Harmonized Diagnostic Assessment of Dementia (DAD) for Longitudinal Aging Study in India (LASI) Genomic Study-Covid-19 Administrative Supplement Year 2

印度纵向衰老研究 (LASI) 基因组研究的痴呆症统一诊断评估 (DAD) - Covid-19 行政补充第 2 年

• 批准号: 10309409
• 负责人: Sharon L Kardia
• 金额: $ 40.64万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-15 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10309409
• 关键词: Administrative Supplement; Aging; Attitude; Behavior; COVID-19; COVID-19 pandemic; COVID-19 vaccination; Cognition; Cognitive; Communities; Computer Assisted; Consumption; Country; Data; Data Set; Dementia; Diagnostic; Economic Policy; Economics; Elderly; Environment; Genomics; Genotype; Goals; Health; Health and Retirement Study; Health system; Household; Income; India; Intervention; Knowledge; Life Cycle Stages; Link; Long-Term Effects; Longitudinal Studies; Longitudinal Surveys; Low Income Population; Monitor; Mutation; Perception; Phenotype; Policies; Population Density; Protocols documentation; Recovery; Research; Research Personnel; Respondent; Risk; Sampling; Social Environment; Surveys; Symptoms; Telephone; Telephone Interviews; Time; United States; Work; avoidance behavior; burden of illness; cognitive testing; dementia risk; design; genome sequencing; health care availability; health care service utilization; innovation; interest; member; pandemic disease; social; social group; social relationships; social structure; social vulnerability; web site; welfare; whole genome

Project Summary The COVID-19 pandemic poses grave risks to countries across the globe. India may be particularly vulnerable as it has relatively weak health systems, high population density, a growing non-communicable disease burden, and a large low-income population. Since May 2020, we have developed and administered a bi- monthly phone survey which will continue over the course of 12 months, tracking the knowledge of and attitude toward COVID-19, as well as monitoring changes in the respondents’ health, cognition, health care utilization, and household income and consumption, for a large subsample of the Harmonized Diagnostic Assessment of Dementia for the Longitudinal Aging Study in India. The Harmonized Diagnostic Assessment of Dementia for the Longitudinal Aging Study in India (LASI-DAD) is the first and only nationally representative and publicly available dataset on late-life cognition and dementia in India. It administers the Harmonized Cognitive Assessment Protocol (HCAP) that is designed to be harmonized with ongoing longitudinal studies of aging around the world, including the Health and Retirement Study (HRS) in the United States and prior studies in India. This rich set of cognitive phenotypes and a variety of other health and social environment phenotypes, as well as genotype data from whole genome sequencing, give us a unique opportunity to identify the mutational spectrum underlying the risk of dementia and AD in a representative sample in India. In this application, we aim to conduct two additional rounds of phone surveys over the following 12-month period after the conclusion of the current one-year period to capture longer term effects of the COVID pandemic. The pandemic has influenced everyday lives, and it is likely that these effects may be sustained in the longer term. In order to capture such prolonged effects, we aim to collect two additional rounds of data over a 12-month time period. Leveraging the first wave of LASI-DAD, we will then investigate how COVID-19- related changes in the social, economic, and policy environments differentially impact the respondents’ health, particularly cognition and dementia. We will also aim to release data to the wider research community so all interested researchers will have access to eight rounds of rich, nationally representative panel data throughout and after the pandemic.

项目摘要 COVID-19疫情对地球仪各国构成严重风险。印度可能特别脆弱 由于其卫生系统相对薄弱、人口密度高、非传染性疾病日益严重， #21453;，以及大量低收入人口。自2020年5月以来，我们制定并管理了一个双- 每月电话调查，将持续12个月，跟踪知识和态度 对COVID-19的反应，以及监测受访者的健康，认知，医疗保健利用， 和家庭收入和消费，对一个大的子样本的统一诊断评估， 印度老年痴呆症纵向研究。 印度纵向老龄化研究中痴呆症的统一诊断评估（LASI-DAD） 是第一个也是唯一一个关于晚年认知和痴呆症的全国代表性和公开数据集 在印度它管理协调认知评估协议（HCAP），旨在 与世界各地正在进行的老龄化纵向研究相协调，包括健康和退休 美国的研究（HRS）和印度的既往研究。这种丰富的认知表型和各种 其他健康和社会环境表型，以及来自全基因组测序的基因型数据， 这为我们提供了一个独特的机会来确定痴呆和AD风险背后的突变谱， 印度的代表性样本。 在这项申请中，我们的目标是在接下来的12个月内进行另外两轮电话调查 于本一年期间结束后之期间内，以捕捉COVID之较长期影响 流行病这一流行病影响了日常生活，这些影响可能会持续到2010年。 更长远的计划为了捕捉这种长期影响，我们的目标是收集两轮额外的数据， 12个月的时间。利用LASI-DAD的第一波，我们将研究COVID-19- 社会、经济和政策环境的相关变化对受访者的健康产生不同的影响， 尤其是认知和痴呆症。我们还将致力于向更广泛的研究界发布数据， 感兴趣的研究人员将有机会获得八轮丰富的，全国代表性的面板数据， 在大流行之后。