Sarcoidosis and A1AT Genomics & Informatics Center
结节病和 A1AT 基因组学
基本信息
- 批准号:8464244
- 负责人:
- 金额:$ 362.82万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2012
- 资助国家:美国
- 起止时间:2012-05-01 至 2015-11-30
- 项目状态:已结题
- 来源:
- 关键词:AddressAffectBioinformaticsBiological MarkersBiopsyBloodBlood VesselsCharacteristicsChronic Obstructive Airway DiseaseChronic lung diseaseClinicalClinical ProtocolsClinical ResearchClinical SciencesCollectionCommunicable DiseasesCommunitiesComplexComputational BiologyDataData AnalysesData SetDepositionDevelopmentDiseaseDisease ProgressionEnvironmentEpidemiologyEtiologyGene ExpressionGene Expression ProfileGenomeGenomicsGranulomaHealthHereditary DiseaseHumanImmuneInflammationInformaticsInstitutesInterventionLiverLungLung diseasesMalignant NeoplasmsMapsMedicineMessenger RNAMetagenomicsMicroRNAsMolecularMolecular ProfilingMorbidity - disease rateNational Heart, Lung, and Blood InstituteNatureOrganOrganismOutcomePathologyPatient RecruitmentsPatientsPatternPerceptionPerformancePeripheral Blood Mononuclear CellPharmaceutical PreparationsPhenotypePopulationPreparationProcessProteomicsProtocols documentationPulmonary SarcoidosisRadiology SpecialtyRegulationReproducibilityResearchResearch Project GrantsResourcesRiskSamplingSarcoidosisSeveritiesSeverity of illnessSkinSputumSterilitySystemic diseaseTechnologyTissuesTranscriptTranslational ResearchUniversitiesViralalpha 1-Antitrypsinalpha 1-Antitrypsin Deficiencybasecell typeclinical phenotypecostdata integrationdata managementdesigndisease classificationdisease phenotypehigh throughput technologyimprovedinsightlymph nodesmetagenomemicrobial communitymicrobiomemicroorganismmolecular phenotypenovelparticleprogramsrepositorystatisticstranscriptomics
项目摘要
DESCRIPTION (provided by applicant):
Alpha-1 antitrypsin deficiency (A1 AT), an autosomal recessive genetic disease that is associated with a variable risk of COPD, and Sarcoidosis, a systemic disease characterized by the formation of granulomatous lesions especially In the lungs, liver, skin, and lymph nodes that leads to a dramatically heterogeneous set of clinical manifestations, differ in etiology and clinicl presentation but share a variable and unpredictable course. To improve disease classification, facilitate biomarker discovery and accelerate advent of novel therapy an integrative approach that combines the results of clinical studies with molecular phenotyping results is required. The Sarcoidosis and A1 AT Genomics and Informatics Center (SAGIC) will facilitate this process by addressing the following objectives for the NHLBI Genomic Research In A1 AT and Sarcoidosis (GRADS) program: 1) Coordination of Clinical Centers activities that include patient recruitment and phenotyping and biospecimen collection. 2) Performance of transcriptome and microbiome analyses of the samples obtained by the Clinical Centers, 3) Data analysis and integration, 4) Dataset preparation for deposit in the NHLBI BloLINCC repository. The objectives will be addressed through two research projects. Project 1: A1 AT microbiome - will address the hypothesis that shifts in the lung microbiome determine the extent of lung involvement In A1 AT and that they are reflected in mRNA and microRNA changes in surrogate tissues, and Project 2: Novel molecular phenotypes in Sarcoidosis - will address the hypothesis that systemic Inflammation as reflected in gene expression changes in PBMC Is indicative of disease extent, microbiome shifts and granuloma molecular networks.
描述(由申请人提供):
α-1抗胰蛋白酶缺乏症(A1 AT),一种常染色体隐性遗传疾病,与COPD的可变风险相关,以及结节病,一种全身性疾病,其特征在于肉芽肿性病变的形成,特别是在肺、肝、皮肤和淋巴结中,导致一组显著异质的临床表现,在病因学和临床表现上不同,但具有可变和不可预测的病程。为了改善疾病分类,促进生物标志物的发现和加速新疗法的出现,需要将临床研究结果与分子表型结果相结合的综合方法。结节病和A1 AT基因组学和信息学中心(SAGIC)将通过解决NHLBI A1 AT和结节病基因组研究(GRADS)计划的以下目标来促进这一过程:1)协调临床中心活动,包括患者招募和表型分析以及生物标本收集。2)对临床中心获得的样本进行转录组和微生物组分析,3)数据分析和整合,4)准备数据集以存款NHLBI BloLINCC存储库。这些目标将通过两个研究项目来实现。项目一:A1 AT微生物组-将解决以下假设:肺微生物组的变化决定A1 AT中肺受累的程度,并且它们反映在替代组织中的mRNA和microRNA变化中,以及项目2:结节病中的新分子表型-将解决PBMC中基因表达变化所反映的全身性炎症指示疾病程度的假设,微生物组变化和肉芽肿分子网络。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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MICHAEL JOHN BECICH其他文献
MICHAEL JOHN BECICH的其他文献
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{{ truncateString('MICHAEL JOHN BECICH', 18)}}的其他基金
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- 批准号:
10376944 - 财政年份:2021
- 资助金额:
$ 362.82万 - 项目类别:
Continuation and Expansion of the National Mesothelioma Virtual Bank for Translational Research (U24) - 2021
国家间皮瘤转化研究虚拟银行 (U24) 的延续和扩展 - 2021
- 批准号:
10650211 - 财政年份:2021
- 资助金额:
$ 362.82万 - 项目类别:
National Mesothelioma Virtual Bank, Continued Innovation
国家间皮瘤虚拟银行,持续创新
- 批准号:
9340126 - 财政年份:2016
- 资助金额:
$ 362.82万 - 项目类别:
National Mesothelioma Virtual Bank, Continued Innovation
国家间皮瘤虚拟银行,持续创新
- 批准号:
9419494 - 财政年份:2016
- 资助金额:
$ 362.82万 - 项目类别:
National Mesothelioma Virtual Bank, Continued Innovation
国家间皮瘤虚拟银行,持续创新
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9244884 - 财政年份:2016
- 资助金额:
$ 362.82万 - 项目类别:
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9324915 - 财政年份:2013
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$ 362.82万 - 项目类别:
Sarcoidosis and A1AT Genomics & Informatics Center
结节病和 A1AT 基因组学
- 批准号:
8918136 - 财政年份:2012
- 资助金额:
$ 362.82万 - 项目类别:
Sarcoidosis and A1AT Genomics & Informatics Center
结节病和 A1AT 基因组学
- 批准号:
8265053 - 财政年份:2012
- 资助金额:
$ 362.82万 - 项目类别:
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