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Metabolic Regulation of T cell Immunity

Metabolic Regulation of T cell Immunity
T 细胞免疫的代谢调节
批准号：
8517572
负责人：
Ananda W Goldrath
金额：
$36.43万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN DIEGO
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
项目状态：
已结题
起止时间：
2012-08-01 至 2016-07-31
来源：
https://reporter.nih.gov/project-details/8517572
关键词：
AcuteAddressAntigensApoptosisAttenuatedBacteriaCD8B1 geneCell Differentiation processCell SurvivalCell physiologyCellsCessation of lifeChronicColitisComplementComplexCuesCytotoxic T-LymphocytesDataDevelopmentDiabetes MellitusDiseaseEffector CellEnzymesEquilibriumExperimental ModelsExposure toFatty AcidsGene Expression ProfileGene Expression ProfilingGenerationsGlycolysisHomeostasisHypoxiaHypoxia Inducible FactorHypoxia-Inducible Factor PathwayImmune responseImmunityImmunologic MemoryImmunologic MonitoringImmunosuppressive AgentsIndividualInfectionKineticsLifeLinkMature T-LymphocyteMemoryMetabolicMetabolismMetforminMolecularMolecular TargetMonitorMusNutrientOxidative PhosphorylationOxygenOxygen measurement, partial pressure, arterialParasitesPathway interactionsPeripheralPharmaceutical PreparationsPhysiologicalPlayPopulationReportingResolutionRoleScanningSignal TransductionSirolimusT cell differentiationT cell regulationT cell responseT memory cellT-Cell ActivationT-LymphocyteTestingTissuesTranscendVHL mutationVariantVirusVon Hippel-Lindau Tumor Suppressor Proteinarmcytokinecytotoxicfatty acid metabolismhuman FRAP1 proteinhypoxia inducible factor 1in vivomembermouse modelpathogenprogramsresponsesecondary infectionubiquitin-protein ligase

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DESCRIPTION (provided by applicant): To generate a robust and effective immune response, T cells must integrate pathogen-derived and micro- environmental signals; these include availability of nutrients and oxygen. Together these signals regulate the metabolic changes necessary for the dramatic expansion of effector T cells armed to eliminate pathogens. We have found that a specific metabolic response pathway controls T cell immunity, and will identify the signaling and physiological parameters that link the metabolic activity of T cells during their response to pathogen with their differentiation and function. )
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Ubiquitin ligase regulation of tissue-resident T cell and anti-tumor activity
Regulation of memory T cell differentiation and long-term maintenance
  • 批准号：
    10683278
  • 项目类别：
  • 资助金额：
    $55.53万
  • 财政年份：
    2020
  • 负责人：
    Ananda W Goldrath
  • 依托单位：
    UNIVERSITY OF FLORIDA
Regulation of memory T cell differentiation and long-term maintenance
  • 批准号：
    10591871
  • 项目类别：
  • 资助金额：
    $12.34万
  • 财政年份：
    2020
  • 负责人：
    Ananda W Goldrath
  • 依托单位：
    UNIVERSITY OF FLORIDA
Regulation of memory T cell differentiation and long-term maintenance
  • 批准号：
    10024589
  • 项目类别：
  • 资助金额：
    $50.91万
  • 财政年份：
    2020
  • 负责人：
    Ananda W Goldrath
  • 依托单位：
    LA JOLLA INSTITUTE FOR IMMUNOLOGY
海外基金