IGF::OT::IGF "Rodent Dose-Range Finding Toxicology"

1. 药理学和毒理学设施（PTNPs）。如本SOW中所述，PTNP承包商将提供所有临床前药理学和毒理学测试，以指导先导优化和临床候选药物的选择，以及FDA在研新药（IND）申请所需的测试，以支持该化合物的临床评估。

1. Pharmacology and toxicology facilities (PTNPs). As detailed in this SOW, the PTNP Contractor(s) will provide all preclinical pharmacology and toxicology testing needed to inform lead optimization and the selection of a clinical candidate, and testing required for an Investigational New Drug (IND) application for the FDA to support clinical evaluation of the compound. 2. The Contractor shall conduct both non-GLP and GLP toxicology and pharmacology studies in accordance with the complete protocol requirements for each agent developed by the Contractor and approved by the NIH Project Officer, and, when appropriate, in compliance with the requirements of the FDA. 3. The Contractor may be required to support drug development projects within the scope of this contract from investigators outside of the Blueprint Network.