Harmonized Diagnostic Assessment of Dementia (DAD) for Longitudinal Aging Study of India (LASI)-Genomic study
印度纵向衰老研究 (LASI) 的痴呆症统一诊断评估 (DAD) 基因组研究
基本信息
- 批准号:10836795
- 负责人:
- 金额:$ 38.64万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2019
- 资助国家:美国
- 起止时间:2019-09-15 至 2024-08-31
- 项目状态:已结题
- 来源:
- 关键词:2019-nCoVAdmixtureAgeAgingAltitudeAlzheimer&aposs DiseaseAlzheimer&aposs disease related dementiaAlzheimer&aposs disease riskArchitectureAsiaAsian populationCaliforniaCognitionCognitiveData SetDementiaDiagnosticEast AsianEuropeanFutureGenesGeneticGenetic VariationGenomeGenomicsGenotypeGeographic LocationsHaplotypesHealthHumanIndiaIndividualLinguisticsLinkMapsMethodsMichiganModernizationParentsPhenotypePlayPopulationPositioning AttributePostdoctoral FellowRecording of previous eventsResearch PersonnelRoleSamplingShapesSkin PigmentationSouth AsianSurveysUniversitiesVariantWorkexperiencegenomic datainsightlarge datasetspublic health relevancerecruitresponsetraitwhole genome
项目摘要
Summary
Genetic factors play an important role in Alzheimer’s disease (AD), and there is evidence
that genes may play a bigger role in cognition as we age. Our preliminary analysis of the whole
genome sequences from LASI-DAD shows that our study has the most comprehensive survey of
genetic variation in South Asia. Further, we have uncovered that like most non-Africans, South
Asians have ~1-3% ancestry from archaic hominins––Neanderthals and Denisovans. Surveys of
Eurasians have shown that this history has played a critical role in shaping the genetic and
phenotypic variation in modern humans. For instance, archaic ancestry in Eurasians has impacted
numerous traits ranging from skin pigmentation to high altitude adaptation, and response to
SARS-CoV-2. However, most studies have focused on Europeans and East Asians, with very few
genomes from other parts of the world. Further, no study has investigated the role of archaic
ancestry in impacting the risk of Alzheimer’s disease or cognitive phenotypes.
To fill this gap, we aim to investigate how archaic hominins (Neanderthal and Denisovan)
ancestry impacts the risk of Alzheimer’s disease and cognitive phenotypes in modern humans
using the large dataset of 2,700 samples from our LASI-DAD study. The LASI-DAD dataset
contains 2,700 individuals from diverse ethnolinguistic groups in India, with extensive phenotype
information for Alzheimer’s disease risk and cognitive phenotypes. The detailed genotype and
phenotype information from the LASI-DAD dataset provides a unique opportunity to study the
impact of Neanderthal, Denisovan and introgressed segments from other unknown hominins on
the health of present-day individuals and uncover introgressed genes associated with Alzheimer's
disease risk. Moreover, we are currently collecting more samples from additional regions and the
study is a very timely project as we can collect more samples from specific groups to increase our
power for genotype-phenotype analysis that show promising results.
In this application, we propose the following specific aims: (1) to generate a map of archai
introgression in modern humans; (2) to perform association analysis to study the association of
Alzheimer’s disease risk and archaic ancestry; (3) to recruit samples from additional regions to
maximize its potential for future population genomics study.
摘要
遗传因素在阿尔茨海默病(AD)中起着重要作用,有证据表明
随着年龄的增长,基因可能会在认知方面发挥更大的作用。我们对整体的初步分析
来自LASI-DAD的基因组序列表明,我们的研究拥有最全面的
南亚的遗传变异。此外,我们还发现,像大多数非非洲人一样,南非
亚洲人有大约1-3%的远古人类祖先--尼安德特人和丹尼索瓦人。调查:
欧亚人已经表明,这段历史在塑造人类的基因和
现代人的表型变异。例如,欧亚大陆的古老祖先影响了
从皮肤色素沉着到高原适应的众多特征,以及对
SARS-CoV-2。然而,大多数研究都集中在欧洲人和东亚人身上,很少有
来自世界其他地区的基因组。此外,还没有研究调查古生词的作用
影响阿尔茨海默病风险或认知表型的祖先。
为了填补这一空白,我们的目标是研究古人类(尼安德特人和丹尼索万人)如何
血统影响现代人患阿尔茨海默病的风险和认知表型
使用来自LASI-DAD研究的2700个样本的大型数据集。LASI-DAD数据集
包含来自印度不同民族语言群体的2700人,具有广泛的表型
有关阿尔茨海默病风险和认知表型的信息。详细的基因分型和
来自LASI-DAD数据集的表型信息为研究
尼安德特人、丹尼索瓦人和其他未知人种的导入片段对人类的影响
现代个体的健康和发现与阿尔茨海默氏症相关的导入基因
疾病风险。此外,我们目前正从更多地区收集更多样本,
研究是一个非常及时的项目,因为我们可以从特定的群体中收集更多的样本来增加我们的
显示出有希望的结果的基因型-表型分析的能力。
在本申请中,我们提出了以下具体目标:(1)生成古生物地图
(2)进行关联分析,研究人与人的关系
阿尔茨海默氏症的风险和古老的祖先;(3)从更多地区招募样本以
最大限度地发挥其在未来群体基因组学研究中的潜力。
项目成果
期刊论文数量(1)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Cohort Profile: Real-Time Insights of COVID-19 in India (RTI COVID-India).
- DOI:10.1186/s12889-023-15084-1
- 发表时间:2023-02-09
- 期刊:
- 影响因子:4.5
- 作者:
- 通讯作者:
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Sharon L Kardia其他文献
1093-146 The association of plasma homocysteine with coronary artery atherosclerosis is modified by conventional risk factors
- DOI:
10.1016/s0735-1097(04)91419-2 - 发表时间:
2004-03-03 - 期刊:
- 影响因子:
- 作者:
Itikhar J Kullo;Kent R Bailey;Lawrence F Bielak;Sharon L Kardia;Patrick F Sheedy;Patricia A Peyser;Stephen T Turner - 通讯作者:
Stephen T Turner
Sharon L Kardia的其他文献
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{{ truncateString('Sharon L Kardia', 18)}}的其他基金
Harmonized Diagnostic Assessment of Dementia (DAD) for Longitudinal Aging Study of India (LASI)-Genomic study.
印度纵向衰老研究 (LASI) 基因组研究的痴呆症统一诊断评估 (DAD)。
- 批准号:
10017825 - 财政年份:2019
- 资助金额:
$ 38.64万 - 项目类别:
Harmonized Diagnostic Assessment of Dementia (DAD) for Longitudinal Aging Study in India (LASI) Genomic Study-Covid-19 Administrative Supplement Year 2
印度纵向衰老研究 (LASI) 基因组研究的痴呆症统一诊断评估 (DAD) - Covid-19 行政补充第 2 年
- 批准号:
10309409 - 财政年份:2019
- 资助金额:
$ 38.64万 - 项目类别:
Harmonized Diagnostic Assessment of Dementia (DAD) for Longitudinal Aging Study of India (LASI)-Genomic study.
印度纵向衰老研究 (LASI) 基因组研究的痴呆症统一诊断评估 (DAD)。
- 批准号:
10237323 - 财政年份:2019
- 资助金额:
$ 38.64万 - 项目类别:
Harmonized Diagnostic Assessment of Dementia (DAD) for Longitudinal Aging Study of India (LASI)-Genomic study.
印度纵向衰老研究 (LASI) 基因组研究的痴呆症统一诊断评估 (DAD)。
- 批准号:
10685990 - 财政年份:2019
- 资助金额:
$ 38.64万 - 项目类别:
Harmonized Diagnostic Assessment of Dementia (DAD) for Longitudinal Aging Study of India (LASI)-Genomic study.
印度纵向衰老研究 (LASI) 基因组研究的痴呆症统一诊断评估 (DAD)。
- 批准号:
10474359 - 财政年份:2019
- 资助金额:
$ 38.64万 - 项目类别:
Genetic Mechanisms of Arteriosclerosis in Hypertensive Sibships
高血压同胞动脉硬化的遗传机制
- 批准号:
8918019 - 财政年份:2014
- 资助金额:
$ 38.64万 - 项目类别:
Genetic Mechanisms of Arteriosclerosis in Hypertensive Sibships
高血压同胞动脉硬化的遗传机制
- 批准号:
9302511 - 财政年份:2014
- 资助金额:
$ 38.64万 - 项目类别:
Genetic Mechanisms of Arteriosclerosis in Hypertensive Sibships
高血压同胞动脉硬化的遗传机制
- 批准号:
8758883 - 财政年份:2014
- 资助金额:
$ 38.64万 - 项目类别:
Genetic and Psychosocial Predictors of Blood Pressure and Body Mass Index
血压和体重指数的遗传和社会心理预测因素
- 批准号:
8738570 - 财政年份:2013
- 资助金额:
$ 38.64万 - 项目类别:
Genetic and Psychosocial Predictors of Blood Pressure and Body Mass Index
血压和体重指数的遗传和社会心理预测因素
- 批准号:
8617892 - 财政年份:2013
- 资助金额:
$ 38.64万 - 项目类别:
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