Complex Sound Perception in Mice

小鼠的复杂声音感知

• 批准号: 8433872
• 负责人: MICHEAL L DENT
• 金额: $ 38.65万
• 依托单位: STATE UNIVERSITY OF NEW YORK AT BUFFALO
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-12-01 至 2017-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8433872
• 关键词: Acoustics; Address; Adolescent; Adult; Animal Behavior; Animal Model; Animals; Attention; Auditory; Auditory system; Behavioral; Biological Models; Categories; Characteristics; Communication; Complex; Detection; Discrimination; Environment; Eye; Female; Frequencies; Genes; Genetic; Goals; Hearing; Hearing problem; Human; Laboratories; Language; Language Disorders; Masks; Measures; Modeling; Molecular; Molecular Biology; Molecular Genetics; Mus; Nature; Operant Conditioning; Pathology; Physiological; Physiology; Process; Psychophysics; Publishing; Research; Resolution; Signal Transduction; Sound Localization; Space Perception; Speech; Speech Disorders; Stimulus; Structure; Testing; Ultrasonics; awake; base; design; falls; male; mouse model; public health relevance; relating to nervous system; research study; sound; vocalization

DESCRIPTION (provided by applicant): The overall objective of the proposed experiments is to characterize ultrasonic communication in mice. The mouse is widely used in studies of the auditory system and is thought to be a good model for human communication and audition, yet we know very little about the nature of the mouse's acoustic world. Humans characterizing the vocalizations of mice have been known to place the calls into anywhere from three to six total categories of vocalization types. The proposed studies will avoid human-based categorizations by asking the mouse directly whether they can discriminate or identify calls and whether they have enhanced capabilities for perceptually processing call-like sounds. Ultrasonic vocalizations from juveniles and adults will be recorded and then those same vocalizations will be used in perceptual studies in awake, behaving mice. These studies are urgently needed in the field of audition because so many laboratories regularly use the mouse as a model for hearing and communication in humans and now the differences and commonalities between the two species can be understood and utilized.

描述(由申请人提供)：拟议实验的总体目标是表征小鼠的超声波通讯。老鼠被广泛用于研究听觉系统，被认为是人类交流和听力的良好模型，但我们对老鼠的听觉世界的性质知之甚少。众所周知，以老鼠发声为特征的人类会发出三到六种发声类型的呼叫。这项拟议的研究将避免基于人类的分类，直接询问鼠标是否能够辨别或识别呼叫，以及它们是否具有增强的感知处理类似呼叫的声音的能力。青少年和成年人的超声波发声将被记录下来，然后这些相同的发声将被用于清醒、行为正常的小鼠的知觉研究。这些研究在听力领域是迫切需要的，因为有如此多的实验室经常使用小鼠作为人类听力和交流的模型，现在可以理解和利用这两个物种之间的差异和共同点。