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Understanding the central embryonic vasopressin system

了解中央胚胎加压素系统

基本信息

批准号：
10580287
负责人：
Heather Kingsley Caldwell
金额：
$ 45.6万
依托单位：
KENT STATE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-01-02 至 2025-12-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10580287
关键词：
Adult Affect Aggressive behavior Animal Model Anxiety Applications Grants Behavior Brain Brain region Chemicals Data Development Diagnosis Disease Embryo Embryonic Development Female Financial Support Goals Health Human Hypothalamic structure Impairment Individual Intervention Laboratories Ligands Link Maternal Behavior Measures Mental Depression Messenger RNA Mus Neurodevelopmental Disorder Neuroglia Neurons Play Positioning Attribute Receptor Signaling Regulation Reporting Research Role Scientist Sex Bias Sex Differences Shapes Signal Transduction Social Behavior Social Functioning Structure System Testing Time Vasopressin Receptor Vasopressins Work clinically relevant experimental study gliogenesis graduate student innovation insight male maternal aggression memory recognition neural neural circuit neurodevelopment neurogenesis neuropsychiatric disorder neuroregulation pre-clinical receptor sex social undergraduate student

项目摘要

PROJECT SUMMARY Compelling evidence suggests that the central embryonic vasopressin system has a role to play in sex-specific brain development and subsequent behavior. The vasopressin system is present and functional during embryonic development, with sex differences in the expression of the ligand. However, very little is known about the structure or function of this system. Thus, the working hypothesis of this R15 proposal is that the central embryonic vasopressin system, and specifically vasopressin 1a receptor signaling, directly contributes to the development of the neural circuitry that supports social behavior in females and males. To test this hypothesis three specific aims are proposed. The first aim will define the structural details of the developing vasopressin system in females and males. The second aim will determine how embryonic vasopressin receptor signaling impacts female and male brain development. The third aim will establish that embryonic vasopressin receptor signaling has sex-specific effects on social behavior. The proposed research is scientifically important because understanding how the embryonic vasopressin system affects sex-specific brain development and social behavior in mice has implications for humans. Specifically, several neuropsychiatric disorders with neurodevelopmental origins, many of which have a known sex-bias skewed towards males, are associated with impairments in social behaviors that have been linked to the vasopressin system. Thus, the data generated from the proposed experiments will provide critical insights into some of the shared origins of these disorders and will move us closer to more targeted interventions.

项目总结令人信服的证据表明，中枢胚胎加压素系统在性别特异性中发挥作用。大脑发育和随后的行为。后叶加压素系统存在，并在胚胎发育过程中，具有性别差异的配体表达。然而，人们对此知之甚少。关于这个系统的结构或功能。因此，这个R15提案的工作假设是中枢胚胎加压素系统，特别是加压素1a受体信号，直接起作用。对支持女性和男性社交行为的神经回路的发展。为了测试这一点假设提出了三个具体目标。第一个目标将定义开发的结构细节女性和男性的加压素系统。第二个目标将决定胚胎加压素如何受体信号影响女性和男性的大脑发育。第三个目标将建立萌芽状态加压素受体信号对社会行为有性别特异性的影响。拟议的研究是科学上很重要，因为了解胚胎加压素系统是如何影响性别特异性的老鼠的大脑发育和社会行为对人类有影响。具体地说，有几个起源于神经发育的神经精神障碍，其中许多具有已知的性别偏见对男性来说，与社会行为的损害有关，这与加压素有关系统。因此，从拟议的实验产生的数据将为一些关键的洞察力提供这些疾病的共同根源，将使我们更接近更有针对性的干预措施。