Age differences in perceptual consequences of noise exposure
噪声暴露感知后果的年龄差异
基本信息
- 批准号:10392912
- 负责人:
- 金额:$ 33.54万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2018
- 资助国家:美国
- 起止时间:2018-05-10 至 2024-04-30
- 项目状态:已结题
- 来源:
- 关键词:Acoustic NerveAcoustic TraumaAddressAdultAffectAfferent NeuronsAgeAnatomyAnimal ModelAnimalsAuditoryAuditory Brainstem ResponsesAuditory PerceptionAuditory systemBehavioralBiologicalBiological AssayBiological FactorsBrainBrain StemCochleaCochlear nucleusComplexComputer softwareConfocal MicroscopyCuesDataDependenceDetectionDevelopmentDiscriminationElderlyElectrophysiology (science)EnvironmentExcitatory SynapseExhibitsExposure toFinancial compensationFrequenciesFunctional disorderGoalsHair CellsHealthHearingHearing TestsHumanHyperactivityImageImmunohistochemistryImpairmentInhibitory SynapseInvestigationKnowledgeLabelLeadLinkMasksMeasuresModelingMusNeurosciencesNoiseNoise-Induced Hearing LossOutcomePathologyPatientsPatternPerceptionPerformancePeripheralPhysiologicalPredispositionPreventiveProceduresProcessPsychoacousticsRecoveryResearchRoleSignal TransductionSpeech PerceptionSpeech SoundStimulusSynapsesTechniquesTestingTherapeuticTimeTrainingage differenceage relatedbasebehavior measurementbehavioral impairmentbrain tissuecohortexperimental studyfunctional lossfunctional outcomeshearing impairmentmature animalmiddle agemouse modelnerve damagenoise exposurenotch proteinpre-clinical assessmentresponsesoundspeech in noisetoolvocalizationyoung adult
项目摘要
PROJECT SUMMARY:
Synaptopathy, loss of functional synapse between hair cells and their afferent neurons, is thought
to be of central importance in the development of auditory deficits such as speech perception and
sound discrimination in noisy environments. Noise exposure during the lifetime is thought to be
an important contributing factor to synaptopathy. Investigation of this problem is difficult in humans
in part due to the difficulty confirming loss of auditory synapses in living humans and the limited
knowledge of the effects of biological variables such as age on noise-induced synaptopathy.
Importantly, synaptopathy can experimentally investigated in animal models such as mice, which
have emerged as a leading research tool in auditory neuroscience. The overall objective of the
proposed experiments is to identify age-dependent effects of noise exposure in a mouse model
of noise-induced synaptopathy. The proposed studies will apply a battery of well-defined
psychoacoustic tests in a well-controlled mouse model of synaptopathy. The mouse model affords
us the opportunity to screen animals exposed as young or older adults to synaptopathy-inducing
noise on behavioral and electrophysiological measures to detect dysfunction in addition to
performing anatomical assays to confirm the pattern of auditory nerve synapse loss and central
reorganization. We will pursue our objective through three aims: 1) Measure the effects of noise
exposure on the perception of spectral, temporal, and intensity cues in young and old mice; 2)
Measure the effects of noise exposure on the perception of spectrotemporally complex stimuli; 3)
Measure central gain compensation and the underlying changes in synaptic reorganization in the
auditory brainstem. We will test for synaptopathy-related perceptual deficits in young and old mice
trained to detect or discriminate sounds in quiet and noise. Our preliminary data indicate that old-
exposed mice cannot recover as well as younger-exposed mice, and we hypothesize that this is
due to reduced central compensation in the older brain. Auditory nerve synapse numbers will be
quantified in all mice so that behavioral and physiological response patterns can be correlated
with patterns of peripheral synapse loss and central reorganization. The experiments outlined
here will reveal a suite of behavioral measures that can be used by clinicians to reveal
synaptopathy in human patients and will identify whether or not ABRs can be optimized to detect
synaptopathy.
项目总结:
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
MICHEAL L DENT其他文献
MICHEAL L DENT的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('MICHEAL L DENT', 18)}}的其他基金
Behavioral and physiological measurements of hearing in mouse models of Alzheimer's Disease
阿尔茨海默病小鼠模型听力的行为和生理测量
- 批准号:
10647340 - 财政年份:2023
- 资助金额:
$ 33.54万 - 项目类别:
Behavioral and physiological measurements of hearing in mouse models of Alzheimer's Disease
阿尔茨海默病小鼠模型听力的行为和生理测量
- 批准号:
10878437 - 财政年份:2023
- 资助金额:
$ 33.54万 - 项目类别:
Supplement for temporal bone tissue scanning equipment
颞骨组织扫描设备的补充
- 批准号:
10449921 - 财政年份:2018
- 资助金额:
$ 33.54万 - 项目类别:
Age-related hearing deficits in noise-exposed mouse models of Alzheimer's Disease
暴露于噪音的阿尔茨海默病小鼠模型中与年龄相关的听力缺陷
- 批准号:
10284502 - 财政年份:2018
- 资助金额:
$ 33.54万 - 项目类别:
Age differences in perceptual consequences of noise exposure
噪声暴露感知后果的年龄差异
- 批准号:
9914000 - 财政年份:2018
- 资助金额:
$ 33.54万 - 项目类别:
相似海外基金
Strial vascular pathology from acoustic trauma
声损伤引起的心房血管病理学
- 批准号:
10174903 - 财政年份:2017
- 资助金额:
$ 33.54万 - 项目类别:
Cellular biological investigation of cochlear function after acoustic trauma in animals models.
动物模型声损伤后耳蜗功能的细胞生物学研究。
- 批准号:
24791814 - 财政年份:2012
- 资助金额:
$ 33.54万 - 项目类别:
Grant-in-Aid for Young Scientists (B)
Pathological ensembles in the auditory thalamocortical circuit following acoustic trauma
声损伤后听觉丘脑皮层回路的病理整体
- 批准号:
MR/J004448/1 - 财政年份:2012
- 资助金额:
$ 33.54万 - 项目类别:
Research Grant
A study of inner ear immune response after acoustic trauma
声损伤后内耳免疫反应的研究
- 批准号:
21791602 - 财政年份:2009
- 资助金额:
$ 33.54万 - 项目类别:
Grant-in-Aid for Young Scientists (B)