Metabolic Regulation of T cell Immunity

T 细胞免疫的代谢调节

• 批准号: 8707349
• 负责人: Ananda W Goldrath
• 金额: $ 38.75万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-08-01 至 2016-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8707349
• 关键词: Acute; Address; Antigens; Apoptosis; Attenuated; Bacteria; CD8B1 gene; Cell Differentiation process; Cell Survival; Cell physiology; Cells; Cessation of life; Chronic; Colitis; Complement; Complex; Cues; Cytotoxic T-Lymphocytes; Data; Development; Diabetes Mellitus; Disease; Effector Cell; Enzymes; Equilibrium; Experimental Models; Exposure to; Fatty Acids; Gene Expression Profile; Gene Expression Profiling; Generations; Glycolysis; Homeostasis; Hypoxia; Hypoxia Inducible Factor; Hypoxia-Inducible Factor Pathway; Immune response; Immunity; Immunologic Memory; Immunologic Monitoring; Immunosuppressive Agents; Individual; Infection; Kinetics; Life; Link; Mature T-Lymphocyte; Memory; Metabolic; Metabolism; Metformin; Molecular; Molecular Target; Monitor; Mus; Nutrient; Oxidative Phosphorylation; Oxygen; Oxygen measurement, partial pressure, arterial; Parasites; Pathway interactions; Peripheral; Pharmaceutical Preparations; Physiological; Play; Population; Reporting; Resolution; Role; Scanning; Signal Transduction; Sirolimus; T cell differentiation; T cell regulation; T cell response; T memory cell; T-Cell Activation; T-Lymphocyte; Testing; Tissues; Transcend; VHL mutation; Variant; Virus; Von Hippel-Lindau Tumor Suppressor Protein; arm; cytokine; cytotoxic; fatty acid metabolism; human FRAP1 protein; hypoxia inducible factor 1; in vivo; member; mouse model; pathogen; programs; response; secondary infection; ubiquitin-protein ligase

DESCRIPTION (provided by applicant): To generate a robust and effective immune response, T cells must integrate pathogen-derived and micro- environmental signals; these include availability of nutrients and oxygen. Together these signals regulate the metabolic changes necessary for the dramatic expansion of effector T cells armed to eliminate pathogens. We have found that a specific metabolic response pathway controls T cell immunity, and will identify the signaling and physiological parameters that link the metabolic activity of T cells during their response to pathogen with their differentiation and function. )

描述（由申请人提供）：为了产生稳健和有效的免疫应答，T细胞必须整合病原体来源的和微环境信号;这些信号包括营养物和氧气的可用性。这些信号共同调节了消除病原体的效应T细胞急剧扩增所必需的代谢变化。我们已经发现，一个特定的代谢反应途径控制T细胞免疫，并将确定的信号和生理参数，连接的代谢活动的T细胞在其响应病原体与他们的分化和功能。)