NEUROPATHOLOGY CORE

ADRC的神经病理学核心（NPC）将对中心评估的个体进行尸检，以及其他同意在加州大学洛杉矶分校医学中心死亡的神经退行性疾病患者，或其尸体被转移到这里进行尸检。接受检查的患者将包括在ADRC中进行的“对照”和通过UCLA-CHS尸检服务的对照受试者；在后一组中，一份简短的电话问卷将发给家庭成员/近亲，以评估被解剖的个体在生活中是否认知正常（这是核心的一项新举措）。除了对这些患者提供适当的诊断（基于最先进的免疫组织化学研究），所有可能的尸检组织和脑脊液将被迅速冷冻、储存，供研究阿尔茨海默病和相关疾病的研究人员使用。NPC致力于为那些做优秀研究的中心提供研究材料，但这些中心缺乏具有良好特征的尸检组织/液体。这些资源也将分发给需要获得组织的当地调查人员。阿尔茨海默病患者、非阿尔茨海默病患者和对照组的尸检脑标本是为特定患者提供“金标准”诊断的重要资源，有助于评估治疗效果或不必要的并发症。随着疾病进展的生物标志物越来越多地用于监测生命中的疾病进展以及对治疗的反应，了解这些生物标志物的形态解剖学相关性（作为疾病严重程度的测量）变得至关重要。一组生物标志物，即标记脑淀粉样蛋白的新神经成像技术，需要在尸检脑标本中进行验证，而NPC为此类研究提供了有价值的材料。全国人大有一个广泛的组织分发网络，并向许多调查人员分发组织。全国人大支持加州大学洛杉矶分校的项目，合作进行国家研究（如GWAS），并鼓励国际合作研究。NPC致力于开发新方法（如组织微阵列），以促进在实验系统中发现的与神经变性相关的新分子的高通量分析和表达谱，例如使用果蝇和啮齿动物的实验系统。最后，NPC致力于通过协助制定协议、教学、会议和提供组织和神经病理学数据来支持ADRC内的其他核心和项目。

The Neuropathology Core (NPC) of the ADRC will perform autopsies on individuals evaluated in the Center, and other consented patients with neurodegenerative diseases who expire at UCLA Medical Center, or whose bodies are transferred here for that purpose. Patients examined will include 'controls' followed in the ADRC and control subjects that come through the UCLA-CHS autopsy service; in the latter group, a brief telephonic questionnaire will be administered to family members/next of kin to assess whether an autopsied individual had been cognitively normal during life (this is a new initiative of the core). In addition to providing appropriate diagnoses on these patients (based upon state-of-the-art immunohistochemical studies), tissues and CSF from all possible autopsies will be rapidly frozen, stored, and made available to investigators doing research in Alzheimer disease and related disorders. The NPC is committed to providing research materials to Centers doing excellent research, but who lack availability of well-characterized autopsy tissues/fluids. These resources also will be distributed to local investigators requiring access to tissues. Autopsy brain specimens from patients with AD, non-AD dementias and controls are an important resource to provide a 'gold standard' diagnosis in a given patient, and can assist in the evaluation of treatment efficacy or unwanted complications. As biomarkers of disease progression are increasingly used to monitor disease progression during life, as well as responses to therapy, understanding the morphoanatomic correlates of these biomarkers (as measures of disease severity) becomes crucial. One group of biomarkers, viz. new neuroimaging techniques that label brain amyloids, needs to be validated in autopsy brain specimens, and NPC is providing valuable material for such a study. The NPC has a wide tissue distribution network and disseminates tissue to many investigators. The NPC supports projects at UCLA, collaborates on national studies (e.g., GWAS), and encourages international collaborative studies. The NPC is committed to developing new methods (e.g. tissue micro-array) to facilitate high throughput analysis and expression profiles of new molecules relevant to neurodegeneration, which are discovered in experimental systems, e.g. those using Drosophila and rodents. Finally, the NPC is committed to supporting other Cores and Projects within the ADRC through assistance with developing protocols, teaching, conferences, and providing tissue and neuropathologic data.