Human Energy and Body Weight Regulation Core

人体能量和体重调节核心

• 批准号: 8741646
• 负责人: Kong Chen
• 金额: $ 36.98万
• 依托单位: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8741646
• 关键词: Adipose tissue; Adult; Basal metabolic rate; Biomechanics; Body Composition; Body Temperature; Body Weight; Cannabis Smoking; Cell physiology; Child; Chronic; Clinical; Clinical Nutrition; Clinical Research; Cohort Studies; Collaborations; Cross-Over Studies; Data Analyses; Disease; Dose; Double-Blind Method; Dual-Energy X-Ray Absorptiometry; Energy Intake; Energy Metabolism; European; Exercise stress test; Fasting; Fatigue; Fatty Liver; Food; Gait; Gender; Glucose Intolerance; Heart Rate; Human; Hyperinsulinism; Iceland; Immunity; Inborn Errors of Metabolism; Infection; Inpatients; Insulin; Insulin Resistance; International; Journals; Leptin; Life; Limb structure; Lipodystrophy; Manuscripts; Measurement; Metabolic; Modification; National Heart, Lung, and Blood Institute; National Institute of Drug Abuse; National Institute on Alcohol Abuse and Alcoholism; Netherlands; Obesity; Older Population; Outpatients; Overweight; Pancreas; Paper; Patients; Pattern; Phase; Phenotype; Physical activity; Physiology; Placebo Control; Population; Protocols documentation; Randomized; Regulation; Research; Research Design; Research Personnel; Rest; Rewards; Services; Sex Characteristics; Skeletal Muscle; Speed; Surveys; Techniques; United States National Institutes of Health; Visceral; Vitamin E; Walking; Withdrawal; Woman; analytical method; behavior test; chronic liver disease; experience; fitness; instrument; metabolic abnormality assessment; muscle form; non-alcoholic fatty liver; nutrition; programs; respiratory

New protocols started in FY13: 1. 13-DK-0057: Short Term Effects of Leptin Withdrawal or Initiation in Lipodystrophy Independent of Energy Intake. PI Rebecca Brown, MD. ClinicalTrials.gov Identifier: NCT01778556. 2. 13-DK-0136: A Phase 1b, Randomized, Double-Blind, Placebo-Controlled, Multiple Dose, 2-Period Crossover Study to Evaluate the Effect of RM-493 on Energy Expenditure in Obese Subjects. PI. Monica Skarulis, MD. ClinicalTrials.gov Identifier: NCT01867437. 3. 13-Dk-0013: Impact of Chronic Cold Exposure on Energy Metabolism in Humans. PI, Francesco Celi, MD. ClinicalTrials.gov Identifier: NCT01730105. 4. 13-DK-0002: Treatment for Non-Alcoholic Fatty Liver With Different Doses of Vitamin E. PI, Yaron Rotman, MD. ClinicalTrials.gov identifier: NCT01792115. 5. 13-DK-0142: The Physiology of Fatigue in Patients With Chronic Liver Disease. PI, Yaron Rotman, MD. ClinicalTrials.gov identifier: NCT01867385. 6. 13-HG-0053: The NIH Mini Study: Metabolism, Infection and Immunity in Inborn Errors of Metabolism. PI, Peter McGuire, MD. ClinicalTrials.gov Identifier: NCT01780168 Research highlights: 1. Our clinical support services include routine measurements of resting metabolic rate in patients that ranges from young children (12 months) in the Undiagnosed Disease Program (UDP) to severely obese patients. The experiences led to an invited review manuscript (European Journal of Clinical Nutrition) that I coauthored with Dr. Tricia Psato from the Clinical Center Department of Nutrition. We highlighted the advancements, rewards and challenges of the technique, and the precautions and interpretations that are often difficult in such clinical populations. 2. A long-term collaboration with Dr. Richard Cannon (NHLBI) in the Keep-the-Beat II Study led to one manuscript in the International Journal of Obesity, where we found that hyperinsulinemia in overweight or obese women was associated with increased extremity muscle mass, which was partially reversible with reduction in fasting insulin concentration, suggesting the stimulatory effects of insulin on skeletal muscle in the overweight and obese. 3. In a collaboration with researchers at NIDA and NIAAA in a sub-study nested in the protocol Study of the Phenotype of Overweight and Obese Adults (07-DK-0077), we found that, when compared to BMI-matched normal controls, chronic cannabis smoking was associated with visceral adiposity and adipose tissue insulin resistance but not with hepatic steatosis, insulin insensitivity, impaired pancreatic β-cell function, or glucose intolerance. 4. We have been collaborating with investigators inside and outside of the NIH in field research using accelerometers. It continues to result in manuscripts. The Iceland study cohort revealed that there were gender differences in accelerometer-associated physical activity, even after adjusting for the difference in walking speed, which suggests that there were biomechanical differences in gait patterns between genders in the older populations. The other paper, we used the objective accelerometer to validate a subjective physical activity survey in an older population in the Netherlands. Services rendered: energy expenditure by whole-room respiratory chambers (444), resting energy expenditure by metabolic carts (290), graded exercise tests (102), experimental food behavior tests (103), and body composition (274 DXA, 204 Bod Pod), all of which were significantly increased from FY12.

新协议于2013财年启动： 1. 13-DK-0057：不依赖于能量摄入的脂肪代谢障碍患者停用或开始使用瘦素的短期影响。PI丽贝卡布朗，医学博士。ClinicalTrials.gov标识符：NCT 01778556。 2. 13-DK-0136：一项评价RM-493对肥胖受试者能量消耗影响的Ib期、随机、双盲、安慰剂对照、多次给药、2阶段交叉研究。Pi. Monica Skarulis医学博士ClinicalTrials.gov标识符：NCT 01867437。 3. 13-Dk-0013：慢性寒冷暴露对人类能量代谢的影响。PI，Francesco Celi，医学博士。ClinicalTrials.gov标识符：NCT 01730105。 4. 13-DK-0002：用不同剂量的维生素E治疗非酒精性脂肪肝。PI，Yaron Rotman，医学博士。ClinicalTrials.gov标识符：NCT 01792115。 5. 13-DK-0142：慢性肝病患者的疲劳生理学。PI，Yaron Rotman，医学博士。ClinicalTrials.gov标识符：NCT 01867385。 6. 13-HG-0053：NIH小型研究：先天性代谢缺陷中的代谢、感染和免疫。PI，Peter McGuire，医学博士。 ClinicalTrials.gov标识符：NCT 01780168 研究重点： 1. 我们的临床支持服务包括对未确诊疾病计划（UDP）中的幼儿（12个月）到严重肥胖患者的静息代谢率进行常规测量。这些经历导致了我与临床中心营养系的Tricia Psato博士共同撰写的特邀评论手稿（欧洲临床营养学杂志）。我们强调了该技术的进步，奖励和挑战，以及在这些临床人群中通常很难的预防措施和解释。 2. 与Richard Cannon博士（NHLBI）在Keep-the-Beat II研究中的长期合作导致了《国际肥胖杂志》上的一篇论文，我们发现超重或肥胖女性的高胰岛素血症与肢体肌肉质量增加有关，这在空腹胰岛素浓度降低时部分可逆，表明胰岛素对超重和肥胖者骨骼肌的刺激作用。 3. 在与NIDA和NIAAA的研究人员合作进行的一项子研究中，嵌套在超重和肥胖成年人表型研究（07-DK-0077）中，我们发现，与BMI匹配的正常对照相比，长期吸食大麻与内脏肥胖和脂肪组织胰岛素抵抗有关，但与肝脂肪变性，胰岛素不敏感性，胰腺细胞功能受损或葡萄糖耐受不良无关。 4. 我们一直在与NIH内外的研究人员合作，使用加速度计进行实地研究。它继续导致手稿。冰岛的研究队列显示，即使在调整步行速度的差异之后，与加速度计相关的身体活动也存在性别差异，这表明老年人群中性别之间的步态模式存在生物力学差异。在另一篇论文中，我们使用客观加速度计来验证荷兰老年人群的主观身体活动调查。 提供的服务：全室呼吸室能量消耗（444）、代谢车静息能量消耗（290）、分级运动试验（102）、实验性食物行为试验（103）和身体成分（274 DXA，204 Bod Pod），所有这些都比2012财年显著增加。