模态成像进行听觉注意力的时空映射

基本信息

批准号：
8410104
负责人：
Adrian KC Lee
金额：
$ 20.64万
依托单位：
UNIVERSITY OF WASHINGTON
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-09-01 至 2015-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8410104
关键词：
Accounting Address Animal Model Attention Auditory Biological Markers Brain Complex Crowding Crying Cues Data Data Analyses Devices Dimensions Electroencephalography Engineering Environment Event Fathers Functional Magnetic Resonance Imaging Goals Hearing Hearing Aids Instruction K-Series Research Career Programs Knowledge Magnetic Resonance Imaging Magnetoencephalography Maps Masks Mentors Mothers Multimodal Imaging Neurosciences Noise Parents Pathway interactions Pattern Phase Physiologic pulse Prefrontal Cortex Protocols documentation Psychophysics Recruitment Activity Research Resolution Restaurants Scanning Science Signal Transduction Source Speech Staging Stimulus Techniques Technology Testing Time Training Translating United States National Institutes of Health Visual attention Voice Washington Work auditory stimulus base career computerized data processing data space design deviant distraction frontal eye fields image reconstruction imaging modality interest neuroimaging next generation professor programs research study response sound spatiotemporal

项目摘要

The research proposed herein aims at developing and utilizing a multimodal imaging approach to examine the underlying brain mechanism involved in auditory attention. The proposed approach is to conduct the same experiment using functional magnetic resonance imaging (fMRI) and magneto/electroencephalography (M/EEG). This powerful combination utilizes the fine spatial precision of fMRI with the high temporal resolution of M/EEG to map the spatiotemporal dynamics of the cortical networks associated with auditory attention and scene analysis. Currently, however, the acoustical noise associated with fMRI presents a technical hurdle to all auditory studies. Initial steps to characterize the acoustical noise associated with different fMRI pulse sequences are underway. During the mentored phase, the candidate will draw on his signal processing expertise to develop a noise masking protocol that will psychoacoustically control forthe auditory environment during fMRI scanning while mitigating the technical challenges in MR image reconstruction associated with the proposed auditory-amicable fMRI pulse sequence. In later stages, two experiments will be carried out examining how the prefrontal cortex is differentially involved when subjects are directed to attend different cues of the auditory stimulus. We will determine what "biomarkers" can be extracted from the M/EEG signals that are associated with the listener's attentional states. The project fits the candidate's long-term career goal of establishing a high-quality independent research program that combines engineering and neuroscience approaches in a synergistic manner to characterize the "biomarkers" that are associated with auditory scene analysis. This work will facilitate the candidate's immediate goals of becoming an expert in multimodal imaging while bringing to the field his knowledge in speech and hearing sciences, particularly his quantitative psychophysics training. The independent phase of the NIH Pathway to Independence Career Development award will be carried out at the LIniversity of Washington, Seattle, where the candidate will begin his career as assistant professor on January 1, 2011.

本文提出的研究旨在开发和利用多模式成像方法来检查涉及听觉关注的潜在大脑机制。拟议的方法是进行使用功能性磁共振成像（fMRI）和磁性/脑电图的相同实验（M/EEG）。这种功能强大的组合利用了fMRI的精细空间精度和高时间 M/EEG的分辨率绘制与听觉相关的皮质网络的时空动力学注意力和场景分析。但是，目前，与fMRI相关的声学噪声呈现出A 所有听觉研究的技术障碍。最初的步骤来表征与之相关的声学噪声不同的fMRI脉冲序列正在进行中。在指导阶段，候选人将借鉴他的信号处理专业知识，以开发噪声掩盖协议，该协议将心理上控制功能磁共振成像扫描期间的听觉环境，同时减轻MR图像中的技术挑战与所提出的听觉功能型fMRI脉冲序列相关的重建。在以后的阶段，两个将进行实验，以检查受试者时前额叶皮层如何差异被指示参加听觉刺激的不同提示。我们将确定什么是“生物标志物” 从与听众注意状态相关的M/EEG信号中提取。该项目适合候选人的长期职业目标是建立一项高质量的独立研究计划结合工程学和神经科学方法以协同的方式表征与听觉场景分析相关的“生物标志物”。这项工作将促进候选人的成为多模式成像专家的直接目标，同时将自己的知识带入领域言语和听力科学，尤其是他的定量心理物理学培训。独立阶段 NIH独立职业发展奖将在西雅图华盛顿，候选人将于2011年1月1日开始担任助理教授的职业。