Continuation and Expansion of the National Mesothelioma Virtual Bank for Translational Research (U24) - 2021

国家间皮瘤转化研究虚拟银行 (U24) 的延续和扩展 - 2021

• 批准号: 10650211
• 负责人: MICHAEL JOHN BECICH
• 金额: $ 107.92万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-01 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10650211
• 关键词: Continuation; Expansion; National; Mesothelioma; Virtual

Summary: The National Mesothelioma Virtual Bank (NMVB) network consents patients to provide biospecimens (blood products and tissue) together with demographic data, occupational history and clinical data (stage, treatment and survival information) to the mesothelioma research community. In addition, protein biomarkers, genomic and imaging data are also collected by researchers and shared for future studies. The University of Pittsburgh is the coordinating site for the NMVB protocol, which is also in place at four partnering sites, New York University, Roswell Park Comprehensive Cancer Center, University of Maryland and University of Pennsylvania. Our specific aims are to: 1) Continue to serve the mesothelioma cancer research community by collecting and distributing tissue, blood and the aforementioned data as well as increasing the NMVB cohort to 2200 patients. We will continue to document and continually evaluate the usefulness of the NMVB to the scientific community and measure its impact in collaboration with the Mesothelioma Applied Research Foundation; 2) Expand the network to the Baylor College of Medicine which increases both the geographic and racial diversity of the NMVB cohort. We will also promote our mesothelioma data model nationally and internationally to encourage linkage to other registries; and 3) Our continued innovation aim is to automate annotation of biospecimens through extraction of clinical, outcomes, and pathology data from electronic health records and cancer registry systems through a cost-effective open source tool for Research Electronic Data Capture or REDCap. We will deploy and implement scalable, cost-effective tools to maximize the effectiveness of the data extraction process across collaborating sites which will allow linkage to other national and international tissue and data sharing networks.

摘要： 国家间皮瘤虚拟银行(NMVB)网络同意患者提供生物标本(血液 产品和组织)以及人口统计数据、职业史和临床数据(分期、治疗 和生存信息)提供给间皮瘤研究社区。此外，蛋白质生物标记物、基因组 成像数据也由研究人员收集并分享，以供未来研究。匹兹堡大学 NMVB协议的协调站点，也在纽约的四个合作站点 美国马里兰大学罗斯威尔公园综合癌症中心 宾夕法尼亚州。我们的具体目标是：1)继续通过以下方式为间皮瘤癌症研究社区服务 收集和分发组织、血液和上述数据，并将NMVB队列增加到 2200名患者。我们将继续记录并持续评估NMVB对 科学界与间皮瘤应用研究合作衡量其影响 基金会；2)将网络扩展到贝勒医学院，从而增加了地理和 NMVB队列的种族多样性。我们还将在全国推广我们的间皮瘤数据模型 在国际上鼓励与其他注册处的联系；以及3)我们的持续创新目标是实现自动化 通过从电子健康中提取临床、结果和病理数据对生物样本进行注释 通过具有成本效益的研究电子数据开放源码工具建立病历和癌症登记系统 俘虏或红帽。我们将部署和实施可扩展、经济高效的工具，以最大限度地提高效率 跨协作站点的数据提取过程，这将允许链接到其他国家和 国际组织和数据共享网络。