Harmonized Diagnostic Assessment of Dementia (DAD) for Longitudinal Aging Study of India (LASI)-Genomic study

印度纵向衰老研究 (LASI) 的痴呆症统一诊断评估 (DAD) 基因组研究

基本信息

  • 批准号:
    10836795
  • 负责人:
  • 金额:
    $ 38.64万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2019
  • 资助国家:
    美国
  • 起止时间:
    2019-09-15 至 2024-08-31
  • 项目状态:
    已结题

项目摘要

Summary Genetic factors play an important role in Alzheimer’s disease (AD), and there is evidence that genes may play a bigger role in cognition as we age. Our preliminary analysis of the whole genome sequences from LASI-DAD shows that our study has the most comprehensive survey of genetic variation in South Asia. Further, we have uncovered that like most non-Africans, South Asians have ~1-3% ancestry from archaic hominins––Neanderthals and Denisovans. Surveys of Eurasians have shown that this history has played a critical role in shaping the genetic and phenotypic variation in modern humans. For instance, archaic ancestry in Eurasians has impacted numerous traits ranging from skin pigmentation to high altitude adaptation, and response to SARS-CoV-2. However, most studies have focused on Europeans and East Asians, with very few genomes from other parts of the world. Further, no study has investigated the role of archaic ancestry in impacting the risk of Alzheimer’s disease or cognitive phenotypes. To fill this gap, we aim to investigate how archaic hominins (Neanderthal and Denisovan) ancestry impacts the risk of Alzheimer’s disease and cognitive phenotypes in modern humans using the large dataset of 2,700 samples from our LASI-DAD study. The LASI-DAD dataset contains 2,700 individuals from diverse ethnolinguistic groups in India, with extensive phenotype information for Alzheimer’s disease risk and cognitive phenotypes. The detailed genotype and phenotype information from the LASI-DAD dataset provides a unique opportunity to study the impact of Neanderthal, Denisovan and introgressed segments from other unknown hominins on the health of present-day individuals and uncover introgressed genes associated with Alzheimer's disease risk. Moreover, we are currently collecting more samples from additional regions and the study is a very timely project as we can collect more samples from specific groups to increase our power for genotype-phenotype analysis that show promising results. In this application, we propose the following specific aims: (1) to generate a map of archai introgression in modern humans; (2) to perform association analysis to study the association of Alzheimer’s disease risk and archaic ancestry; (3) to recruit samples from additional regions to maximize its potential for future population genomics study.
总结

项目成果

期刊论文数量(1)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Cohort Profile: Real-Time Insights of COVID-19 in India (RTI COVID-India).
  • DOI:
    10.1186/s12889-023-15084-1
  • 发表时间:
    2023-02-09
  • 期刊:
  • 影响因子:
    4.5
  • 作者:
  • 通讯作者:
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Sharon L Kardia其他文献

1093-146 The association of plasma homocysteine with coronary artery atherosclerosis is modified by conventional risk factors
  • DOI:
    10.1016/s0735-1097(04)91419-2
  • 发表时间:
    2004-03-03
  • 期刊:
  • 影响因子:
  • 作者:
    Itikhar J Kullo;Kent R Bailey;Lawrence F Bielak;Sharon L Kardia;Patrick F Sheedy;Patricia A Peyser;Stephen T Turner
  • 通讯作者:
    Stephen T Turner

Sharon L Kardia的其他文献

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{{ truncateString('Sharon L Kardia', 18)}}的其他基金

Harmonized Diagnostic Assessment of Dementia (DAD) for Longitudinal Aging Study in India (LASI) Genomic Study-Covid-19 Administrative Supplement Year 2
印度纵向衰老研究 (LASI) 基因组研究的痴呆症统一诊断评估 (DAD) - Covid-19 行政补充第 2 年
  • 批准号:
    10309409
  • 财政年份:
    2019
  • 资助金额:
    $ 38.64万
  • 项目类别:
Harmonized Diagnostic Assessment of Dementia (DAD) for Longitudinal Aging Study of India (LASI)-Genomic study.
印度纵向衰老研究 (LASI) 基因组研究的痴呆症统一诊断评估 (DAD)。
  • 批准号:
    10017825
  • 财政年份:
    2019
  • 资助金额:
    $ 38.64万
  • 项目类别:
Harmonized Diagnostic Assessment of Dementia (DAD) for Longitudinal Aging Study of India (LASI)-Genomic study.
印度纵向衰老研究 (LASI) 基因组研究的痴呆症统一诊断评估 (DAD)。
  • 批准号:
    10237323
  • 财政年份:
    2019
  • 资助金额:
    $ 38.64万
  • 项目类别:
Harmonized Diagnostic Assessment of Dementia (DAD) for Longitudinal Aging Study of India (LASI)-Genomic study.
印度纵向衰老研究 (LASI) 基因组研究的痴呆症统一诊断评估 (DAD)。
  • 批准号:
    10685990
  • 财政年份:
    2019
  • 资助金额:
    $ 38.64万
  • 项目类别:
Harmonized Diagnostic Assessment of Dementia (DAD) for Longitudinal Aging Study of India (LASI)-Genomic study.
印度纵向衰老研究 (LASI) 基因组研究的痴呆症统一诊断评估 (DAD)。
  • 批准号:
    10474359
  • 财政年份:
    2019
  • 资助金额:
    $ 38.64万
  • 项目类别:
Genetic Mechanisms of Arteriosclerosis in Hypertensive Sibships
高血压同胞动脉硬化的遗传机制
  • 批准号:
    8918019
  • 财政年份:
    2014
  • 资助金额:
    $ 38.64万
  • 项目类别:
Genetic Mechanisms of Arteriosclerosis in Hypertensive Sibships
高血压同胞动脉硬化的遗传机制
  • 批准号:
    9302511
  • 财政年份:
    2014
  • 资助金额:
    $ 38.64万
  • 项目类别:
Genetic Mechanisms of Arteriosclerosis in Hypertensive Sibships
高血压同胞动脉硬化的遗传机制
  • 批准号:
    8758883
  • 财政年份:
    2014
  • 资助金额:
    $ 38.64万
  • 项目类别:
Genetic and Psychosocial Predictors of Blood Pressure and Body Mass Index
血压和体重指数的遗传和社会心理预测因素
  • 批准号:
    8738570
  • 财政年份:
    2013
  • 资助金额:
    $ 38.64万
  • 项目类别:
Genetic and Psychosocial Predictors of Blood Pressure and Body Mass Index
血压和体重指数的遗传和社会心理预测因素
  • 批准号:
    8617892
  • 财政年份:
    2013
  • 资助金额:
    $ 38.64万
  • 项目类别:

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    10818088
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