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IGF::OT::IGF "Rodent Pharmacokinetic and Brain Level Determination"

IGF::OT::IGF "Rodent Pharmacokinetic and Brain Level Determination"
IGF::OT::IGF“啮齿动物药代动力学和脑水平测定”
批准号：
8759147
负责人：
ROSE HOOD
金额：
$9.99万
依托单位：
SOUTHERN RESEARCH INSTITUTE
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
项目状态：
已结题
起止时间：
2013-09-13 至 2014-09-12
来源：
https://reporter.nih.gov/project-details/8759147
关键词：
AcuteBiologicalBiological AssayBrainClinicalContractorContractsCytochrome P450DevelopmentDoseDrug KineticsEvaluationHepatotoxicityIn VitroInvestigational New Drug ApplicationLeadLiquid substanceMetabolicPermeabilityPharmaceutical PreparationsPharmacology and ToxicologyPlasma ProteinsProtein BindingProtocols documentationResearch PersonnelRodentRouteSolutionsTestingTissuesToxic effectUnited States National Institutes of HealthValidationanalytical methoddrug developmentgenotoxicityin vivopre-clinicalresearch clinical testing

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英文摘要
1. Pharmacology and toxicology facilities (PTNPs). As detailed in this SOW, the PTNP Contractor(s) will provide all preclinical pharmacology and toxicology testing needed to inform lead optimization and the selection of a clinical candidate, and testing required for an Investigational New Drug (IND) application for the FDA to support clinical evaluation of the compound. 2. The Contractor shall conduct both non-GLP and GLP toxicology and pharmacology studies in accordance with the complete protocol requirements for each agent developed by the Contractor and approved by the NIH Project Officer, and, when appropriate, in compliance with the requirements of the FDA. 3.
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IGF::OT::IGF "Pharmacology and Toxicology for Neurotherapeutics (PTNP)"
  • 批准号：
    8759765
  • 项目类别：
  • 资助金额：
    $9.92万
  • 财政年份：
    2013
  • 负责人：
    ROSE HOOD
  • 依托单位：
    SRI INTERNATIONAL
Pharmacology and Neurotherapeutics Program (PTNP)
  • 批准号：
    8655003
  • 项目类别：
  • 资助金额：
    $20.48万
  • 财政年份：
    2013
  • 负责人：
    ROSE HOOD
  • 依托单位：
    SOUTHERN RESEARCH INSTITUTE
Development and Maintenance of a Multigenotypic Aged Rat Colony
IGF::OT::IGF "In Vivo Metabolite ID Study"
  • 批准号：
    8764091
  • 项目类别：
  • 资助金额：
    $18.78万
  • 财政年份：
    2013
  • 负责人：
    ROSE HOOD
  • 依托单位：
    SRI INTERNATIONAL
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