University of Miami Developmental Center for AIDS Research (D-CFAR)

简介（由申请人提供）：迈阿密大学米勒医学院拟设立艾滋病研究发展中心（UM D-CFAR）。UM D-CFAR的目标是成功地发展成为一个完整的CFAR，并履行美国国立卫生研究院声明的CFAR使命，“支持一个多学科的环境，促进艾滋病毒感染和艾滋病的预防、检测和治疗方面的基础、临床、流行病学、行为和转化研究。”UM D-CFAR将利用其优势为NIH资助的研究活动提供基础设施，并促进旨在实现D-CFAR使命的新研究。总体领导将由Savita Pahwa博士提供，他在艾滋病毒/艾滋病领域的临床和实验室研究方面拥有丰富的经验。她将由Margaret Fischl博士协助，她将指导各种临床方面和并发症的研究。Pahwa博士将领导行政核心，以确保核心和科学研究领域之间的跨学科互动。发展核心小组将由格温多林·斯科特博士领导，盖尔·肖尔-波斯纳博士协助。他们将促进指导、新的研究活动和国际培训。已选择的“共享内核”为“1”。临床科学核心：该核心将由Margaret Fischl博士领导，并将为D-CFAR成员提供生物统计学支持和生物库管理。她还将在特殊队列发展和患者安全相关问题上提供专业知识。2. 实验室科学核心将由Savita Pahwa博士领导，Andreas Baur博士协助。该核心将提供广泛的免疫学和病毒学检测，从常规到专业，高级和发展。此外，一个新颖的组成部分是介绍资源的神经艾滋病的研究。3. 行为/社会科学和社区外展核心（BSSCO）核心将由博士领导。丽莎·梅奇和尼尔·施奈德曼。BSSCO核心将把其资源和专门知识用于加强当前的行为和社会科学艾滋病毒/艾滋病研究，并促进行为/社会科学、临床和基础科学研究人员之间更好的联系。BSSCO核心还将领导D-CFAR通过我们的D-CFAR社区咨询委员会开展和发展有意义的社区伙伴关系。在强有力的机构承诺和优秀的持续研究活动的支持下，我们有信心及时过渡到一个完整的CFAR。

DESCRIPTION (provided by applicant): The University of Miami, Miller School of Medicine proposes to establish a Developmental Center for AIDS Research (UM D-CFAR). The goal of the UM D-CFAR is to successfully develop into a full CFAR and fulfill the NIH stated CFAR mission "to support a multi-disciplinary environment that promotes basic, clinical, epidemiological, behavioral, and translational research in the prevention, detection, and treatment of HIV infection and AIDS." The UM D-CFAR will build on its strengths to provide the infrastructure for the NIH funded research activities and promote new research aimed at fulfilling the D-CFAR mission. The overall leadership will be provided by Dr. Savita Pahwa, who has extensive experience in clinical and laboratory research in the HIV/AIDS field. She will be assisted by Dr. Margaret Fischl, who will provide direction in various clinical aspects and complications research. Dr. Pahwa will head the Administrative Core to ensure inter-disciplinary interaction among cores and the scientific areas of research. The Developmental Core will be led by Dr Gwendolyn Scott, with assistance from Dr Gail Shor-Posner. They will promote mentoring, new research activities and international training. The shared Cores that have been selected are 1. Clinical Sciences Core: This core will be under the leadership of Dr Margaret Fischl and will offer biostatistical support and bio repository management for the D-CFAR members. She will also provide expertise in special cohort development and issues related to patient safety. 2. Laboratory Sciences Core will be led by Dr Savita Pahwa with assistance from Dr Andreas Baur. This Core will provide a broad range of assays in immunology and virology from routine to specialized, advanced and developmental. In addition a novel component is to introduce resources for Neuro-AIDS research. 3. The Behavioral/Social Sciences and Community Outreach Core (BSSCO) Core will be led by Drs. Lisa Metsch and Neil Schneiderman. The BSSCO Core will devotes its resources and expertise to enhance current behavioral and social science HIV/AIDS research and facilitate better linkages among behavioral/social science, clinical and basic science investigators. The BSSCO Core will also lead the D-CFAR in working and developing meaningful community partnerships through our D-CFAR community advisory board. Backed with a strong institutional commitment and with excellent ongoing research activities, we are confident of a timely transition into a full CFAR. CORE A: Administrative Core (Pahwa, Savita) CORE A DESCRIPTION (provided by applicant):The Administrative Core will provide the infrastructure that ties together and integrates the various components of the University of Miami CFAR (UM D-CFAR). The goal of the Core is to provide overall leadership, administrative support, financial and operational management, and planning functions for the UM D-CFAR. The specific aims of the administrative core are to insure the smooth operation and management of the center by providing the following services: 1) Administrative leadership and oversight and support for all the programs and cores. 2) Facilitation of communication and information dissemination and collaboration among UM D-CFAR researchers, institutional officials, the national D-CFAR community and external groups. 3) Coordination of the activities of all the D-CFAR advisory committees including the organization of annual External Advisory Board meeting. 4) Budgetary and fiscal management and personnel resources of the D-CFAR. 5) Assist D-CFAR Executive Committee in the implementation of changes in priorities and funding in response to ongoing project evaluation. Execution of policies and procedures that govern the D-CFAR. Management of the annual strategic planning process for the D-CFAR. 6) Assist the Developmental Core by supporting organization and implementation of program development activities. 7) Preparation of all Reports to NIH CFAR program staff. 8) Maintenance of records and preparation of reports, including the annual D-CFAR continuation application. The scientific and administrative leadership for the UM D-CFAR will be provided by Dr Savita Pahwa, the Prinicipal Investigator of this Core. She will be assisted by Dr Margaret Fischl for clinical therapeutics research. An Administrative team will be led by a UM D-CFAR Coordinator (Michelle Perez). The Administrative Core will seek advice from the External and Internal Advisory Committees and the Executive Committee, and will be assisted in the developmental grant review process by the Scientific Research Committee