Pharmacology and Neurotherapeutics Program (PTNP)

药理学和神经治疗计划（PTNP）

• 批准号: 8655003
• 负责人: ROSE HOOD
• 金额: $ 20.48万
• 依托单位: SOUTHERN RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-03-29 至 2014-03-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8655003
• 关键词: Area; Communication; Contractor; Contracts; Development; District of Columbia; Drug Kinetics; Hour; In Vitro; Lead; Persons; Pharmaceutical Chemistry; Pharmacology; Preparation; Process; Reporting; Series; Support Contracts; Testing; Therapeutic; Toxic effect; United States National Institutes of Health; Writing; base; drug development; drug discovery; in vivo; meetings; nervous system disorder; programs; symposium

The NIH Blueprint Neurotherapeutics Network (BPN) has initiated a series of collaborative drug discovery and development projects focused on nervous system disorders. These projects will be developing therapeutic leads through an iterative process of medicinal chemistry optimization and in vitro and in vivo testing. A component of this process will be the conduct of pharmacokinetic (PK) and toxicity assessment of compounds developed through the BPN. This task will cover all tasks related to general contract administration for the period of 9/13/2012-9/12/2013.

NIH Blueprint Neurotherapeutics Network（BPN）发起了一系列专注于神经系统疾病的合作药物发现和开发项目。这些项目将通过药物化学优化以及体外和体内测试的迭代过程开发治疗线索。该过程的一个组成部分是对通过BPN开发的化合物进行药代动力学（PK）和毒性评估。这项任务将涵盖2012年9月13日至2013年9月12日期间与总合同管理有关的所有任务。