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Dynamics of targeted gene knockdowns in A. burtoni

Dynamics of targeted gene knockdowns in A. burtoni
伯托尼靶向基因敲低的动态
批准号：
8568559
负责人：
RUSSELL D FERNALD
金额：
$7.85万
依托单位：
STANFORD UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
项目状态：
已结题
起止时间：
2013-08-01 至 2015-07-31
来源：
https://reporter.nih.gov/project-details/8568559
关键词：
AdultAfricaAfricanAnimalsAntisense OligonucleotidesBehaviorBehavior ControlBehavioralBehavioral ModelBiological ModelsCandidate Disease GeneCichlidsCodeComplexCuesEmbryoEnvironmentFunctional RNAGene ExpressionGene Expression ProfileGene SilencingGene TargetingGenesGenomeGenomicsGoalsHumanMapsMeasuresMental DepressionMental disordersMethodsMicroRNAsModelingMolecularNeuronal PlasticityNeuronsOutcomePatternPenetrancePhenotypePhysiologicalPilot ProjectsRoleSchizophreniaSocial BehaviorSocial statusSystemTechniquesTestingTissuesToxic effectTranscriptTransgenic AnimalsTransgenic Organismsanimal datagenome sequencingin vivonovelpublic health relevanceresearch studyresponsesocialtooltranscriptomics

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DESCRIPTION (provided by applicant): This project will develop gene knockdown methods for a novel behavioral model system. Animals we study respond to social cues behaviorally and physiologically, changing phenotype as they ascend or descend in social status. Specifically, we can manipulate the social system to mimic the natural environment and have identified neurons that respond to social information. We have collected gene expression data from animals of distinct, socially regulated phenotypes producing candidate genes that putatively regulate social behavior. We will develop methods to silence gene expression to test which genes are responsible for particular aspects of behavioral change.
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Social regulation of transcription and methylation networks in the brain
  • 批准号：
    8952352
  • 项目类别：
  • 资助金额：
    $28.09万
  • 财政年份：
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  • 负责人：
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    8631179
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  • 财政年份：
    2014
  • 负责人：
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  • 依托单位：
    GEORGIA INSTITUTE OF TECHNOLOGY
Castles made of sand: The genomics of complex behavior
  • 批准号：
    8842658
  • 项目类别：
  • 资助金额：
    $28.81万
  • 财政年份：
    2014
  • 负责人：
    RUSSELL D FERNALD
  • 依托单位：
    GEORGIA INSTITUTE OF TECHNOLOGY
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  • 批准号：
    9058100
  • 项目类别：
  • 资助金额：
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  • 依托单位：
    GEORGIA INSTITUTE OF TECHNOLOGY
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