Development of genetic tools to study central Avp1b receptors

开发研究中枢 Avp1b 受体的遗传工具

• 批准号: 8550134
• 负责人: Heather Kingsley Caldwell
• 金额: $ 7.07万
• 依托单位: KENT STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-24 至 2015-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8550134
• 关键词: Affect; Aggressive behavior; Animal Model; Applications Grants; Argipressin; Behavior; Behavioral; Data; Development; Disease; Foundations; Future; Genetic; Goals; Human; Inbreeding; Investigation; Knowledge; Laboratories; Learning; Memory; Mental Health; Mental disorders; Mesocricetus auratus; Microtus; Mission; Modeling; Mus; National Institute of Mental Health; Neuroendocrinology; Neuropeptides; Outcome; Play; Public Health; RNA Interference; Rattus; Research; Resources; Rodent; Role; Schizophrenia; Severities; Signal Transduction; Site; Social Behavior; Social Interaction; Structure; System; Testing; United States National Institutes of Health; V1a vasopressin receptor; V1b vasopressin receptor; Vasopressins; Viral Vector; Vision; Work; argipressin receptor; autism spectrum disorder; design; finesse; improved; innovation; insight; neurochemistry; neuropsychiatry; neuroregulation; overexpression; prairie vole; public health relevance; receptor; research study; social; social attachment; tool; vector

DESCRIPTION (provided by applicant): In humans, there is evidence that the neuropeptide vasopressin may play a role in the development and/or severity of mental health disorders characterized by aberrant social behavior, such as schizophrenia and autism spectrum disorders. The objective of this R03 application is to develop genetic tools for the exploration of the role of the vasopressin 1b receptor in species that are behaviorally rich and in which vasopressin is known to be important to the neural regulation of social behavior, specifically, Syrian hamsters and prairie voles. The proposed experiments have been designed to test the central hypothesis that across mammalian species the vasopressin 1b receptor is conserved in sequence, distribution, and function. This knowledge is relevant to the mission of the NIMH because it will further our knowledge of the neurochemistry underlying psychiatric disorders characterized by abnormal social behavior. One specific aim is proposed that is designed to determine the sequence and distribution of the vasopressin 1b receptor in Syrian hamsters and prairie voles, as well as to develop genetic tools to use in future functional studies. The proposed research is significant because by determining how conserved the vasopressin 1b system is and how it modulates social behavior and our understanding of the vasopressin system in humans can be improved.

描述（由申请人提供）：在人类中，有证据表明神经肽血管加压素可能在以异常社会行为为特征的精神健康障碍（如精神分裂症和自闭症谱系障碍）的发展和/或严重程度中发挥作用。该R 03应用程序的目标是开发遗传工具，用于探索 加压素1b受体在行为丰富的物种中的作用，已知加压素对社会行为的神经调节很重要，特别是叙利亚仓鼠和草原田鼠。拟议的实验已被设计为测试的中心假设，在哺乳动物物种的加压素1b受体是保守的序列，分布和功能。这些知识与NIMH的使命相关，因为它将进一步加深我们对以异常社会行为为特征的精神障碍的神经化学基础的认识。提出了一个具体的目标，旨在确定叙利亚仓鼠和草原田鼠的血管加压素1b受体的序列和分布，以及开发遗传工具，用于未来的功能研究。这项研究意义重大，因为通过确定加压素1b系统的保守程度以及它如何调节社会行为，我们可以提高对人类加压素系统的理解。