HIV-associated Neuropathy: Ethnic Disparities and Pathogenesis

HIV 相关神经病:种族差异和发病机制

基本信息

项目摘要

Minorities and women now account for a disproportionate number of new HIV infections. Neuropathy is the most common neurologic complication of HIV, occurring in up to 60% of patients with advanced disease. Neuropathy is commonly painful and can have a significant negative impact on quality of life. Recent clinical trials of treatment for neuropathic pain related to HIV have had disappointing results, raising the question of whether the study medications truly lack efficacy, or if the instruments used to measure pain were poorly suited to the population under study. Pilot data suggest there may be racial and ethnic differences in clinical manifestations of HIV-associated neuropathy, including pain. The goal of this project is to better define these differences and to explore their neuro-biologic and socio-cultural underpinnings. Specific aims are: 1. To determine whether there are differences between racial and ethnic groups in clinical and neurophysiologic features of HIV-associated neuropathy 2. To determine if commonly used pain scales adequately reflect the pain experience of minority, low-literacy patients with HIV-associated distal sensory polyneuropathy (HIV-DSP) 3. To determine whether autonomic neuropathy (AN) is prevalent in HIV-positive minorities 4. To determine whether the characteristic peripheral nerve and skin biopsy pathology of HIV-DSP in the HAART-era varies with race or ethnicity Retrospective analyses will be performed on data collected by the National NeuroAIDS Tissue Consortium and the CNS HIV Antiretroviral Effects Research Study. Going forward, predominantly minority patients will be recruited for detailed neurologic assessment including: administration of pain and symptom scales; detailed neurologic assessment and quantification of deficits using validated instruments; neurophysiologic testing (nerve conduction studies, quantitative sensory testing and autonomic testing); and skin biopsy. Peripheral nerve pathology will be studied using autopsy specimens from the Manhattan HIV Brain Bank.
少数民族和妇女现在占新感染艾滋病毒人数的不成比例。神经病变是

项目成果

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Jessica Robinson-Papp其他文献

Jessica Robinson-Papp的其他文献

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{{ truncateString('Jessica Robinson-Papp', 18)}}的其他基金

Effects of Vagal Dysfunction on Gastrointestinal and Inflammatory Pathways in HIV
迷走神经功能障碍对 HIV 胃肠道和炎症通路的影响
  • 批准号:
    10819353
  • 财政年份:
    2020
  • 资助金额:
    $ 17.56万
  • 项目类别:
Effects of Vagal Dysfunction on Gastrointestinal and Inflammatory Pathways in HIV
迷走神经功能障碍对 HIV 胃肠道和炎症通路的影响
  • 批准号:
    9927114
  • 财政年份:
    2020
  • 资助金额:
    $ 17.56万
  • 项目类别:
The Icahn School of Medicine at Mount Sinai (ISMMS) EPPIC-Net Specialized Clinical Center
西奈山伊坎医学院 (ISMMS) EPPIC-Net 专业临床中心
  • 批准号:
    10208322
  • 财政年份:
    2020
  • 资助金额:
    $ 17.56万
  • 项目类别:
Effects of Vagal Dysfunction on Gastrointestinal and Inflammatory Pathways in HIV
迷走神经功能障碍对 HIV 胃肠道和炎症通路的影响
  • 批准号:
    10356148
  • 财政年份:
    2020
  • 资助金额:
    $ 17.56万
  • 项目类别:
Effects of Vagal Dysfunction on Gastrointestinal and Inflammatory Pathways in HIV
迷走神经功能障碍对 HIV 胃肠道和炎症通路的影响
  • 批准号:
    10579307
  • 财政年份:
    2020
  • 资助金额:
    $ 17.56万
  • 项目类别:
The Icahn School of Medicine at Mount Sinai (ISMMS) EPPIC-Net Specialized Clinical Center
西奈山伊坎医学院 (ISMMS) EPPIC-Net 专业临床中心
  • 批准号:
    10888777
  • 财政年份:
    2019
  • 资助金额:
    $ 17.56万
  • 项目类别:
Toward safer opioid prescribing for chronic pain in high risk populations: implementing the Centers for Disease Control Guideline (CDC) guideline in the primary care HIV clinic
为高危人群的慢性疼痛提供更安全的阿片类药物处方:在初级保健 HIV 诊所实施疾病控制中心 (CDC) 指南
  • 批准号:
    9753158
  • 财政年份:
    2017
  • 资助金额:
    $ 17.56万
  • 项目类别:
Autonomic neuropathy, gastrointestinal motility, and inflammation in HIV
HIV 的自主神经病变、胃肠道运动和炎症
  • 批准号:
    9110258
  • 财政年份:
    2015
  • 资助金额:
    $ 17.56万
  • 项目类别:
HIV-associated Neuropathy: Ethnic Disparities and Pathogenesis
HIV 相关神经病:种族差异和发病机制
  • 批准号:
    7910480
  • 财政年份:
    2009
  • 资助金额:
    $ 17.56万
  • 项目类别:
HIV-associated Neuropathy: Ethnic Disparities and Pathogenesis
HIV 相关神经病:种族差异和发病机制
  • 批准号:
    8512818
  • 财政年份:
    2009
  • 资助金额:
    $ 17.56万
  • 项目类别:

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