Blood and Tissue Speciman Core

血液和组织样本核心

• 批准号: 8375323
• 负责人: HARRY V. VINTERS
• 金额: $ 15.16万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-30 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8375323
• 关键词: Acute; Adult; Affect; Apolipoprotein E; Autopsy; Biochemical Markers; Biometry; Biopsy; Blood; Blood Clot; Blood Platelets; Blood Vessels; Blood coagulation; Blood flow; Blood specimen; Brain; Brain Injuries; Brain hemorrhage; Caring; Cause of Death; Cerebral Ischemia; Cerebral hemisphere hemorrhage; Cerebrovascular Disorders; Cerebrum; Chemicals; Chronic; Coagulation Process; Counterpulsation; Devices; Diagnostic; Diffusion; Disease; Embolectomy; Etiology; Evaluation; External Counterpulsation; Fellowship; Fibrinolysis; Functional disorder; Genotype; Hemorrhage; Human; Individual; Informed Consent; Infusion procedures; Innovative Therapy; International; Intervention; Ischemic Stroke; Laboratories; Light; Magnetic Resonance Imaging; Mechanics; Medical Students; Microscopic; Molecular; Molecular Analysis; Molecular Genetics; National Institute of Neurological Disorders and Stroke; Neuroendoscopy; Neuroprotective Agents; Operative Surgical Procedures; Oxygen; Pathogenesis; Patients; Pattern; Perfusion; Phase II Clinical Trials; Physicians; Plasma; Reaction; Research; Research Personnel; Research Project Grants; Research Training; Resources; Safety; Sampling; Scientist; Specimen; Stroke; Symptoms; Techniques; Technology; Telemedicine; Therapeutic; Thrombus; Tissue-Specific Gene Expression; Tissues; Training; Training Programs; Translational Research; acute stroke; aqueous; artery occlusion; career development; cerebral artery; data management; diagnostic accuracy; disability; experience; improved; minimally invasive; neuroimaging; next generation; novel; pilot trial; programs; repository; tool

Acute stroke is a common and devastating disorder, the 3rd leading cause of death and leading cause of adult disability in the US. This application for renewal of the UCLA Specialized Program of Translational Research in Acute Stroke Center proposes an integrated research/training program to develop innovative therapies for acute ischemic and hemorrhagic stroke. Five research projects are proposed. Project 1, the Therapeutic Aqueous Oxygen (TAO) Trial" is a 50 patient trial to evaluate the feasibility and safety of endovascular delivery of supersaturated, aqueous oxygen to ischemic human cerebral tissues. This trial will be the first formal study of endovascular infusion of neuroprotective agents, a highly promising complementary strategy to endovascular recanalization. Project 2, the "Intraoperative CT and Endovascular-Guided Surgery for Intracerebral Hemorrhage (ICES) Trial" is a critical phase 2 trial of a new, minimally invasive surgical technique for the evacuation of primary intracerebral hemorrhage, using mobile intra-operative CT and neuroendoscopy. In addition, studies interrogating the fundamental pathophysiology of brain injury in human ICH are proposed delineating differential gene expression, tissue morphometrics, and multimodal MR signatures in the perihematomal region. In Project 3, "Telestroke in the Field: Improving Prehospital Stroke Care with Mobile Broadband Telemedicine Technologies," will evaluate the benefit upon prehospital diagnostic accuracy and informed consent of physician-patient interaction in the field employing emerging video handset technologies. Project 4, "The MR and Recanalization of Stroke Clots Using Embolectomy (MR RESCUE) Trial," is an international, multicenter pilot trial to determine whether diffusion-perfusion MRI can identify acute cerebral ischemia patients who will benefit substantially from mechanical embolectomy with the Merci Retriever up to 8 hrs from symptom onset. Project 5, the "Counterpulsation to Upgrade Forward Flow in Stroke (CUFFS) Trial" will assess the tolerability, feasibility, and safety of increasing blood flow to ischemic cerebral fields through external counterpulsation in 30 patients with persisting arterial occlusion. Five Cores support the Projects: Administrative, Patient Access, Blood/Tissue Specimen, Biostatistics/Data Management, and Neuroimaging. A Career Development Program will train the next generation of translational scientists in neurovascular disease at the premedical, medical student, and fellowship level.

急性中风是一种常见的破坏性疾病，是美国第三大死亡原因和成人残疾的主要原因。这份申请续签加州大学洛杉矶分校急性卒中中心转化性研究专业计划的申请提出了一个综合研究/培训计划，以开发急性缺血性和出血性中风的创新疗法。提出了五个研究课题。项目1、 治疗性水氧(TAO)试验“是一项50名患者的试验，旨在评估血管内给氧的可行性和安全性。这项试验将是血管内输注神经保护剂的第一次正式研究，它是血管内再通的一种非常有前途的补充策略。项目2，术中CT和血管内引导 手术治疗脑出血(ICES)试验“是一种新的微创外科技术的关键第二阶段试验，利用术中移动式CT和神经内窥镜清除原发性脑内出血。此外，还建议对人类脑出血脑损伤的基本病理生理学进行研究，描述血肿周围区域的差异基因表达、组织形态计量学和多峰MR征象。在项目3“现场远程卒中：利用移动宽带远程医疗技术改善院前卒中护理”中，将评估采用新兴视频手持设备技术的现场医患互动对院前诊断准确性和知情同意的益处。项目4，“MR和使用栓子切除术(MR)对卒中血栓进行再通” 一项国际性的、多中心的先导性试验，旨在确定弥散-灌注磁共振成像是否能够识别急性脑缺血患者，这些患者从症状出现后8小时内使用Merci Retriver进行机械取栓术将获得显著的益处。项目5，“卒中患者的反搏以提升前向血流(CUFFS)试验”将评估增加血流量至 体外反搏治疗持续性动脉闭塞脑缺血30例 五个核心支持这些项目：管理、患者访问、血液/组织样本、生物统计/数据管理和神经成像。职业发展计划将在医学预科、医学生和研究员级别培训下一代神经血管疾病方面的转化型科学家。