HIV-associated Neuropathy: Ethnic Disparities and Pathogenesis
HIV 相关神经病:种族差异和发病机制
基本信息
- 批准号:7910480
- 负责人:
- 金额:$ 17.01万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2009
- 资助国家:美国
- 起止时间:2009-08-15 至 2014-07-31
- 项目状态:已结题
- 来源:
- 关键词:AccountingAffectAnti-Retroviral AgentsAutopsyBiopsyBiopsy SpecimenBrainCharacteristicsClinicalClinical TreatmentClinical TrialsComplicationDataDistalEthnic OriginEthnic groupFDA approvedGoalsHIVHIV InfectionsHIV SeropositivityHypersensitivity skin testingKnowledgeMeasuresMinorityNational NeuroAids Tissue ConsortiumNeural ConductionNeurologicNeuropathyNeurosciencesPainPathogenesisPathologicPathologyPatientsPeripheral NervesPharmaceutical PreparationsPolyneuropathyPopulationPrevalenceQuality of lifeRaceRecruitment ActivityReportingResearchResearch PersonnelSensorySigns and SymptomsSkinSpecimenSymptomsTestingWomanadvanced diseaseautonomic neuropathyeffective therapyexperienceimmunopathologyinstrumentliteracypainful neuropathyprogramspublic health relevanceracial and ethnicracial/ethnic differenceresearch study
项目摘要
DESCRIPTION (provided by applicant): Minorities and women now account for a disproportionate number of new HIV infections. Neuropathy is the most common neurologic complication of HIV, occurring in up to 60% of patients with advanced disease. Neuropathy is commonly painful and can have a significant negative impact on quality of life. Recent clinical trials of treatment for neuropathic pain related to HIV have had disappointing results, raising the question of whether the study medications truly lack efficacy, or if the instruments used to measure pain were poorly suited to the population under study. Pilot data suggest there may be racial and ethnic differences in clinical manifestations of HIV-associated neuropathy, including pain. The goal of this project is to better define these differences and to explore their neuro-biologic and socio-cultural underpinnings. Specific aims are: 1. To determine whether there are differences between racial and ethnic groups in clinical and neurophysiologic features of HIV-associated neuropathy 2. To determine if commonly used pain scales adequately reflect the pain experience of minority, low-literacy patients with HIV-associated distal sensory polyneuropathy (HIV-DSP) 3. To determine whether autonomic neuropathy (AN) is prevalent in HIV-positive minorities 4. To determine whether the characteristic peripheral nerve and skin biopsy pathology of HIV-DSP in the HAART-era varies with race or ethnicity Retrospective analyses will be performed on data collected by the National NeuroAIDS Tissue Consortium and the CNS HIV Antiretroviral Effects Research Study. Going forward, predominantly minority patients will be recruited for detailed neurologic assessment including: administration of pain and symptom scales; detailed neurologic assessment and quantification of deficits using validated instruments; neurophysiologic testing (nerve conduction studies, quantitative sensory testing and autonomic testing); and skin biopsy. Peripheral nerve pathology will be studied using autopsy specimens from the Manhattan HIV Brain Bank.
PUBLIC HEALTH RELEVANCE: Neuropathy is a common complication of HIV which significantly reduces quality of life, and for which there is no FDA-approved treatment. HIV now disproportionately affects minorities, so if effective treatments for neuropathy are to be developed, more information is needed about its clinical and pathologic manifestations in these populations, including the reporting of pain.
描述(由申请人提供):少数民族和妇女现在占新感染艾滋病毒的人数不成比例。神经病变是HIV最常见的神经系统并发症,发生在高达60%的晚期疾病患者中。神经病变通常是痛苦的,并可能对生活质量产生显着的负面影响。最近治疗与艾滋病毒相关的神经性疼痛的临床试验结果令人失望,提出了一个问题,即研究药物是否真的缺乏疗效,或者用于测量疼痛的仪器是否不适合研究人群。初步数据表明,HIV相关神经病变(包括疼痛)的临床表现可能存在种族和民族差异。该项目的目标是更好地定义这些差异,并探索其神经生物学和社会文化基础。具体目标是:1。确定HIV相关神经病变的临床和神经生理学特征在种族和民族之间是否存在差异2。确定常用的疼痛量表是否充分反映了少数、低文化程度的HIV相关远端感觉性多发性神经病(HIV-DSP)患者的疼痛体验3。确定自主神经病变(AN)是否在HIV阳性的少数民族中普遍存在4。为了确定HAART时代HIV-DSP的特征性外周神经和皮肤活检病理学是否随人种或种族而变化,将对国家NeuroAIDS组织联盟和CNS HIV抗逆转录病毒效应研究收集的数据进行回顾性分析。今后,将招募主要是少数民族患者进行详细的神经系统评估,包括:疼痛和症状量表的管理;使用经验证的仪器进行详细的神经系统评估和缺陷量化;神经生理学测试(神经传导研究,定量感觉测试和自主神经测试);和皮肤活检。将使用来自曼哈顿HIV脑库的尸检标本研究外周神经病理学。
公共卫生相关性:神经病变是HIV的常见并发症,其显著降低生活质量,并且没有FDA批准的治疗方法。艾滋病毒现在不成比例地影响少数民族,因此,如果要开发有效的神经病治疗方法,就需要更多关于这些人群的临床和病理表现的信息,包括疼痛的报告。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Jessica Robinson-Papp其他文献
Jessica Robinson-Papp的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Jessica Robinson-Papp', 18)}}的其他基金
Effects of Vagal Dysfunction on Gastrointestinal and Inflammatory Pathways in HIV
迷走神经功能障碍对 HIV 胃肠道和炎症通路的影响
- 批准号:
9927114 - 财政年份:2020
- 资助金额:
$ 17.01万 - 项目类别:
Effects of Vagal Dysfunction on Gastrointestinal and Inflammatory Pathways in HIV
迷走神经功能障碍对 HIV 胃肠道和炎症通路的影响
- 批准号:
10819353 - 财政年份:2020
- 资助金额:
$ 17.01万 - 项目类别:
The Icahn School of Medicine at Mount Sinai (ISMMS) EPPIC-Net Specialized Clinical Center
西奈山伊坎医学院 (ISMMS) EPPIC-Net 专业临床中心
- 批准号:
10208322 - 财政年份:2020
- 资助金额:
$ 17.01万 - 项目类别:
Effects of Vagal Dysfunction on Gastrointestinal and Inflammatory Pathways in HIV
迷走神经功能障碍对 HIV 胃肠道和炎症通路的影响
- 批准号:
10356148 - 财政年份:2020
- 资助金额:
$ 17.01万 - 项目类别:
Effects of Vagal Dysfunction on Gastrointestinal and Inflammatory Pathways in HIV
迷走神经功能障碍对 HIV 胃肠道和炎症通路的影响
- 批准号:
10579307 - 财政年份:2020
- 资助金额:
$ 17.01万 - 项目类别:
The Icahn School of Medicine at Mount Sinai (ISMMS) EPPIC-Net Specialized Clinical Center
西奈山伊坎医学院 (ISMMS) EPPIC-Net 专业临床中心
- 批准号:
10888777 - 财政年份:2019
- 资助金额:
$ 17.01万 - 项目类别:
Toward safer opioid prescribing for chronic pain in high risk populations: implementing the Centers for Disease Control Guideline (CDC) guideline in the primary care HIV clinic
为高危人群的慢性疼痛提供更安全的阿片类药物处方:在初级保健 HIV 诊所实施疾病控制中心 (CDC) 指南
- 批准号:
9753158 - 财政年份:2017
- 资助金额:
$ 17.01万 - 项目类别:
Autonomic neuropathy, gastrointestinal motility, and inflammation in HIV
HIV 的自主神经病变、胃肠道运动和炎症
- 批准号:
9110258 - 财政年份:2015
- 资助金额:
$ 17.01万 - 项目类别:
HIV-associated Neuropathy: Ethnic Disparities and Pathogenesis
HIV 相关神经病:种族差异和发病机制
- 批准号:
8303342 - 财政年份:2009
- 资助金额:
$ 17.01万 - 项目类别:
HIV-associated Neuropathy: Ethnic Disparities and Pathogenesis
HIV 相关神经病:种族差异和发病机制
- 批准号:
8512818 - 财政年份:2009
- 资助金额:
$ 17.01万 - 项目类别:
相似海外基金
How Does Particle Material Properties Insoluble and Partially Soluble Affect Sensory Perception Of Fat based Products
不溶性和部分可溶的颗粒材料特性如何影响脂肪基产品的感官知觉
- 批准号:
BB/Z514391/1 - 财政年份:2024
- 资助金额:
$ 17.01万 - 项目类别:
Training Grant
BRC-BIO: Establishing Astrangia poculata as a study system to understand how multi-partner symbiotic interactions affect pathogen response in cnidarians
BRC-BIO:建立 Astrangia poculata 作为研究系统,以了解多伙伴共生相互作用如何影响刺胞动物的病原体反应
- 批准号:
2312555 - 财政年份:2024
- 资助金额:
$ 17.01万 - 项目类别:
Standard Grant
RII Track-4:NSF: From the Ground Up to the Air Above Coastal Dunes: How Groundwater and Evaporation Affect the Mechanism of Wind Erosion
RII Track-4:NSF:从地面到沿海沙丘上方的空气:地下水和蒸发如何影响风蚀机制
- 批准号:
2327346 - 财政年份:2024
- 资助金额:
$ 17.01万 - 项目类别:
Standard Grant
Graduating in Austerity: Do Welfare Cuts Affect the Career Path of University Students?
紧缩毕业:福利削减会影响大学生的职业道路吗?
- 批准号:
ES/Z502595/1 - 财政年份:2024
- 资助金额:
$ 17.01万 - 项目类别:
Fellowship
Insecure lives and the policy disconnect: How multiple insecurities affect Levelling Up and what joined-up policy can do to help
不安全的生活和政策脱节:多种不安全因素如何影响升级以及联合政策可以提供哪些帮助
- 批准号:
ES/Z000149/1 - 财政年份:2024
- 资助金额:
$ 17.01万 - 项目类别:
Research Grant
感性個人差指標 Affect-X の構築とビスポークAIサービスの基盤確立
建立个人敏感度指数 Affect-X 并为定制人工智能服务奠定基础
- 批准号:
23K24936 - 财政年份:2024
- 资助金额:
$ 17.01万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
How does metal binding affect the function of proteins targeted by a devastating pathogen of cereal crops?
金属结合如何影响谷类作物毁灭性病原体靶向的蛋白质的功能?
- 批准号:
2901648 - 财政年份:2024
- 资助金额:
$ 17.01万 - 项目类别:
Studentship
Investigating how double-negative T cells affect anti-leukemic and GvHD-inducing activities of conventional T cells
研究双阴性 T 细胞如何影响传统 T 细胞的抗白血病和 GvHD 诱导活性
- 批准号:
488039 - 财政年份:2023
- 资助金额:
$ 17.01万 - 项目类别:
Operating Grants
New Tendencies of French Film Theory: Representation, Body, Affect
法国电影理论新动向:再现、身体、情感
- 批准号:
23K00129 - 财政年份:2023
- 资助金额:
$ 17.01万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
The Protruding Void: Mystical Affect in Samuel Beckett's Prose
突出的虚空:塞缪尔·贝克特散文中的神秘影响
- 批准号:
2883985 - 财政年份:2023
- 资助金额:
$ 17.01万 - 项目类别:
Studentship