Phenotyping studies related to energy balance and obesity

与能量平衡和肥胖相关的表型研究

• 批准号: 7734334
• 负责人: Kong Chen
• 金额: $ 31.91万
• 依托单位: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7734334
• 关键词: Agreement; Air; Area; Autonomic nervous system; Behavior; Behavioral; Biolectric Impedance; Bion; Blood; Blood Pressure; Blood Pressure Monitors; Body Composition; Body Temperature; Body Weight; Chronic; Clinical; Complex; Data; Discipline of Nuclear Medicine; Dual-Energy X-Ray Absorptiometry; Endocrinology; Energy Intake; Energy Metabolism; Environment; Equilibrium; Exercise; Genetic; Heart Rate; Homeostasis; Human; Individual; Individual Differences; Inpatients; Journals; Knowledge; Life; Link; Manuscripts; Measurement; Measures; Metabolic; Metabolism; Monitor; Nature; Neurocognitive; OGTT; Obesity; Outpatients; Patients; Phenotype; Physical Function; Physical activity; Physiology; Polysomnography; Protocols documentation; Psychology; Regulation; Reproducibility; Research; Rest; Scanning; Services; Skin; Skin Temperature; System; Taste Perception; Techniques; Testing; clinically relevant; energy balance; instrument; psychologic; respiratory; social

Services rendered: metabolic serial testing (FSIVGTT, OGTT, mixed-meal), 24-hr energy expenditure by whole-room respiratory chambers, resting energy expenditure, exercise and physical function testing, body composition, objective physical activity monitoring, core/skin temperature, heart rate/blood pressure variability, behavioral, psychological, and neurocognitive assessments, taste tests, sleep measurements In the area of body composition, we successfully validated our new instruments (large-scale dual-energy x-ray absorptiometry - DXA, air-displacement plethysmograph -BodPod, and bioelectrical impedance analyzers - BIA). We have shown excellent reproducibility of the DXA (>99%) and its validity for measuring obese patients using half-scans (manuscript accepted by Journal of Obesity). We also demonstrated the agreement between DXA, Bod Pod, and BIA in a heterogeneous group while showing between-individual differences. We also discovered a small but clinically relevant difference between our new DXA and the DXA scanner used by the Clinical Center Nuclear Medicine Department. This is important not only methodologically, but for comparing studies using different scanners. Similarly, we have successfully modified and validated other measurement techniques for the Metabolic Research Core, such as continuous heart-rate and blood pressure monitors for autonomic nervous system activity assessments, blood-draw isolette systems for the metabolic suites, skin and core body temperature monitors, and multiple portable physical activity monitors. Currently, we are supporting 20+ active protocols for various services, with focuses on producing comprehensive, accurate, and precise measurements of human metabolism. The integration of these measurements will help us understand the complex nature of energy homeostasis in healthy and diseased states.

提供的服务：代谢系列测试（FSIVGTT、OGTT、混合餐）、全室呼吸室24小时能量消耗、静息能量消耗、运动和身体功能测试、身体成分、客观身体活动监测、核心/皮肤温度、心率/血压变异性、行为、心理和神经认知评估、味觉测试、睡眠测量 在身体成分方面，我们成功验证了我们的新仪器（大型双能X射线吸收测量仪- DXA，空气置换体积描记仪-BodPod和生物电阻抗分析仪- BIA）。我们已经证明了DXA的良好再现性（>99%）及其使用半扫描测量肥胖患者的有效性（手稿被肥胖杂志接受）。我们还证明了DXA，BOD POD，BIA之间的协议在一个异质组，同时显示个体间的差异。我们还发现了我们的新DXA和临床中心核医学部使用的DXA扫描仪之间的一个小的但临床相关的差异。这不仅在方法学上很重要，而且对于使用不同扫描仪进行比较研究也很重要。 同样，我们已经成功地修改和验证了代谢研究核心的其他测量技术，例如用于自主神经系统活动评估的连续心率和血压监测器，用于代谢套件的抽血隔离系统，皮肤和核心体温监测器，以及多个便携式身体活动监测器。 目前，我们正在为各种服务提供20多种主动协议，重点是对人体代谢进行全面，准确和精确的测量。这些测量的整合将帮助我们理解健康和疾病状态下能量稳态的复杂性质。