Age-related hearing deficits in noise-exposed mouse models of Alzheimer's Disease

暴露于噪音的阿尔茨海默病小鼠模型中与年龄相关的听力缺陷

• 批准号: 10284502
• 负责人: MICHEAL L DENT
• 金额: $ 28.7万
• 依托单位: STATE UNIVERSITY OF NEW YORK AT BUFFALO
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-05-01 至 2023-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10284502
• 关键词: APP-PS1; Acoustic Trauma; Acoustics; Address; Affect; Age; Age-Months; Aging; Alzheimer' s Disease; Alzheimer' s disease model; Alzheimer' s disease risk; Anatomy; Auditory; Auditory Brainstem Responses; Auditory area; Awareness; Behavioral; CBA/CaJ Mouse; Chronic; Communication; Controlled Environment; Detection; Environment; Environmental Risk Factor; Exposure to; Female; Genetic Predisposition to Disease; Genetic Risk; Goals; Health; Hearing; Hearing problem; Human; Knowledge; Laboratory mice; Learning; Link; Longevity; Loudness; Measures; Methodology; Modeling; Mus; Nature; Noise; Nose; Operant Conditioning; Pathology; Patients; Physiological; Play; Positive Reinforcements; Predisposition; Presbycusis; Procedures; Process; Publishing; Reporting; Research; Research Proposals; Role; Sex Differences; Speech; Study models; Sum; Techniques; Training; Transgenic Mice; Wild Type Mouse; age difference; age effect; awake; behavior measurement; early onset; experience; experimental study; genetic variant; hearing impairment; male; mouse model; mutant; parent grant; parent project; sex; speech in noise

Summary It is well known that Alzheimer's disease (AD) and hearing loss often occur together. What is unknown, however, is the relationship between noise exposures and patients with AD. Our goal with this supplement is to examine the link between noise exposure, age, listening environment (noise or quiet), and sex in transgenic mouse models of AD compared to wild-type mice. In our one Specific Aim, we will behaviorally measure auditory acuity before and after noise exposures in the above groups of mice and the two listening environments to determine if young AD mutants are more susceptible to noise exposure than young wild-type mice, and to examine the differences of the susceptibility to noise in quiet and noise environments. In our parent grant, we have been measuring the effects of noise on hearing in young and old, male and female mice, and have found that old mice suffer greater hearing loss post-noise exposure than young mice when listening in quiet environments, but not in noisy environments. This supplement will utilize the same techniques in two mouse models of AD to determine if young AD mice act like old wild-type mice in terms of susceptibility to hearing loss following acoustic trauma. Although these mouse models are commonly used to study the anatomical correlates of AD, we are only beginning to comprehend the functional implications of AD on hearing, especially hearing in noise, and these experiments will help us better understand how aging, sex, and noise all play a role in the communication problems faced by patients with AD.

摘要 众所周知，阿尔茨海默病(AD)和听力损失经常同时发生。什么是未知的， 然而，噪声暴露与AD患者之间的关系。我们使用这份补充材料的目的是 在转基因研究中检查噪音暴露、年龄、听力环境(噪音或安静)和性别之间的联系 将AD小鼠模型与野生型小鼠进行比较。在我们的一个特定目标中，我们将从行为上衡量 上述两组小鼠在噪声暴露前后的听觉敏锐度 确定年轻的AD突变体是否比年轻的野生型更容易受到噪音影响的环境 研究安静和噪声环境下小鼠对噪声的易感性的差异。在我们的 Parent Grant，我们一直在测量噪音对年轻人和老年人，男性和女性听力的影响 小鼠，并发现老年小鼠在噪声暴露后比年轻小鼠遭受更大的听力损失 在安静的环境中倾听，但不在嘈杂的环境中倾听。本副刊将利用相同的 在两种阿尔茨海默病小鼠模型中的技术，以确定年轻的阿尔茨海默病小鼠在以下方面是否表现为老年野生型小鼠 听力损伤后听力损失的易感性。尽管这些鼠标模型通常用于 研究阿尔茨海默病的解剖学相关性，我们才刚刚开始理解阿尔茨海默病的功能含义 这些实验将帮助我们更好地理解年龄，性别， 和噪音都在阿尔茨海默病患者面临的沟通问题中发挥了作用。