Age differences in perceptual consequences of noise exposure

噪声暴露感知后果的年龄差异

基本信息

  • 批准号:
    10392912
  • 负责人:
  • 金额:
    $ 33.54万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2018
  • 资助国家:
    美国
  • 起止时间:
    2018-05-10 至 2024-04-30
  • 项目状态:
    已结题

项目摘要

PROJECT SUMMARY: Synaptopathy, loss of functional synapse between hair cells and their afferent neurons, is thought to be of central importance in the development of auditory deficits such as speech perception and sound discrimination in noisy environments. Noise exposure during the lifetime is thought to be an important contributing factor to synaptopathy. Investigation of this problem is difficult in humans in part due to the difficulty confirming loss of auditory synapses in living humans and the limited knowledge of the effects of biological variables such as age on noise-induced synaptopathy. Importantly, synaptopathy can experimentally investigated in animal models such as mice, which have emerged as a leading research tool in auditory neuroscience. The overall objective of the proposed experiments is to identify age-dependent effects of noise exposure in a mouse model of noise-induced synaptopathy. The proposed studies will apply a battery of well-defined psychoacoustic tests in a well-controlled mouse model of synaptopathy. The mouse model affords us the opportunity to screen animals exposed as young or older adults to synaptopathy-inducing noise on behavioral and electrophysiological measures to detect dysfunction in addition to performing anatomical assays to confirm the pattern of auditory nerve synapse loss and central reorganization. We will pursue our objective through three aims: 1) Measure the effects of noise exposure on the perception of spectral, temporal, and intensity cues in young and old mice; 2) Measure the effects of noise exposure on the perception of spectrotemporally complex stimuli; 3) Measure central gain compensation and the underlying changes in synaptic reorganization in the auditory brainstem. We will test for synaptopathy-related perceptual deficits in young and old mice trained to detect or discriminate sounds in quiet and noise. Our preliminary data indicate that old- exposed mice cannot recover as well as younger-exposed mice, and we hypothesize that this is due to reduced central compensation in the older brain. Auditory nerve synapse numbers will be quantified in all mice so that behavioral and physiological response patterns can be correlated with patterns of peripheral synapse loss and central reorganization. The experiments outlined here will reveal a suite of behavioral measures that can be used by clinicians to reveal synaptopathy in human patients and will identify whether or not ABRs can be optimized to detect synaptopathy.
项目总结:

项目成果

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MICHEAL L DENT其他文献

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{{ truncateString('MICHEAL L DENT', 18)}}的其他基金

Behavioral and physiological measurements of hearing in mouse models of Alzheimer's Disease
阿尔茨海默病小鼠模型听力的行为和生理测量
  • 批准号:
    10647340
  • 财政年份:
    2023
  • 资助金额:
    $ 33.54万
  • 项目类别:
Behavioral and physiological measurements of hearing in mouse models of Alzheimer's Disease
阿尔茨海默病小鼠模型听力的行为和生理测量
  • 批准号:
    10878437
  • 财政年份:
    2023
  • 资助金额:
    $ 33.54万
  • 项目类别:
Supplement for temporal bone tissue scanning equipment
颞骨组织扫描设备的补充
  • 批准号:
    10449921
  • 财政年份:
    2018
  • 资助金额:
    $ 33.54万
  • 项目类别:
Age-related hearing deficits in noise-exposed mouse models of Alzheimer's Disease
暴露于噪音的阿尔茨海默病小鼠模型中与年龄相关的听力缺陷
  • 批准号:
    10284502
  • 财政年份:
    2018
  • 资助金额:
    $ 33.54万
  • 项目类别:
Age differences in perceptual consequences of noise exposure
噪声暴露感知后果的年龄差异
  • 批准号:
    9914000
  • 财政年份:
    2018
  • 资助金额:
    $ 33.54万
  • 项目类别:
Complex Sound Perception in Mice
小鼠的复杂声音感知
  • 批准号:
    9174901
  • 财政年份:
    2012
  • 资助金额:
    $ 33.54万
  • 项目类别:
Complex Sound Perception in Mice
小鼠的复杂声音感知
  • 批准号:
    8766553
  • 财政年份:
    2012
  • 资助金额:
    $ 33.54万
  • 项目类别:
Complex Sound Perception in Mice
小鼠的复杂声音感知
  • 批准号:
    8433872
  • 财政年份:
    2012
  • 资助金额:
    $ 33.54万
  • 项目类别:
Complex Sound Perception in Mice
小鼠的复杂声音感知
  • 批准号:
    8960929
  • 财政年份:
    2012
  • 资助金额:
    $ 33.54万
  • 项目类别:
Complex Sound Perception in Mice
小鼠的复杂声音感知
  • 批准号:
    8580929
  • 财政年份:
    2012
  • 资助金额:
    $ 33.54万
  • 项目类别:

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声损伤引起的心房血管病理学
  • 批准号:
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  • 财政年份:
    2017
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Pharmacology of Rescue from Acoustic Trauma
声损伤救援的药理学
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    8610289
  • 财政年份:
    2013
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  • 项目类别:
Pharmacology of Rescue from Acoustic Trauma
声损伤救援的药理学
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  • 财政年份:
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  • 批准号:
    24791814
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Pathological ensembles in the auditory thalamocortical circuit following acoustic trauma
声损伤后听觉丘脑皮层回路的病理整体
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    MR/J004448/1
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    2012
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    $ 33.54万
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    Research Grant
Drug-induced Protection from Acoustic Trauma
药物引起的声损伤保护
  • 批准号:
    8092119
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    2011
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Drug-induced Protection from Acoustic Trauma
药物引起的声损伤保护
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    8248198
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声损伤后内耳免疫反应的研究
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    21791602
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    2009
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    $ 33.54万
  • 项目类别:
    Grant-in-Aid for Young Scientists (B)
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