Harmonized Diagnostic Assessment of Dementia (DAD) for Longitudinal Aging Study in India (LASI) Genomic Study-Covid-19 Administrative Supplement Year 2

印度纵向衰老研究 (LASI) 基因组研究的痴呆症统一诊断评估 (DAD) - Covid-19 行政补充第 2 年

• 批准号: 10309409
• 负责人: Sharon L Kardia
• 金额: $ 40.64万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-15 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10309409
• 关键词: Administrative Supplement; Aging; Attitude; Behavior; COVID-19; COVID-19 pandemic; COVID-19 vaccination; Cognition; Cognitive; Communities; Computer Assisted; Consumption; Country; Data; Data Set; Dementia; Diagnostic; Economic Policy; Economics; Elderly; Environment; Genomics; Genotype; Goals; Health; Health and Retirement Study; Health system; Household; Income; India; Intervention; Knowledge; Life Cycle Stages; Link; Long-Term Effects; Longitudinal Studies; Longitudinal Surveys; Low Income Population; Monitor; Mutation; Perception; Phenotype; Policies; Population Density; Protocols documentation; Recovery; Research; Research Personnel; Respondent; Risk; Sampling; Social Environment; Surveys; Symptoms; Telephone; Telephone Interviews; Time; United States; Work; avoidance behavior; burden of illness; cognitive testing; dementia risk; design; genome sequencing; health care availability; health care service utilization; innovation; interest; member; pandemic disease; social; social group; social relationships; social structure; social vulnerability; web site; welfare; whole genome

Project Summary The COVID-19 pandemic poses grave risks to countries across the globe. India may be particularly vulnerable as it has relatively weak health systems, high population density, a growing non-communicable disease burden, and a large low-income population. Since May 2020, we have developed and administered a bi- monthly phone survey which will continue over the course of 12 months, tracking the knowledge of and attitude toward COVID-19, as well as monitoring changes in the respondents’ health, cognition, health care utilization, and household income and consumption, for a large subsample of the Harmonized Diagnostic Assessment of Dementia for the Longitudinal Aging Study in India. The Harmonized Diagnostic Assessment of Dementia for the Longitudinal Aging Study in India (LASI-DAD) is the first and only nationally representative and publicly available dataset on late-life cognition and dementia in India. It administers the Harmonized Cognitive Assessment Protocol (HCAP) that is designed to be harmonized with ongoing longitudinal studies of aging around the world, including the Health and Retirement Study (HRS) in the United States and prior studies in India. This rich set of cognitive phenotypes and a variety of other health and social environment phenotypes, as well as genotype data from whole genome sequencing, give us a unique opportunity to identify the mutational spectrum underlying the risk of dementia and AD in a representative sample in India. In this application, we aim to conduct two additional rounds of phone surveys over the following 12-month period after the conclusion of the current one-year period to capture longer term effects of the COVID pandemic. The pandemic has influenced everyday lives, and it is likely that these effects may be sustained in the longer term. In order to capture such prolonged effects, we aim to collect two additional rounds of data over a 12-month time period. Leveraging the first wave of LASI-DAD, we will then investigate how COVID-19- related changes in the social, economic, and policy environments differentially impact the respondents’ health, particularly cognition and dementia. We will also aim to release data to the wider research community so all interested researchers will have access to eight rounds of rich, nationally representative panel data throughout and after the pandemic.

项目概要 COVID-19 大流行给全球各国带来了严重风险。印度可能特别脆弱 因为它的卫生系统相对薄弱、人口密度高、非传染性疾病日益严重 负担重，低收入人口众多。自 2020 年 5 月以来，我们制定并管理了双 每月电话调查将持续 12 个月，跟踪了解情况和态度 针对 COVID-19，以及监测受访者的健康、认知、医疗保健利用的变化， 以及家庭收入和消费，作为协调诊断评估的一个大子样本 印度纵向衰老研究的痴呆症。 印度纵向老龄化研究痴呆症统一诊断评估 (LASI-DAD) 是第一个也是唯一一个具有全国代表性且公开的晚年认知和痴呆症数据集 在印度。它管理协调认知评估协议 (HCAP)，该协议旨在 与世界各地正在进行的老龄化纵向研究相协调，包括健康和退休 在美国学习（HRS），之前在印度学习。这套丰富的认知表型和各种 其他健康和社会环境表型，以及来自全基因组测序的基因型数据， 为我们提供了一个独特的机会来识别痴呆症和AD风险背后的突变谱 印度的代表性样本。 在此应用程序中，我们的目标是在接下来的 12 个月内进行另外两轮电话调查 当前一年期结束后的一段时间，以捕捉新冠疫情的长期影响 大流行。大流行已经影响了日常生活，而且这些影响很可能会持续下去 长期来看。为了捕捉这种长期影响，我们的目标是收集另外两轮数据 12 个月的时间段。利用第一波 LASI-DAD，我们将研究 COVID-19 如何- 社会、经济和政策环境的相关变化对受访者的健康产生不同的影响， 特别是认知和痴呆。我们还将致力于向更广泛的研究界发布数据，以便所有 感兴趣的研究人员将在整个过程中获得八轮丰富的、具有全国代表性的小组数据 以及疫情过后。