Genetic and Psychosocial Predictors of Blood Pressure and Body Mass Index

血压和体重指数的遗传和社会心理预测因素

• 批准号: 8617892
• 负责人: Sharon L Kardia
• 金额: $ 14万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-30 至 2015-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8617892
• 关键词: Adult; African American; Age; Biological; Blood Pressure; Body mass index; Chromosomes; Chronic Disease; Cohort Studies; Complex; Consensus; Data; Dietary intake; Disadvantaged; Documentation; Economics; Elderly; Environment; Ethnic Origin; Ethnic group; Etiology; Genes; Genetic; Genomics; Health; Health behavior; Heritability; Hispanics; Hypertension; Income; Individual; Lead; Life; Link; Measures; Mediating; Methods; Molecular; Neighborhoods; Neurosecretory Systems; Not Hispanic or Latino; Obesity; Outcome; Pathway interactions; Personal Satisfaction; Phenotype; Physical activity; Plant Roots; Population; Psychosocial Factor; Race; Research; Respondent; Retirement; Risk Factors; Role; Sample Size; Sampling; Single Nucleotide Polymorphism; Social Characteristics; Socioeconomic Status; Stress; Surveys; Variant; Work; base; cohort; database of Genotypes and Phenotypes; disability; falls; gene environment interaction; genome-wide; health disparity; low socioeconomic status; novel; physical conditioning; psychosocial; racial and ethnic disparities; social; socioeconomics; trait

DESCRIPTION (provided by applicant): There is an emerging consensus that individual health outcomes are a result of multiple factors that range from biological to societal and that the proper understanding and quantification of the etiologic roles of genes and environments in the causation of diseases will require consideration of gene by environment interactions. However, traditional approaches to understanding the causes of individual health outcomes remain fragmented into "biological" and "social" approaches. Just as this paradigm often falls short in adequately explaining the causes for individual health outcomes, it also fails to adequately explain disparities in health outcomes at the population level. Despite the repeated documentation of racial and ethnic disparities in hypertension and obesity there is still substantial debate about their root causes. Identifying the range of factors that lead to the persistent and pronounced differences in the blood pressures and/or body mass index (BMI) of populations is critical for developing effective strategies for reducing these disparities. The Health Retirement Study (HRS) is a key cohort in which to conduct research at the intersection of the biological and social since it is a nationally- representative longitudinal panel study of oer 26,000 adults over age 50 (surveyed every two years). The rich combination of the blood pressure and BMI measures along with genomic data in the HRS presents an important opportunity to investigate the contribution of genetic, socioeconomic, and psychosocial factors to blood pressure and BMI in a large cohort study to accomplish the following specific aims: Aim 1: Estimate molecular-based heritability of blood pressure and body mass index (BMI) in a multi-ethnic cohort of nearly 16,000 older adults from the Health and Retirement Study. Aim 2: Investigate the gene-level and SNP-level associations of 60 gene regions that have significant and replicated evidence of association with blood pressure and BMI. Aim 3: Investigate socioeconomic status and psychosocial factors as modifiers of the molecular-based heritability, gene-level associations, and SNP-level associations with blood pressure and BMI.

描述（由申请人提供）：目前正在形成一种共识，即个体健康结局是从生物学到社会学的多种因素的结果，正确理解和量化基因和环境在疾病病因中的病因作用将需要考虑基因与环境的相互作用。然而，理解个人健康结果原因的传统方法仍然分为“生物”和“社会”方法。正如这一范式往往福尔斯不足以充分解释个人健康结果的原因一样，它也不能充分解释人口一级健康结果的差异。尽管反复记录了高血压和肥胖症的种族和民族差异，但对其根源仍存在实质性辩论。确定导致人群血压和/或体重指数（BMI）持续和显著差异的因素范围对于制定减少这些差异的有效策略至关重要。健康退休研究（HRS）是一项关键的队列研究，在其中进行生物学和社会学的交叉研究，因为它是一项具有全国代表性的纵向小组研究，涉及26，000多名50岁以上的成年人（每两年调查一次）。HRS中血压和BMI测量值与基因组数据沿着的丰富组合为在大型队列研究中研究遗传、社会经济和心理社会因素对血压和BMI的影响提供了重要机会，以实现以下特定目标：目标1：在来自健康和退休研究的近16，000名老年人的多种族队列中估计血压和体重指数（BMI）的分子遗传性。目标二：研究60个基因区域的基因水平和SNP水平的关联，这些基因区域具有与血压和BMI相关的显著和重复证据。目标三：调查社会经济状况和心理社会因素作为基于分子的遗传性、基因水平关联和SNP水平关联与血压和BMI的修饰因子。