The Feasibility of Assessing the Prevalence of Rickets

评估佝偻病患病率的可行性

• 批准号: 7026771
• 负责人: James A Taylor
• 金额: $ 9.97万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-05-01 至 2008-10-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7026771
• 关键词: alkaline phosphatase; blood tests; breast feeding; clinical research; decision making; developmental nutrition; dietary supplements; disease /disorder prevention /control; epidemiology; health care personnel performance; health care service planning; health services research tag; health surveys; human subject; infant human (0-1 year); nutrient requirement; nutrition related tag; nutritional epidemiology; parents; patient care personnel relations; radiodiagnosis; vitamin D; vitamin D resistant rickets

DESCRIPTION (Provided by the Applicant): The Puget Sound Pediatric Research Network (PSPRN) is a practice-based research network of pediatricians in the Seattle, Washington area and at the University of Washington. The network has extensive experience in conducting large studies on contentious issues that are pertinent to children, their parents, and primary care providers. In 2004, vitamin D supplementation was recommended for all exclusively breastfed infants. This recommendation was based on sporadic reports over the last 30 years of vitamin D deficient rickets in infants and toddlers who have been exclusively breastfed. The recommendation has been controversial because it might undermine efforts to promote breasfeeding, and because the prevalence of rickets in these patients is unknown. PSPRN proposes to conduct a preliminary study to determine the feasibility of a larger planned project by the network to determine the prevalence of rickets in breastfed infants and toddlers who do not receive supplemental vitamin D. Systematic surveys will be conducted in PSPRN practices to determine current levels and trends in vitamin D supplementation. Current practices of PSPRN pediatricians regarding supplementation, and their effect of parents, will also be assessed. The utility of a serum alkaline phosphatase level as a screening test for vitamin D deficient rickets will be determined in the proposed study by obtaining levels on approximately 300 patients, 6-15 months old, seen by PSPRN practitioners, who have been breastfed. In addition to assessing possible methodologies for the larger project, the preliminary study is designed to yield standalone results with important implications.

描述（由申请人提供）：普吉特海湾儿科研究网络（PSPRN）是西雅图、华盛顿地区和华盛顿大学的儿科医生基于实践的研究网络。该网络在对与儿童、其父母和初级保健提供者有关的有争议的问题进行大型研究方面拥有丰富的经验。2004年，建议所有纯母乳喂养的婴儿补充维生素D。这一建议是基于过去30年来完全母乳喂养的婴儿和幼儿维生素D缺乏性佝偻病的零星报告。这一建议一直存在争议，因为它可能会破坏促进母乳喂养的努力，而且这些患者中佝偻病的患病率尚不清楚。PSPRN建议进行一项初步研究，以确定该网络计划的一个更大项目的可行性，以确定没有补充维生素D的母乳喂养婴儿和幼儿的佝偻病患病率。将在PSPRN实践中进行系统调查，以确定维生素D补充剂的当前水平和趋势。PSPRN儿科医生关于补充剂的现行做法及其对父母的影响也将进行评估。血清碱性磷酸酶水平作为维生素D缺乏性佝偻病的筛查试验的效用将在拟议的研究中通过获得大约300名患者的水平来确定，这些患者6-15个月大，由PSPRN从业者观察，他们已经母乳喂养。除了评估较大项目的可能方法外，初步研究旨在产生具有重要影响的独立结果。