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Identification of a Site Critical to the Avpr1b's Effects on Behavior

识别对 Avpr1b 对行为的影响至关重要的位点

基本信息

批准号：
7835637
负责人：
Heather Kingsley Caldwell
金额：
$ 17.64万
依托单位：
KENT STATE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-05-07 至 2012-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7835637
关键词：
Affect Aggressive behavior Animals Applications Grants Area Argipressin Behavior Behavioral Biological Biological Assay Borderline Personality Disorder Brain Brain region Cell Culture Techniques Coupling Data Development Experimental Animal Model Foundations Future Gene Targeting Genes Goals Hamsters Health Hippocampus (Brain)Human Knockout Mice Knowledge Laboratories Lead Lesion Location Mediating Memory Mental disorders Mission Molecular Motivation Mus Neuraxis Neuropeptides Neurotransmitters Outcome Pathway interactions Public Health Qualifying Reagent Regulation Research Role Schizophrenia Signal Transduction Site Social Behavior System Testing Vasopressins Work autism spectrum disorder design in vivo innovation neurochemistry neuroregulation new therapeutic target public health relevance receptor receptor-mediated signaling relating to nervous system research study social

项目摘要

DESCRIPTION (provided by applicant): The vasopressin 1b receptor has been consistently implicated as a key factor in the regulation of social behavior; however, the precise region of the brain where the vasopressin 1b receptor is acting has not been identified. The objective in this application is to identify neural substrates on which vasopressin acts via the vasopressin 1b receptor to affect social behavior in an experimental animal model. Specifically, the proposed experiments have been designed to test the central hypothesis that vasopressin 1b receptor mediated-signaling, specifically within the CA2 region of the hippocampus, contributes to normal displays of social behavior. The rationale for these studies is that identification of the neuroanatomical substrate upon which vasopressin acts via the vasopressin 1b receptor to impact social behavior will potentially further our understanding of aberrant social behavior. This knowledge is relevant to the NIH's mission in that it will potentially provide new targets for psychiatric disease treatment in humans. The specific aim of this proposal is to determine the contribution of the vasopressin 1b receptor within the CA2 region of the hippocampus to social behavior. This will be achieved by coupling experimental animal behavioral studies with targeted, site-specific, gene knockdown to identify pathways important to the regulation of behavior. It is expected that completion of this research will lead to the identification of one of the important neural substrates contributing to the vasopressin 1b receptor's regulation of social behavior. The proposed research is significant because the findings of this work will serve as a foundation for a more focused examination of the interaction between vasopressin and other neurotransmitter systems; ultimately resulting in a more complete understanding of the regulation of social behavior. PUBLIC HEALTH RELEVANCE The proposed studies are important because they have the potential to identify one of the key neural substrates that likely contributes to manifestations of aberrant social behavior. The proposed research has relevance to public health, because the neurochemicals, neurosubstrates, and circuits that underlying the regulation of behavior are evolutionarily conserved. Thus, the findings are ultimately expected to be applicable to the health of human beings.

描述（由申请人提供）：加压素1b受体一直被认为是调节社会行为的关键因素;然而，加压素1b受体起作用的大脑精确区域尚未确定。本申请的目的是在实验动物模型中鉴定加压素通过加压素1b受体作用于其上以影响社会行为的神经底物。具体来说，拟议的实验旨在测试中心假设，即加压素1b受体介导的信号传导，特别是海马体CA 2区域内的信号传导，有助于正常的社会行为表现。这些研究的基本原理是，确定加压素通过加压素1b受体影响社会行为的神经解剖学底物，可能会进一步加深我们对异常社会行为的理解。这些知识与NIH的使命相关，因为它可能为人类精神疾病治疗提供新的靶点。这项建议的具体目的是确定海马CA 2区内的加压素1b受体对社会行为的贡献。这将通过将实验动物行为研究与靶向的、位点特异性的基因敲除相结合来实现，以确定对行为调节重要的途径。预计这项研究的完成将导致识别一种重要的神经底物，有助于加压素1b受体调节社会行为。拟议的研究是重要的，因为这项工作的结果将作为一个基础，更集中的检查加压素和其他神经递质系统之间的相互作用，最终导致更完整的理解社会行为的调节。公共卫生相关性拟议的研究是重要的，因为它们有可能确定一个关键的神经基质，可能有助于异常的社会行为的表现。这项拟议中的研究与公共卫生有关，因为神经化学物质、神经基质和行为调节的回路在进化上是保守的。因此，这些发现最终有望适用于人类的健康。