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Non-canonical olfactory and vomeronasal receptors

非典型嗅觉和犁鼻受体

基本信息

批准号：
8472473
负责人：
STEPHEN Daniel LIBERLES
金额：
$ 38.58万
依托单位：
HARVARD MEDICAL SCHOOL
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-07-01 至 2014-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8472473
关键词：
Afferent Neurons Age Agonist Amines Anabolism Animals Behavior Behavior Control Biological Factors Biological Models Brain Chemicals Cognition Disorders Color Cues Data Diet Emotional disorder Esthesia Eubacterium Evolution Family Functional disorder G-Protein-Coupled Receptors Gender Health Human Immune response Immune system In Situ Hybridization Individuality Instinct Ligands Mammals Mitochondria Molecular Mus Nasal cavity Neurons Nose Odors Olfactory Epithelium Partner in relationship Peptide Library Peptides Perception Pheromone Play Rattus Reporting Rodent Role Sensory Sensory Receptors Signal Transduction Smell Perception Stimulus Structure System Techniques Testing Tissues Urine behavior influence combinatorial environmental chemical fMet-Leu-Phe receptor feeding fighting insight member neural circuit novel receptive field receptor receptor function research study response social urinary vomeronasal organ

项目摘要

Project Summary Olfactory neural circuits generate tens of thousands of distinct perceptions and influence innate behaviors, such as feeding, and in many mammals, pheromone responses such as fighting and mating. Mammals have two principal olfactory tissues: the main olfactory epithelium and the vomeronasal organ, each of which contains large families of dedicated sensory receptors and activates distinct neuronal circuits. We recently identified two non-canonical families of mammalian chemosensory receptors that are distinct from previously described odorant and vomeronasal receptors. In this proposal, we aim to understand the evolution, cellular organization, and chemoreceptive fields of these novel sensory receptors, to provide additional insight into the molecular mechanisms that underlie olfaction in mammals.

项目摘要嗅觉神经回路产生数以万计的不同感知和影响先天行为，如进食，在许多哺乳动物中，信息素反应，战斗和交配哺乳动物有两种主要的嗅觉组织：上皮和犁鼻器，其中每一个包含大的家庭，专门的感觉受体并激活不同的神经元回路。我们最近确定了两个非典型的哺乳动物化学感受器家族，不同于先前描述的气味和犁鼻受体。在这项提案中，我们的目标是了解进化，细胞组织，和化学感受野，这些新的感觉受体，以提供更多的了解分子哺乳动物嗅觉的基本机制。

项目成果

期刊论文数量（2）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Agonists for 13 trace amine-associated receptors provide insight into the molecular basis of odor selectivity.

DOI：
10.1021/cb300111e
发表时间：
2012-07-20
期刊：
ACS CHEMICAL BIOLOGY
影响因子：
4
作者：
Ferrero, David M.;Wacker, Daniel;Roque, Miguel A.;Baldwin, Maude W.;Stevens, Raymond C.;Liberles, Stephen D.
通讯作者：
Liberles, Stephen D.