An evaluation of a novel technology to assess neonatal jaundice

新生儿黄疸评估新技术的评价

• 批准号: 8891999
• 负责人: James A Taylor
• 金额: $ 23.86万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-04-01 至 2017-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8891999
• 关键词: Accounting; Algorithms; Bilirubin; Calibration; Caring; Cellular Phone; Characteristics; Clinical; Color; Computers; Correlation Studies; Data; Effectiveness; Electrical Engineering; Enrollment; Evaluation; Faculty; Feedback; Goals; Health Professional; Hour; Hyperbilirubinemia; Icterus; Image; Image Analysis; Infant; Kernicterus; Left; Life; Light; Lighting; Link; Measurement; Measures; Methodist Church; Methodology; Methods; Monitor; Neonatal Jaundice; Neurologic; Newborn Infant; Nurseries; Online Systems; Outpatients; Parents; Procedures; Process; Protocols documentation; Publishing; Research; Sampling; Serum; Severities; Skin; Skin Pigmentation; Specific qualifier value; System; Technology; Time; Universities; Validation; Washington; base; care systems; computer science; design; digital imaging; experience; improved; meter; multidisciplinary; neonatal care; neonate; new technology; pediatrician; prevent; public health relevance; screening; software development; technology development; tool; total measurement Bilirubin

 DESCRIPTION (provided by applicant): Neonatal jaundice, a yellowing of the skin as a result of hyperbilirubinemia, is an almost ubiquitous condition in newborn infants. In very rare circumstances, if an infant with signficant hyperbilirubinemia is undetected, kernicterus, a devastating and permanent neurologic condition, can develop. Still rare, but much more frequently, a neonate with significant jaundiced is not identified until the bilirubin level is ver high, necessitating complicated and expensive care to prevent bilirubin encephalopathy. Thus, the identification of infants with moderate hyperbilirubinemia, at levels that are easily treatable is a central focus of neonatal care in the US. Unfortunately, bilirubin levels typically peak in neonates around 96 hours of life, well after most infants are discharged from the newborn nursery. There is currently a lack of accurate, inexpensive and widely available methodologies to screen discharged infants for jaundice, leaving a notable void in the overall system of care designed to prevent severe hyperbilirubinemia. Our group of academic pediatricians and computer science and electrical engineering faculty has developed a non-invasive technology to measure bilirubin in newborn infants. The technology is based on the analysis of digital images of newborn skin that are obtained with a smartphone app that we have developed. A color calibration card is placed on the newborn's skin to control for different lighting, and other aspects of the image are standardized. The images are sent electronically to a central computer server for an analysis. The calculated bilirubin level is then downloaded to the smartphone app. In preliminary studies on a small number of infants, our technology, called the Bilicam app system, has accurately predicted bilirubin levels. The proposed study is designed to rigorously assess the ability of the Bilicam app system to accurately predict serum bilirubin levels in a racially, ethnically and geographically diverse sample of 250 newborn infants who are 3-5 days old, when bilirubin levels are peaking. The accuracy of the Bilicam app system in predicting serum bilirubin levels will be compared to published data on the accuracy of transcutaneous bilirubin meters, another non-invasive methodology for assessing newborn jaundice that is in widespread clinical use. The final goal of the project is to assess and improve the user experience with the smartphone app. A 2-year study period is planned.

 描述（由申请方提供）：新生儿黄疸，高胆红素血症导致的皮肤发黄，是新生儿中几乎普遍存在的疾病。在非常罕见的情况下，如果一个婴儿与显着的高胆红素血症是未被发现，核黄疸，一个毁灭性的和永久性的神经系统疾病，可以发展。虽然很少见，但更常见的是，新生儿严重黄疸直到胆红素水平非常高才被发现，需要复杂和昂贵的护理来预防胆红素脑病。因此，在美国新生儿护理的中心焦点是确定中度高胆红素血症的婴儿，其水平易于治疗。不幸的是，胆红素水平通常在新生儿出生后96小时左右达到峰值，大多数婴儿从新生儿托儿所出院后很久。目前缺乏准确、廉价和广泛可用的方法来筛查出院婴儿的黄疸，在旨在预防严重高胆红素血症的整个护理系统中留下了明显的空白。我们的学术儿科医生和计算机科学与电气工程学院的团队开发了一种非侵入性技术来测量新生儿的胆红素。该技术基于对新生儿皮肤数字图像的分析，这些图像是通过我们开发的智能手机应用程序获得的。颜色校准卡被放置在新生儿的皮肤上，以控制不同的照明，图像的其他方面也被标准化。图像以电子方式发送到中央计算机服务器进行分析。计算出的胆红素水平然后下载到智能手机应用程序中。在对少数婴儿的初步研究中，我们的技术，称为Bilicam应用程序系统，可以准确预测胆红素水平。拟定研究旨在严格评估Bilicam app系统准确预测胆红素水平峰值时250名3-5天大新生儿样本中血清胆红素水平的能力。将比较Bilicam app系统预测血清胆红素水平的准确性与经皮胆红素仪准确性的已发表数据，经皮胆红素仪是另一种临床广泛使用的评估新生儿黄疸的无创方法。该项目的最终目标是评估和改善智能手机应用程序的用户体验。计划进行为期2年的研究。